Human intestinal specificity toward dietary sterols studied by balance methods
Human intestinal specificity toward sterols was studied by a balance method in 10 hyperlipoproteinemic patients fed plant sterol mixture with chromium sesquioxide as fecal flow marker. The mean fecal recovery of campesterol (C₂₈) was 20% less than that of β-sitosterol (C₂₂). This difference persiste...
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| Veröffentlicht in: | Nutrition and metabolism (Basel) 1975, Vol.18 (1), p.23-30 |
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| container_title | Nutrition and metabolism (Basel) |
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| creator | Subbiah, M.T.R Kottke, B.A Carlo, I.A Naylor, M.C |
| description | Human intestinal specificity toward sterols was studied by a balance method in 10 hyperlipoproteinemic patients fed plant sterol mixture with chromium sesquioxide as fecal flow marker. The mean fecal recovery of campesterol (C₂₈) was 20% less than that of β-sitosterol (C₂₂). This difference persisted when corrected for fecal flow (by marker recovery), indicating differences in their intestinal uptake (C₂₈ > C₂₂). The ratio of fecal cholesterol to its 5β-reduction products was lower than that of β-sitosterol in all patients; in vitro, 5β-reduction of both sterols was similar. The recovery of sterols from patients was unrelated to their 5β-reduction in the intestine. |
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The mean fecal recovery of campesterol (C₂₈) was 20% less than that of β-sitosterol (C₂₂). This difference persisted when corrected for fecal flow (by marker recovery), indicating differences in their intestinal uptake (C₂₈ > C₂₂). The ratio of fecal cholesterol to its 5β-reduction products was lower than that of β-sitosterol in all patients; in vitro, 5β-reduction of both sterols was similar. The recovery of sterols from patients was unrelated to their 5β-reduction in the intestine.</description><identifier>ISSN: 0029-6678</identifier><identifier>EISSN: 2571-6506</identifier><identifier>PMID: 1165855</identifier><language>eng</language><publisher>Switzerland: S. 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The mean fecal recovery of campesterol (C₂₈) was 20% less than that of β-sitosterol (C₂₂). This difference persisted when corrected for fecal flow (by marker recovery), indicating differences in their intestinal uptake (C₂₈ > C₂₂). The ratio of fecal cholesterol to its 5β-reduction products was lower than that of β-sitosterol in all patients; in vitro, 5β-reduction of both sterols was similar. The recovery of sterols from patients was unrelated to their 5β-reduction in the intestine.</description><subject>Cholesterol - analogs & derivatives</subject><subject>Cholesterol, Dietary - metabolism</subject><subject>Chromium - analysis</subject><subject>Feces - chemistry</subject><subject>human nutrition</subject><subject>Humans</subject><subject>Hyperlipidemias - metabolism</subject><subject>Intestines - metabolism</subject><subject>nutrition education</subject><subject>Original Papers</subject><subject>Phytosterols - metabolism</subject><subject>Sitosterols - metabolism</subject><issn>0029-6678</issn><issn>2571-6506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEUhYMotdT-BDErdwNJZvJaSlFbKLrQroc87mjKPOokg_TfG2nRuzlwv8PlnHuB5oxLWghOxCWaE8J0IYRU12gZ457kyYQxMUMzSgVXnM_Ry3rqTI9DnyCm0JsWxwO40AQX0hGn4duMHvsAyYxHHBOMQxuzTnnlsT1ia1rTO8AdpM_Bxxt01Zg2wvKsC7R7enxfrYvt6_Nm9bAtGqqqVFjrKumFdq4C0CCFVdQZb4mQjGhNtaookMZWXEgHgkpqPW2AlL6sFPW-XKD7093DOHxNOXrdheigzWFgmGKtmNa6FGU23p6Nk-3A14cxdLlKfX7AP9_HNIx_uOJEKU5--d2JN2aozccYYr17Y4SWhEmhJOPlD_ntbKM</recordid><startdate>1975</startdate><enddate>1975</enddate><creator>Subbiah, M.T.R</creator><creator>Kottke, B.A</creator><creator>Carlo, I.A</creator><creator>Naylor, M.C</creator><general>S. 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The mean fecal recovery of campesterol (C₂₈) was 20% less than that of β-sitosterol (C₂₂). This difference persisted when corrected for fecal flow (by marker recovery), indicating differences in their intestinal uptake (C₂₈ > C₂₂). The ratio of fecal cholesterol to its 5β-reduction products was lower than that of β-sitosterol in all patients; in vitro, 5β-reduction of both sterols was similar. The recovery of sterols from patients was unrelated to their 5β-reduction in the intestine.</abstract><cop>Switzerland</cop><pub>S. Karger</pub><pmid>1165855</pmid><tpages>8</tpages></addata></record> |
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| ispartof | Nutrition and metabolism (Basel), 1975, Vol.18 (1), p.23-30 |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Cholesterol - analogs & derivatives Cholesterol, Dietary - metabolism Chromium - analysis Feces - chemistry human nutrition Humans Hyperlipidemias - metabolism Intestines - metabolism nutrition education Original Papers Phytosterols - metabolism Sitosterols - metabolism |
| title | Human intestinal specificity toward dietary sterols studied by balance methods |
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