A test tube reaction for the determination of the absolute configuration of α-amino acids

A test tube reaction for the determination of the absolute configuration of α-amino acids

2-Methoxy-2,4-diphenyl-3(2 H)-furanone (MDPF) reacts readily with α-amino acids to form pyrrolinone-type chromophores with long wavelength absorption maxima at 370–390 nm. Measurement of the chiroptical properties of such reaction mixtures, without isolation of products, enables one to determine the...

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Veröffentlicht in:Biochemical and biophysical research communications 1975-09, Vol.66 (1), p.75-80
Hauptverfasser: Toome, V., Reymond, G.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids
Circular Dichroism
Indicators and Reagents
Methods
Molecular Conformation
Spectrophotometry, Ultraviolet
Stereoisomerism
Structure-Activity Relationship
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Zusammenfassung:2-Methoxy-2,4-diphenyl-3(2 H)-furanone (MDPF) reacts readily with α-amino acids to form pyrrolinone-type chromophores with long wavelength absorption maxima at 370–390 nm. Measurement of the chiroptical properties of such reaction mixtures, without isolation of products, enables one to determine the absolute configuration of α-amino acids in situ.
ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(75)80296-8