CLINICAL AND EXPERIMENTAL STUDIES ON ADENINE, VARIOUS NUCLEOSIDES AND THEIR ANALOGS IN HEMATOLOGY
In red blood cells as well as in platelets there appears to be a decrease in adenine nucleotides during storage under blood bank conditions. This can be decreased by use of anticoagulant preservatives with higher phosphate content than the standard ACD solution, through the addition of adenine and i...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 1975-08, Vol.255 (1), p.435-467 |
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| container_title | Annals of the New York Academy of Sciences |
| container_volume | 255 |
| creator | Ambrus, J. L. Ambrus, C. M. Odake, K. Mink, I. B. Shields, R. Warner, W. Bishop, C. Tritsch, G. L. Golden, G. Mittelman, A. |
| description | In red blood cells as well as in platelets there appears to be a decrease in adenine nucleotides during storage under blood bank conditions. This can be decreased by use of anticoagulant preservatives with higher phosphate content than the standard ACD solution, through the addition of adenine and inosine. Maintenance of higher ATP levels appears to be related to longer circulating life span after transfusion into patients in the case of red blood cells but not platelets. Inosine and more alkaline preservative medium also contribute to the maintenance of 2,3-DPG levels in red blood cells, and with it to the maintenance of normal hemoglobin dissociation curves and thus oxygen-carrying capacity. Certain nucleoside analogs may contribute to the preservation of platelets and of whole blood by their platelet-aggregation inhibitory activity. Platelet-aggregation inhibitors may also be useful in preventing thromboembolic episodes with potentially greater safety than anticoagulants. |
| doi_str_mv | 10.1111/j.1749-6632.1975.tb29250.x |
| format | Article |
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L. ; Ambrus, C. M. ; Odake, K. ; Mink, I. B. ; Shields, R. ; Warner, W. ; Bishop, C. ; Tritsch, G. L. ; Golden, G. ; Mittelman, A.</creator><creatorcontrib>Ambrus, J. L. ; Ambrus, C. M. ; Odake, K. ; Mink, I. B. ; Shields, R. ; Warner, W. ; Bishop, C. ; Tritsch, G. L. ; Golden, G. ; Mittelman, A.</creatorcontrib><description>In red blood cells as well as in platelets there appears to be a decrease in adenine nucleotides during storage under blood bank conditions. This can be decreased by use of anticoagulant preservatives with higher phosphate content than the standard ACD solution, through the addition of adenine and inosine. Maintenance of higher ATP levels appears to be related to longer circulating life span after transfusion into patients in the case of red blood cells but not platelets. Inosine and more alkaline preservative medium also contribute to the maintenance of 2,3-DPG levels in red blood cells, and with it to the maintenance of normal hemoglobin dissociation curves and thus oxygen-carrying capacity. Certain nucleoside analogs may contribute to the preservation of platelets and of whole blood by their platelet-aggregation inhibitory activity. Platelet-aggregation inhibitors may also be useful in preventing thromboembolic episodes with potentially greater safety than anticoagulants.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/j.1749-6632.1975.tb29250.x</identifier><identifier>PMID: 127540</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenine - blood ; Adenine - pharmacology ; Adult ; Blood Coagulation Tests ; Blood Platelets - metabolism ; Citrates ; Erythrocytes - drug effects ; Erythrocytes - metabolism ; Fibrinolysin - metabolism ; Glucose ; Humans ; Inosine - pharmacology ; Lactates - blood ; Male ; Nucleosides - blood ; Ouabain - pharmacology ; Oxygen - blood ; Phosphates ; Potassium - blood ; Ribonucleotides - biosynthesis ; Structure-Activity Relationship ; Time Factors ; Uridine - pharmacology</subject><ispartof>Annals of the New York Academy of Sciences, 1975-08, Vol.255 (1), p.435-467</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4075-46fe84bbd45c5214bdbce2cbbf29a76cf354226d4a4cb0d5d7047d08d021cb6b3</citedby><cites>FETCH-LOGICAL-c4075-46fe84bbd45c5214bdbce2cbbf29a76cf354226d4a4cb0d5d7047d08d021cb6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1749-6632.1975.tb29250.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1749-6632.1975.tb29250.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/127540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ambrus, J. L.</creatorcontrib><creatorcontrib>Ambrus, C. M.</creatorcontrib><creatorcontrib>Odake, K.</creatorcontrib><creatorcontrib>Mink, I. B.</creatorcontrib><creatorcontrib>Shields, R.</creatorcontrib><creatorcontrib>Warner, W.</creatorcontrib><creatorcontrib>Bishop, C.</creatorcontrib><creatorcontrib>Tritsch, G. L.</creatorcontrib><creatorcontrib>Golden, G.</creatorcontrib><creatorcontrib>Mittelman, A.</creatorcontrib><title>CLINICAL AND EXPERIMENTAL STUDIES ON ADENINE, VARIOUS NUCLEOSIDES AND THEIR ANALOGS IN HEMATOLOGY</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>In red blood cells as well as in platelets there appears to be a decrease in adenine nucleotides during storage under blood bank conditions. This can be decreased by use of anticoagulant preservatives with higher phosphate content than the standard ACD solution, through the addition of adenine and inosine. Maintenance of higher ATP levels appears to be related to longer circulating life span after transfusion into patients in the case of red blood cells but not platelets. Inosine and more alkaline preservative medium also contribute to the maintenance of 2,3-DPG levels in red blood cells, and with it to the maintenance of normal hemoglobin dissociation curves and thus oxygen-carrying capacity. Certain nucleoside analogs may contribute to the preservation of platelets and of whole blood by their platelet-aggregation inhibitory activity. Platelet-aggregation inhibitors may also be useful in preventing thromboembolic episodes with potentially greater safety than anticoagulants.</description><subject>Adenine - blood</subject><subject>Adenine - pharmacology</subject><subject>Adult</subject><subject>Blood Coagulation Tests</subject><subject>Blood Platelets - metabolism</subject><subject>Citrates</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - metabolism</subject><subject>Fibrinolysin - metabolism</subject><subject>Glucose</subject><subject>Humans</subject><subject>Inosine - pharmacology</subject><subject>Lactates - blood</subject><subject>Male</subject><subject>Nucleosides - blood</subject><subject>Ouabain - pharmacology</subject><subject>Oxygen - blood</subject><subject>Phosphates</subject><subject>Potassium - blood</subject><subject>Ribonucleotides - biosynthesis</subject><subject>Structure-Activity Relationship</subject><subject>Time Factors</subject><subject>Uridine - pharmacology</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMFP2zAUxq2JAR3sP-AQ7cBpyWzHjpNdUNQa6qk4qEk32MWKHUdqaSmLW63893PWCs68i9_z977vST8AviAYIV_fFhFiJAuTJMYRyhiNNhpnmMJo9wEMXqUjMICQsTDNcHwKPjm3gBDhlLATcIwwowQOQD2cCCmG-STI5Sjg93d8Km65rPxHWc1GgpdBIYN8xKWQ_GvwM5-KYlYGcjac8KIUI6_3xmrMxdR3-aS4KQMhgzG_zavCTw_n4GNbL539fHjPwOyaV8Nx6MX-cGgIZDQkSWtTonVDqKEYEd1oY7HRusVZzRLTxpRgnDSkJkbDhjYMEtbAtIEYGZ3o-Axc7nOfu_WfrXUbtZo7Y5fL-smut06lMUwoQ5lf_L5fNN3auc626rmbr-ruRSGoerxqoXqGqmeoerzqgFftvPnicGWrV7Z5s_7n6eWrvfx3vrQv7whW8iEvSUx9QrhPmLuN3b0m1N2jSljsLb_kjYLwh_x9dy3VffwPZA-RvA</recordid><startdate>197508</startdate><enddate>197508</enddate><creator>Ambrus, J. L.</creator><creator>Ambrus, C. M.</creator><creator>Odake, K.</creator><creator>Mink, I. B.</creator><creator>Shields, R.</creator><creator>Warner, W.</creator><creator>Bishop, C.</creator><creator>Tritsch, G. L.</creator><creator>Golden, G.</creator><creator>Mittelman, A.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197508</creationdate><title>CLINICAL AND EXPERIMENTAL STUDIES ON ADENINE, VARIOUS NUCLEOSIDES AND THEIR ANALOGS IN HEMATOLOGY</title><author>Ambrus, J. L. ; Ambrus, C. M. ; Odake, K. ; Mink, I. B. ; Shields, R. ; Warner, W. ; Bishop, C. ; Tritsch, G. 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| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 1975-08, Vol.255 (1), p.435-467 |
| issn | 0077-8923 1749-6632 |
| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Adenine - blood Adenine - pharmacology Adult Blood Coagulation Tests Blood Platelets - metabolism Citrates Erythrocytes - drug effects Erythrocytes - metabolism Fibrinolysin - metabolism Glucose Humans Inosine - pharmacology Lactates - blood Male Nucleosides - blood Ouabain - pharmacology Oxygen - blood Phosphates Potassium - blood Ribonucleotides - biosynthesis Structure-Activity Relationship Time Factors Uridine - pharmacology |
| title | CLINICAL AND EXPERIMENTAL STUDIES ON ADENINE, VARIOUS NUCLEOSIDES AND THEIR ANALOGS IN HEMATOLOGY |
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