Effect of methylxanthines on hepatic microsomal enzymes in the rat

Outbred Charles River CD male rats were given one of three methylxanthines (caffeine, theophylline, or theobromine) separately or in combination. Pretreatment with these substances lasted either 3 days, when rats were given high doses of methylxanthines (150 mg/kg/day), or 6 days when the lower dose...

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Veröffentlicht in:	Toxicology and applied pharmacology 1975-01, Vol.33 (3), p.575-581
Hauptverfasser:	Aeschbacher, Hans-Ulrich, Würzner, Hans-Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyrine N-Demethylase - metabolism Aniline Hydroxylase - metabolism Animals caffeine Caffeine - pharmacology Male Microsomes, Liver - drug effects Microsomes, Liver - enzymology Nitroanisole O-Demethylase - metabolism Proteins - metabolism Rats theobromine Theobromine - pharmacology theophylline Theophylline - pharmacology Time Factors
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