Evidence for the Existence of Definitive Hepatic Cholesterol Precursor Compartments for Bile Acids and Biliary Cholesterol in Man
A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursorproduct...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1975-12, Vol.69 (6), p.1379-1382 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
| container_volume | 69 |
| creator | Schwartz, C.C. Vlahcevic, Z.R. Halloran, L.G. Gregory, D.H. Meek, J.B. Swell, Leon |
| description | A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursorproduct relationship between biliary cholesterol, plasma free cholesterol and bile acids. Both the constant infusion and pulse labeling data indicated that the bile acid precursor had a more rapid rate of turnover than plasma or biliary cholesterol; the biliary cholesterol precursor turned over more rapidly than plasma cholesterol. The data suggest the presence of multiple hepatic cholesterol precursor compartments. Bile acids may be derived predominantly from newly synthesized cholesterol in man. |
| doi_str_mv | 10.1016/S0016-5085(19)32342-X |
| format | Article |
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Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursorproduct relationship between biliary cholesterol, plasma free cholesterol and bile acids. Both the constant infusion and pulse labeling data indicated that the bile acid precursor had a more rapid rate of turnover than plasma or biliary cholesterol; the biliary cholesterol precursor turned over more rapidly than plasma cholesterol. The data suggest the presence of multiple hepatic cholesterol precursor compartments. Bile acids may be derived predominantly from newly synthesized cholesterol in man.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/S0016-5085(19)32342-X</identifier><identifier>PMID: 1193340</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bile Acids and Salts - metabolism ; Biliary Fistula - metabolism ; Cholesterol - biosynthesis ; Humans ; Liver - metabolism ; Male ; Mevalonic Acid - metabolism ; Middle Aged</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1975-12, Vol.69 (6), p.1379-1382</ispartof><rights>1975 AGA Institute</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-5201b6883886a2bf7e7e1eb97bca7179b4736928b8da622cb3d8d28cdcf59dfa3</citedby><cites>FETCH-LOGICAL-c407t-5201b6883886a2bf7e7e1eb97bca7179b4736928b8da622cb3d8d28cdcf59dfa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0016-5085(19)32342-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1193340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwartz, C.C.</creatorcontrib><creatorcontrib>Vlahcevic, Z.R.</creatorcontrib><creatorcontrib>Halloran, L.G.</creatorcontrib><creatorcontrib>Gregory, D.H.</creatorcontrib><creatorcontrib>Meek, J.B.</creatorcontrib><creatorcontrib>Swell, Leon</creatorcontrib><title>Evidence for the Existence of Definitive Hepatic Cholesterol Precursor Compartments for Bile Acids and Biliary Cholesterol in Man</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursorproduct relationship between biliary cholesterol, plasma free cholesterol and bile acids. Both the constant infusion and pulse labeling data indicated that the bile acid precursor had a more rapid rate of turnover than plasma or biliary cholesterol; the biliary cholesterol precursor turned over more rapidly than plasma cholesterol. The data suggest the presence of multiple hepatic cholesterol precursor compartments. Bile acids may be derived predominantly from newly synthesized cholesterol in man.</description><subject>Bile Acids and Salts - metabolism</subject><subject>Biliary Fistula - metabolism</subject><subject>Cholesterol - biosynthesis</subject><subject>Humans</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Mevalonic Acid - metabolism</subject><subject>Middle Aged</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMoWqs_QchKdDGaR2cmWYnW-gBFQQV3IZPcwcjMpCbTokv_uWkriishJCTnnHtvPoT2KDmihBbHDyTtWU5EfkDlIWd8xLLnNTSgORNZ0tg6GvxYttB2jK-EEMkF3USblErOR2SAPidzZ6EzgGsfcP8CePLuYr988TU-h9p1rndzwFcw1b0zePziG0iO4Bt8H8DMQkzJsW-nOvQtdH1cljpzDeBT42zEurOLq9Ph40_adfhWdztoo9ZNhN3vc4ieLiaP46vs5u7yenx6k5kRKfssZ4RWhRBciEKzqi6hBAqVLCujS1rKalTyQjJRCasLxkzFrbBMGGvqXNpa8yHaX9WdBv82SzOo1kUDTaM78LOoBJMl5WkNUb4ymuBjDFCraXBtGl5Rohbo1RK9WnBVVKolevWccnvfDWZVC_Y3tWKd9JOVDumXcwdBReMWoK1LGHtlvfunwxfmo5VU</recordid><startdate>197512</startdate><enddate>197512</enddate><creator>Schwartz, C.C.</creator><creator>Vlahcevic, Z.R.</creator><creator>Halloran, L.G.</creator><creator>Gregory, D.H.</creator><creator>Meek, J.B.</creator><creator>Swell, Leon</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197512</creationdate><title>Evidence for the Existence of Definitive Hepatic Cholesterol Precursor Compartments for Bile Acids and Biliary Cholesterol in Man</title><author>Schwartz, C.C. ; Vlahcevic, Z.R. ; Halloran, L.G. ; Gregory, D.H. ; Meek, J.B. ; Swell, Leon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-5201b6883886a2bf7e7e1eb97bca7179b4736928b8da622cb3d8d28cdcf59dfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Bile Acids and Salts - metabolism</topic><topic>Biliary Fistula - metabolism</topic><topic>Cholesterol - biosynthesis</topic><topic>Humans</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Mevalonic Acid - metabolism</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwartz, C.C.</creatorcontrib><creatorcontrib>Vlahcevic, Z.R.</creatorcontrib><creatorcontrib>Halloran, L.G.</creatorcontrib><creatorcontrib>Gregory, D.H.</creatorcontrib><creatorcontrib>Meek, J.B.</creatorcontrib><creatorcontrib>Swell, Leon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwartz, C.C.</au><au>Vlahcevic, Z.R.</au><au>Halloran, L.G.</au><au>Gregory, D.H.</au><au>Meek, J.B.</au><au>Swell, Leon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for the Existence of Definitive Hepatic Cholesterol Precursor Compartments for Bile Acids and Biliary Cholesterol in Man</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1975-12</date><risdate>1975</risdate><volume>69</volume><issue>6</issue><spage>1379</spage><epage>1382</epage><pages>1379-1382</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><abstract>A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursorproduct relationship between biliary cholesterol, plasma free cholesterol and bile acids. Both the constant infusion and pulse labeling data indicated that the bile acid precursor had a more rapid rate of turnover than plasma or biliary cholesterol; the biliary cholesterol precursor turned over more rapidly than plasma cholesterol. The data suggest the presence of multiple hepatic cholesterol precursor compartments. Bile acids may be derived predominantly from newly synthesized cholesterol in man.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1193340</pmid><doi>10.1016/S0016-5085(19)32342-X</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-5085 |
| ispartof | Gastroenterology (New York, N.Y. 1943), 1975-12, Vol.69 (6), p.1379-1382 |
| issn | 0016-5085 1528-0012 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82971371 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection |
| subjects | Bile Acids and Salts - metabolism Biliary Fistula - metabolism Cholesterol - biosynthesis Humans Liver - metabolism Male Mevalonic Acid - metabolism Middle Aged |
| title | Evidence for the Existence of Definitive Hepatic Cholesterol Precursor Compartments for Bile Acids and Biliary Cholesterol in Man |
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