The Effect of Reticulocytosis in the Rabbit on the Activities of Enzymes in Pyrimidine Biosynthesis
Five sequential enzymes leading to the formation of uridine-5'-phosphate were studied in acetophenylhydrazine-induced reticulocytes in the rabbit. All of these enzymes—aspartate carbamyltransferase, dihydroorotase, dihydroorotic dehydrogenase, orotidylic pyrophosphorylase, and orotidylic decarb...
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| Veröffentlicht in: | Blood 1962-05, Vol.19 (5), p.593-600 |
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| creator | Lotz, Myron Smith, Lloyd H. |
| description | Five sequential enzymes leading to the formation of uridine-5'-phosphate were studied in acetophenylhydrazine-induced reticulocytes in the rabbit. All of these enzymes—aspartate carbamyltransferase, dihydroorotase, dihydroorotic dehydrogenase, orotidylic pyrophosphorylase, and orotidylic decarboxylase—decreased markedly in activity during in vivo maturation and aging of the reticulocytes. In analogy to previous studies on purine nucleotide biosynthesis, it is concluded that the reticulocyte, but not the mature erythrocyte, is capable of de novo pyrimidine nucleotide biosynthesis. |
| doi_str_mv | 10.1182/blood.V19.5.593.593 |
| format | Article |
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In analogy to previous studies on purine nucleotide biosynthesis, it is concluded that the reticulocyte, but not the mature erythrocyte, is capable of de novo pyrimidine nucleotide biosynthesis.</description><subject>Animals</subject><subject>Enzymes - blood</subject><subject>Erythrocytes - metabolism</subject><subject>Nucleosides - metabolism</subject><subject>Nucleotides - metabolism</subject><subject>Old Medline</subject><subject>Pyrimidines - metabolism</subject><subject>Rabbits</subject><subject>Reticulocytosis</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LwzAYh4Mobk4_gSA9eWtNmqZtDh7mmH9goIzpNaTJW4x0zWzaQf30puvAm4eXEHh-v7x5ELomOCIkj--KylodfRAesYhxOswJmhIW5yHGMT5FU4xxGiY8IxN04dwXxiShMTtHE5IkaZpjPEVq8wnBsixBtYEtgzW0RnWVVX1rnXGBqYPWA2tZFMYD422uWrM3rQE3RJb1T7-FA_rWN2ZrtKkheDDW9bWnfcslOitl5eDqeM7Q--Nys3gOV69PL4v5KlQJjtuQyDxRlEOmCCtpTHLGeZ5pLHnGKdFJCimVSZH7SWkqKdeacUxjrbKiYFzSGbode3eN_e7AtWJrnIKqkjXYzomceiEZxR6kI6ga61wDpdj5xWXTC4LF4FYc3ArvVjDhvQ7jUzfH-q7Ygv7LHGV64H4EwH9yb6ARThmoFWjTeL9CW_PvA78TUYu2</recordid><startdate>196205</startdate><enddate>196205</enddate><creator>Lotz, Myron</creator><creator>Smith, Lloyd H.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196205</creationdate><title>The Effect of Reticulocytosis in the Rabbit on the Activities of Enzymes in Pyrimidine Biosynthesis</title><author>Lotz, Myron ; Smith, Lloyd H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-1a84c39e7c15f321859987d0a97931d46e63a4b8a4b636a39dd59032dc7bb59a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>Animals</topic><topic>Enzymes - blood</topic><topic>Erythrocytes - metabolism</topic><topic>Nucleosides - metabolism</topic><topic>Nucleotides - metabolism</topic><topic>Old Medline</topic><topic>Pyrimidines - metabolism</topic><topic>Rabbits</topic><topic>Reticulocytosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lotz, Myron</creatorcontrib><creatorcontrib>Smith, Lloyd H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lotz, Myron</au><au>Smith, Lloyd H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Reticulocytosis in the Rabbit on the Activities of Enzymes in Pyrimidine Biosynthesis</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1962-05</date><risdate>1962</risdate><volume>19</volume><issue>5</issue><spage>593</spage><epage>600</epage><pages>593-600</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Five sequential enzymes leading to the formation of uridine-5'-phosphate were studied in acetophenylhydrazine-induced reticulocytes in the rabbit. 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| ispartof | Blood, 1962-05, Vol.19 (5), p.593-600 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Animals Enzymes - blood Erythrocytes - metabolism Nucleosides - metabolism Nucleotides - metabolism Old Medline Pyrimidines - metabolism Rabbits Reticulocytosis |
| title | The Effect of Reticulocytosis in the Rabbit on the Activities of Enzymes in Pyrimidine Biosynthesis |
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