Antiarrhythmics. N-(Aminoalkylene)trifluoroethoxybenzamides and N-(aminoalkylene)trifluoroethoxynaphthamides
Benzamides and naphthamides characterized by one or more 2,2,2-trifluoroethoxy ring substituents have been prepared and evaluated as antiarrhythmic agents in mice. Structure-action studies reveal that antiarrhythmic activity is highly dependent upon the number and position of 2,2,2-trifluoroethoxy g...
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| Veröffentlicht in: | Journal of medicinal chemistry 1975-11, Vol.18 (11), p.1130-1134 |
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| container_end_page | 1134 |
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| container_issue | 11 |
| container_start_page | 1130 |
| container_title | Journal of medicinal chemistry |
| container_volume | 18 |
| creator | Banitt, E. H Coyne, W. E Schmid, J. R Mendel, A |
| description | Benzamides and naphthamides characterized by one or more 2,2,2-trifluoroethoxy ring substituents have been prepared and evaluated as antiarrhythmic agents in mice. Structure-action studies reveal that antiarrhythmic activity is highly dependent upon the number and position of 2,2,2-trifluoroethoxy groups. The most potent compounds are derived from 2,5-bis(2,2,2-trifluoroethoxy)benzamide, and, within this group, wide variation of the amide side chain is possible without adversely affecting the antiarrhythmic activity. |
| doi_str_mv | 10.1021/jm00245a017 |
| format | Article |
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The most potent compounds are derived from 2,5-bis(2,2,2-trifluoroethoxy)benzamide, and, within this group, wide variation of the amide side chain is possible without adversely affecting the antiarrhythmic activity.</description><identifier>ISSN: 0022-2623</identifier><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm00245a017</identifier><identifier>PMID: 1177259</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Anti-Arrhythmia Agents - chemical synthesis ; Anti-Arrhythmia Agents - therapeutic use ; Benzamides - chemical synthesis ; Benzamides - therapeutic use ; Mice ; Naphthalenes - chemical synthesis ; Naphthalenes - therapeutic use ; Structure-Activity Relationship ; Ventricular Fibrillation - prevention & control</subject><ispartof>Journal of medicinal chemistry, 1975-11, Vol.18 (11), p.1130-1134</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a354t-8d99e4ece2816f8802dae4deecb1cfff63ef4221d9501b6718d4e2fc87e294893</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm00245a017$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm00245a017$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1177259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banitt, E. 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The most potent compounds are derived from 2,5-bis(2,2,2-trifluoroethoxy)benzamide, and, within this group, wide variation of the amide side chain is possible without adversely affecting the antiarrhythmic activity.</description><subject>Animals</subject><subject>Anti-Arrhythmia Agents - chemical synthesis</subject><subject>Anti-Arrhythmia Agents - therapeutic use</subject><subject>Benzamides - chemical synthesis</subject><subject>Benzamides - therapeutic use</subject><subject>Mice</subject><subject>Naphthalenes - chemical synthesis</subject><subject>Naphthalenes - therapeutic use</subject><subject>Structure-Activity Relationship</subject><subject>Ventricular Fibrillation - prevention & control</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoc06vvBZ25QfSmaRpk1yOqVOZH7h5HbL2hHb2YyYtbP56OzrUC_HqwHmf8x54EDomeEAwJVeLHGPKAo0J30FdElDsMYHZLuo2e-rRkPr76MC5BcbYJ9TvoA4hnNNAdlE2LKpUW5usqyRPIzfoP3nnwzwtSp29rzMo4KKyqcnq0pZQJeVqPYfiU-dpDK6vi3iD6__wQi-TKmkPDtGe0ZmDo-3sobfbm9nozps8j-9Hw4mn_YBVnoilBAYRUEFCIwSmsQYWA0RzEhljQh8Mo5TEMsBkHnIiYgbURIIDlUxIv4dO296lLT9qcJXKUxdBlukCytopQaWU3A8b8LIFI1s6Z8GopU1zbdeKYLVxq365beiTbW09zyH-YVuZTe61eeoqWH3H2r6rkPs8ULOXqXp4fB1fkylXk4Y_a3kdObUoa1s0Uv78_AUIBZOJ</recordid><startdate>19751101</startdate><enddate>19751101</enddate><creator>Banitt, E. 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R ; Mendel, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a354t-8d99e4ece2816f8802dae4deecb1cfff63ef4221d9501b6718d4e2fc87e294893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Anti-Arrhythmia Agents - chemical synthesis</topic><topic>Anti-Arrhythmia Agents - therapeutic use</topic><topic>Benzamides - chemical synthesis</topic><topic>Benzamides - therapeutic use</topic><topic>Mice</topic><topic>Naphthalenes - chemical synthesis</topic><topic>Naphthalenes - therapeutic use</topic><topic>Structure-Activity Relationship</topic><topic>Ventricular Fibrillation - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banitt, E. H</creatorcontrib><creatorcontrib>Coyne, W. E</creatorcontrib><creatorcontrib>Schmid, J. R</creatorcontrib><creatorcontrib>Mendel, A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banitt, E. H</au><au>Coyne, W. E</au><au>Schmid, J. R</au><au>Mendel, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiarrhythmics. N-(Aminoalkylene)trifluoroethoxybenzamides and N-(aminoalkylene)trifluoroethoxynaphthamides</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J. Med. Chem</addtitle><date>1975-11-01</date><risdate>1975</risdate><volume>18</volume><issue>11</issue><spage>1130</spage><epage>1134</epage><pages>1130-1134</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><abstract>Benzamides and naphthamides characterized by one or more 2,2,2-trifluoroethoxy ring substituents have been prepared and evaluated as antiarrhythmic agents in mice. Structure-action studies reveal that antiarrhythmic activity is highly dependent upon the number and position of 2,2,2-trifluoroethoxy groups. The most potent compounds are derived from 2,5-bis(2,2,2-trifluoroethoxy)benzamide, and, within this group, wide variation of the amide side chain is possible without adversely affecting the antiarrhythmic activity.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>1177259</pmid><doi>10.1021/jm00245a017</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1975-11, Vol.18 (11), p.1130-1134 |
| issn | 0022-2623 1520-4804 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Anti-Arrhythmia Agents - chemical synthesis Anti-Arrhythmia Agents - therapeutic use Benzamides - chemical synthesis Benzamides - therapeutic use Mice Naphthalenes - chemical synthesis Naphthalenes - therapeutic use Structure-Activity Relationship Ventricular Fibrillation - prevention & control |
| title | Antiarrhythmics. N-(Aminoalkylene)trifluoroethoxybenzamides and N-(aminoalkylene)trifluoroethoxynaphthamides |
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