Ortho-phenanthroline inhibition of DNA synthesis in mammalian cells

Ortho-phenanthroline (OP) inhibits DNA synthesis in cultures of eukaryotic cells. After 6 h of exposure of L1210 leukemic cells to 5 μM OP, DNA synthesis was virtually stopped while RNA and protein synthesis remained at 82 and 70% of control levels. When normal human lymphocytes were stimulated by p...

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Veröffentlicht in:	Experimental cell research 1975-11, Vol.96 (1), p.145-155
Hauptverfasser:	Berger, N.A., Johnson, Elizabeth S., Skinner, Sr Ann Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cobalt - pharmacology Cycloheximide - pharmacology Dactinomycin - pharmacology DNA Replication - drug effects Lectins - metabolism Leukemia L1210 Mice Mice, Inbred Strains Nickel - pharmacology Phenanthrolines - pharmacology Protein Biosynthesis RNA - biosynthesis Thymidine - metabolism
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