Immunofluorescent Studies of Ocular Cicatricial Pemphigoid
Using direct and indirect immunofluorescent techniques, we studied ten patients with cicatricial pemphigoid (chronic cicatricial conjunctivitis). Serologic and histologic evaluation of 13 conjunctival, 12 mucous membrane, and 11 skin specimens from the ten patients showed that three had immunoglobul...
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| Veröffentlicht in: | American journal of ophthalmology 1975-11, Vol.80 (5), p.825-831 |
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| container_end_page | 831 |
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| container_issue | 5 |
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| container_title | American journal of ophthalmology |
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| creator | Furey, Nancy West, Carole Andrews, Thomas Paul, Promila Daman Bean, Samuel F. |
| description | Using direct and indirect immunofluorescent techniques, we studied ten patients with cicatricial pemphigoid (chronic cicatricial conjunctivitis). Serologic and histologic evaluation of 13 conjunctival, 12 mucous membrane, and 11 skin specimens from the ten patients showed that three had immunoglobulin deposition at the basement membrane zone of the conjunctiva. One patient had immunoglobulin deposited in the affected skin and oral mucosa. Two patients had circulating basement membrane zone antibodies that bound to their own tissue but not to guinea pig lip or human skin. |
| doi_str_mv | 10.1016/0002-9394(75)90278-0 |
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Serologic and histologic evaluation of 13 conjunctival, 12 mucous membrane, and 11 skin specimens from the ten patients showed that three had immunoglobulin deposition at the basement membrane zone of the conjunctiva. One patient had immunoglobulin deposited in the affected skin and oral mucosa. 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Serologic and histologic evaluation of 13 conjunctival, 12 mucous membrane, and 11 skin specimens from the ten patients showed that three had immunoglobulin deposition at the basement membrane zone of the conjunctiva. One patient had immunoglobulin deposited in the affected skin and oral mucosa. Two patients had circulating basement membrane zone antibodies that bound to their own tissue but not to guinea pig lip or human skin.</description><subject>Adult</subject><subject>Aged</subject><subject>Conjunctiva - immunology</subject><subject>Conjunctivitis - immunology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Mucosa - immunology</subject><subject>Skin - immunology</subject><subject>Skin Diseases, Vesiculobullous - immunology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4zj6DxS6El1Ub5q2aVwIMvgYGBhBXYc0vdFIOxmTVvDf29pBd64Ol3Pu6yPkmMIFBZpfAkASCybSM56dC0h4EcMOmdKCi5gWgu6S6W9knxyE8N6XOU_5hEwoBZYnfEquFk3TrZ2pO-cxaFy30VPbVRZD5Ey00l2tfDS3WrXeaqvq6BGbzZt9dbY6JHtG1QGPtjojL3e3z_OHeLm6X8xvlrFmGW9jnYmM00QA55AznZe0LJM058iUKQG1VgVVvQKtSkEzLpTJgEFRlAnTxhg2I6fj3I13Hx2GVja2v7Su1RpdF2TBIKdJAX0wHYPauxA8GrnxtlH-S1KQAzI58JADD8kz-YNMDm0n2_ld2WD11zQy6v3r0cf-yU-LXgZtca2xsh51Kytn_1_wDbiDekw</recordid><startdate>197511</startdate><enddate>197511</enddate><creator>Furey, Nancy</creator><creator>West, Carole</creator><creator>Andrews, Thomas</creator><creator>Paul, Promila Daman</creator><creator>Bean, Samuel F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197511</creationdate><title>Immunofluorescent Studies of Ocular Cicatricial Pemphigoid</title><author>Furey, Nancy ; West, Carole ; Andrews, Thomas ; Paul, Promila Daman ; Bean, Samuel F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-c5957129077063c6b1bb2467e3afb0ecca81a0ec01db91579af503088b23cfff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Conjunctiva - immunology</topic><topic>Conjunctivitis - immunology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Mucosa - immunology</topic><topic>Skin - immunology</topic><topic>Skin Diseases, Vesiculobullous - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furey, Nancy</creatorcontrib><creatorcontrib>West, Carole</creatorcontrib><creatorcontrib>Andrews, Thomas</creatorcontrib><creatorcontrib>Paul, Promila Daman</creatorcontrib><creatorcontrib>Bean, Samuel F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furey, Nancy</au><au>West, Carole</au><au>Andrews, Thomas</au><au>Paul, Promila Daman</au><au>Bean, Samuel F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunofluorescent Studies of Ocular Cicatricial Pemphigoid</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1975-11</date><risdate>1975</risdate><volume>80</volume><issue>5</issue><spage>825</spage><epage>831</epage><pages>825-831</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><abstract>Using direct and indirect immunofluorescent techniques, we studied ten patients with cicatricial pemphigoid (chronic cicatricial conjunctivitis). Serologic and histologic evaluation of 13 conjunctival, 12 mucous membrane, and 11 skin specimens from the ten patients showed that three had immunoglobulin deposition at the basement membrane zone of the conjunctiva. One patient had immunoglobulin deposited in the affected skin and oral mucosa. Two patients had circulating basement membrane zone antibodies that bound to their own tissue but not to guinea pig lip or human skin.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1103627</pmid><doi>10.1016/0002-9394(75)90278-0</doi><tpages>7</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 1975-11, Vol.80 (5), p.825-831 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Conjunctiva - immunology Conjunctivitis - immunology Female Fluorescent Antibody Technique Humans Male Middle Aged Mouth Mucosa - immunology Skin - immunology Skin Diseases, Vesiculobullous - immunology |
| title | Immunofluorescent Studies of Ocular Cicatricial Pemphigoid |
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