Changes in Canine Gastric Acid Output and Serum Gastrin Levels Following Massive Small Intestinal Resection
Vagally denervated (Heidenhain) pouch acid outputs and serum gastrin concentrations, basal and in response to feeding, were measured in dogs before and after massive intestinal resection. Both 24-hr and postprandial Heidenhain pouch acid outputs increased (P < 0.01) after intestinal resection. In...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1975-08, Vol.69 (2), p.448-452 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Wickbom, Gunnar Landor, John H. Bushkin, Frederick L. McGuigan, James E. |
| description | Vagally denervated (Heidenhain) pouch acid outputs and serum gastrin concentrations, basal and in response to feeding, were measured in dogs before and after massive intestinal resection. Both 24-hr and postprandial Heidenhain pouch acid outputs increased (P < 0.01) after intestinal resection. Increases in serum gastrin concentrations following feeding were greater after massive resection of the small intestine. There was an excellent correlation (r = 0.967; P < 0.005) between increases in serum gastrin concentrations and Heidenhain pouch acid outputs after intestinal resection. These studies support and are consistent with the hypothesis that the polypeptide hormone gastrin plays a role in the production of the gastric acid hypersecretion which, in both dogs and man, frequently results from massive resection of the small intestine. |
| doi_str_mv | 10.1016/S0016-5085(19)32587-9 |
| format | Article |
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Both 24-hr and postprandial Heidenhain pouch acid outputs increased (P < 0.01) after intestinal resection. Increases in serum gastrin concentrations following feeding were greater after massive resection of the small intestine. There was an excellent correlation (r = 0.967; P < 0.005) between increases in serum gastrin concentrations and Heidenhain pouch acid outputs after intestinal resection. These studies support and are consistent with the hypothesis that the polypeptide hormone gastrin plays a role in the production of the gastric acid hypersecretion which, in both dogs and man, frequently results from massive resection of the small intestine.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/S0016-5085(19)32587-9</identifier><identifier>PMID: 1150049</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Dogs ; Eating ; Fasting ; Gastric Juice - secretion ; Gastrins - blood ; Intestine, Small - surgery ; Time Factors</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1975-08, Vol.69 (2), p.448-452</ispartof><rights>1975 AGA Institute</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-d40bc303511d478c7fec020c455c0e91119ea4468f2c2bc524d564a409409fd93</citedby><cites>FETCH-LOGICAL-c473t-d40bc303511d478c7fec020c455c0e91119ea4468f2c2bc524d564a409409fd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0016508519325879$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1150049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wickbom, Gunnar</creatorcontrib><creatorcontrib>Landor, John H.</creatorcontrib><creatorcontrib>Bushkin, Frederick L.</creatorcontrib><creatorcontrib>McGuigan, James E.</creatorcontrib><title>Changes in Canine Gastric Acid Output and Serum Gastrin Levels Following Massive Small Intestinal Resection</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>Vagally denervated (Heidenhain) pouch acid outputs and serum gastrin concentrations, basal and in response to feeding, were measured in dogs before and after massive intestinal resection. Both 24-hr and postprandial Heidenhain pouch acid outputs increased (P < 0.01) after intestinal resection. Increases in serum gastrin concentrations following feeding were greater after massive resection of the small intestine. There was an excellent correlation (r = 0.967; P < 0.005) between increases in serum gastrin concentrations and Heidenhain pouch acid outputs after intestinal resection. These studies support and are consistent with the hypothesis that the polypeptide hormone gastrin plays a role in the production of the gastric acid hypersecretion which, in both dogs and man, frequently results from massive resection of the small intestine.</description><subject>Animals</subject><subject>Dogs</subject><subject>Eating</subject><subject>Fasting</subject><subject>Gastric Juice - secretion</subject><subject>Gastrins - blood</subject><subject>Intestine, Small - surgery</subject><subject>Time Factors</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWj9-gpCT6GE12U26m5NI0SpUClbPIU1mNZrN1mS34r83_UCPwjBzeN-Zd3gQOqXkkhI6vJqR1DNOKn5OxUWR86rMxA4aUJ5XWdLyXTT4tRygwxjfCSGiqOg-2qeUE8LEAH2M3pR_hYitxyPlrQc8VrELVuMbbQ2e9t2i77DyBs8g9M1W9XgCS3AR37XOtV_Wv-JHFaNdAp41yjn84DuInfXK4SeIoDvb-mO0VysX4WQ7j9DL3e3z6D6bTMcPo5tJpllZdJlhZK4LUnBKDSsrXdagSU4041wTEJRSAYqxYVXnOp9rnjPDh0wxIlLVRhRH6GxzdxHazz69IRsbNTinPLR9lFUueAJTJiPfGHVoYwxQy0WwjQrfkhK5gizXkOWKoKRCriHLVcDpNqCfN2D-tjZUk3690RMhWFoIMmoLXoOxIaGQprX_JPwA6SqLrw</recordid><startdate>197508</startdate><enddate>197508</enddate><creator>Wickbom, Gunnar</creator><creator>Landor, John H.</creator><creator>Bushkin, Frederick L.</creator><creator>McGuigan, James E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197508</creationdate><title>Changes in Canine Gastric Acid Output and Serum Gastrin Levels Following Massive Small Intestinal Resection</title><author>Wickbom, Gunnar ; Landor, John H. ; Bushkin, Frederick L. ; McGuigan, James E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-d40bc303511d478c7fec020c455c0e91119ea4468f2c2bc524d564a409409fd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Dogs</topic><topic>Eating</topic><topic>Fasting</topic><topic>Gastric Juice - secretion</topic><topic>Gastrins - blood</topic><topic>Intestine, Small - surgery</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wickbom, Gunnar</creatorcontrib><creatorcontrib>Landor, John H.</creatorcontrib><creatorcontrib>Bushkin, Frederick L.</creatorcontrib><creatorcontrib>McGuigan, James E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wickbom, Gunnar</au><au>Landor, John H.</au><au>Bushkin, Frederick L.</au><au>McGuigan, James E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Canine Gastric Acid Output and Serum Gastrin Levels Following Massive Small Intestinal Resection</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1975-08</date><risdate>1975</risdate><volume>69</volume><issue>2</issue><spage>448</spage><epage>452</epage><pages>448-452</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><abstract>Vagally denervated (Heidenhain) pouch acid outputs and serum gastrin concentrations, basal and in response to feeding, were measured in dogs before and after massive intestinal resection. Both 24-hr and postprandial Heidenhain pouch acid outputs increased (P < 0.01) after intestinal resection. Increases in serum gastrin concentrations following feeding were greater after massive resection of the small intestine. There was an excellent correlation (r = 0.967; P < 0.005) between increases in serum gastrin concentrations and Heidenhain pouch acid outputs after intestinal resection. These studies support and are consistent with the hypothesis that the polypeptide hormone gastrin plays a role in the production of the gastric acid hypersecretion which, in both dogs and man, frequently results from massive resection of the small intestine.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1150049</pmid><doi>10.1016/S0016-5085(19)32587-9</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0016-5085 |
| ispartof | Gastroenterology (New York, N.Y. 1943), 1975-08, Vol.69 (2), p.448-452 |
| issn | 0016-5085 1528-0012 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Alma/SFX Local Collection |
| subjects | Animals Dogs Eating Fasting Gastric Juice - secretion Gastrins - blood Intestine, Small - surgery Time Factors |
| title | Changes in Canine Gastric Acid Output and Serum Gastrin Levels Following Massive Small Intestinal Resection |
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