Failure of Transient Progesterone Deprivation to Induce Ova Implantation in Ovariectomized Rats.
Summary Daily injections of 4 mg progesterone caused a delay in implantation of ova in 50 rats ovariectomized on the third day of pregnancy. The day sperm were found in the vaginal smear was designated day 1 of pregnancy. This response was not altered by temporary withdrawal of progesterone on day 9...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1962-11, Vol.111 (2), p.372-375 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 111 |
| creator | Nutting, Ehard F. Meyer, Roland K. |
| description | Summary
Daily injections of 4 mg progesterone caused a delay in implantation of ova in 50 rats ovariectomized on the third day of pregnancy. The day sperm were found in the vaginal smear was designated day 1 of pregnancy. This response was not altered by temporary withdrawal of progesterone on day 9, 9 and 10, or 13 of pregnancy. Nidation was subsequently induced in the same animals shortly after beginning daily injections of 1 μg estrone in combination with 4 mg progesterone. The number of rats with implantation sites and total number of sites in the experimental groups was not significantly different from corresponding control values. At autopsy 16 days after beginning estrone-progesterone treatment, embryo survival was significantly lower only when progesterone was deprived on day 9 of pregnancy. |
| doi_str_mv | 10.3181/00379727-111-27795 |
| format | Article |
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Daily injections of 4 mg progesterone caused a delay in implantation of ova in 50 rats ovariectomized on the third day of pregnancy. The day sperm were found in the vaginal smear was designated day 1 of pregnancy. This response was not altered by temporary withdrawal of progesterone on day 9, 9 and 10, or 13 of pregnancy. Nidation was subsequently induced in the same animals shortly after beginning daily injections of 1 μg estrone in combination with 4 mg progesterone. The number of rats with implantation sites and total number of sites in the experimental groups was not significantly different from corresponding control values. At autopsy 16 days after beginning estrone-progesterone treatment, embryo survival was significantly lower only when progesterone was deprived on day 9 of pregnancy.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-111-27795</identifier><identifier>PMID: 13939277</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Castration ; Embryo Implantation ; Old Medline ; Ovum ; Progesterone ; Rats</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1962-11, Vol.111 (2), p.372-375</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-e0738082bb7aca8028381c0bfa6517bb1ef414301b7b634c9dfb1b23677f15cf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13939277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nutting, Ehard F.</creatorcontrib><creatorcontrib>Meyer, Roland K.</creatorcontrib><title>Failure of Transient Progesterone Deprivation to Induce Ova Implantation in Ovariectomized Rats.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Daily injections of 4 mg progesterone caused a delay in implantation of ova in 50 rats ovariectomized on the third day of pregnancy. The day sperm were found in the vaginal smear was designated day 1 of pregnancy. This response was not altered by temporary withdrawal of progesterone on day 9, 9 and 10, or 13 of pregnancy. Nidation was subsequently induced in the same animals shortly after beginning daily injections of 1 μg estrone in combination with 4 mg progesterone. The number of rats with implantation sites and total number of sites in the experimental groups was not significantly different from corresponding control values. At autopsy 16 days after beginning estrone-progesterone treatment, embryo survival was significantly lower only when progesterone was deprived on day 9 of pregnancy.</description><subject>Animals</subject><subject>Castration</subject><subject>Embryo Implantation</subject><subject>Old Medline</subject><subject>Ovum</subject><subject>Progesterone</subject><subject>Rats</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLwzAYhoMobk7_gAfJyVtnvqZt2qNMp4PBROY5JunX0bE2M2kH-uvN3MSbp0DyvG--7yHkGtiYQw53jHFRiFhEABDFQhTpCRlCytOIZ0VxSoZ7INoTA3Lh_ZoxSEWcnZMB8IIXITEk71NVb3qH1FZ06VTra2w7-uLsCn2HzrZIH3Dr6p3qatvSztJZW_YG6WKn6KzZblTbHZ7qdn_najSdbeovLOmr6vz4kpxVauPx6niOyNv0cTl5juaLp9nkfh4ZnkAXIRM8Z3mstVBG5SzOeQ6G6UplKQitAasEEs5AC53xxBRlpUHHPBOigtRUfERuD71bZz_6MLxsam9wEwZE23uZ8yAjfBLA-AAaZ713WMmwXqPcpwQm917lr1cZvMofryF0c2zvdYPlX-QoMgB3B8CrFcq17V0btv2v8htGp4Fv</recordid><startdate>196211</startdate><enddate>196211</enddate><creator>Nutting, Ehard F.</creator><creator>Meyer, Roland K.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196211</creationdate><title>Failure of Transient Progesterone Deprivation to Induce Ova Implantation in Ovariectomized Rats.</title><author>Nutting, Ehard F. ; Meyer, Roland K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-e0738082bb7aca8028381c0bfa6517bb1ef414301b7b634c9dfb1b23677f15cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>Animals</topic><topic>Castration</topic><topic>Embryo Implantation</topic><topic>Old Medline</topic><topic>Ovum</topic><topic>Progesterone</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nutting, Ehard F.</creatorcontrib><creatorcontrib>Meyer, Roland K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nutting, Ehard F.</au><au>Meyer, Roland K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Failure of Transient Progesterone Deprivation to Induce Ova Implantation in Ovariectomized Rats.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1962-11</date><risdate>1962</risdate><volume>111</volume><issue>2</issue><spage>372</spage><epage>375</epage><pages>372-375</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Daily injections of 4 mg progesterone caused a delay in implantation of ova in 50 rats ovariectomized on the third day of pregnancy. The day sperm were found in the vaginal smear was designated day 1 of pregnancy. This response was not altered by temporary withdrawal of progesterone on day 9, 9 and 10, or 13 of pregnancy. Nidation was subsequently induced in the same animals shortly after beginning daily injections of 1 μg estrone in combination with 4 mg progesterone. The number of rats with implantation sites and total number of sites in the experimental groups was not significantly different from corresponding control values. At autopsy 16 days after beginning estrone-progesterone treatment, embryo survival was significantly lower only when progesterone was deprived on day 9 of pregnancy.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13939277</pmid><doi>10.3181/00379727-111-27795</doi><tpages>4</tpages></addata></record> |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 1962-11, Vol.111 (2), p.372-375 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83037073 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Castration Embryo Implantation Old Medline Ovum Progesterone Rats |
| title | Failure of Transient Progesterone Deprivation to Induce Ova Implantation in Ovariectomized Rats. |
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