The five-membered disulphide ring system—II: Cytostatic effects

1:2-Dithiolane derivatives have been shown to exert a cytostatic effect on strain L mouse fibroblasts in vitro. A similar effect could usually not be demonstrated on Ehrlich's ascites tumour cells in vivo, although these tumour cells were more sensitive to the antirespiratory effect of the 1:2-...

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Veröffentlicht in:	Biochemical pharmacology 1962-06, Vol.11 (6), p.453-466
1. Verfasser:	Kieler, Jørgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Disulfides Humans Old Medline Sulfides - pharmacology
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description	1:2-Dithiolane derivatives have been shown to exert a cytostatic effect on strain L mouse fibroblasts in vitro. A similar effect could usually not be demonstrated on Ehrlich's ascites tumour cells in vivo, although these tumour cells were more sensitive to the antirespiratory effect of the 1:2-dithiolane derivatives than the fibroblasts. Evidence is presented that the lack of cytostatic activity in vivo is due to rapid elimination.
doi_str_mv	10.1016/0006-2952(62)90228-9
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source	MEDLINE; Elsevier ScienceDirect Journals
subjects	Antineoplastic Agents - pharmacology Disulfides Humans Old Medline Sulfides - pharmacology
title	The five-membered disulphide ring system—II: Cytostatic effects
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