The production of cobalt experimental epilepsy in the rat
Metallic cobalt powder applied to the cerebral cortex of the rat is a consistently effective method of producing a chronic epileptic discharging focus in this species. The ECoG changes consisted of slow waves, sharp waves and spikes and their climax was often accompanied by clonic movements of body...
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| Veröffentlicht in: | Electroencephalography and clinical neurophysiology 1962-06, Vol.14 (3), p.399-407 |
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| container_end_page | 407 |
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| container_issue | 3 |
| container_start_page | 399 |
| container_title | Electroencephalography and clinical neurophysiology |
| container_volume | 14 |
| creator | Dow, Robert S Fernández-Guardiola, Augusto Manni, Ermanno |
| description | Metallic cobalt powder applied to the cerebral cortex of the rat is a consistently effective method of producing a chronic epileptic discharging focus in this species.
The ECoG changes consisted of slow waves, sharp waves and spikes and their climax was often accompanied by clonic movements of body musculature. Audio- and photostimulation enhanced both clinical and ECoG manifestations. Possible mechanisms for the epileptic activity of this substance are discussed in the light of the histological changes which are described in detail. |
| doi_str_mv | 10.1016/0013-4694(62)90116-5 |
| format | Article |
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The ECoG changes consisted of slow waves, sharp waves and spikes and their climax was often accompanied by clonic movements of body musculature. Audio- and photostimulation enhanced both clinical and ECoG manifestations. Possible mechanisms for the epileptic activity of this substance are discussed in the light of the histological changes which are described in detail.</description><subject>Animals</subject><subject>Cobalt - pharmacology</subject><subject>Epilepsy</subject><subject>Old Medline</subject><subject>Rats</subject><issn>0013-4694</issn><issn>1872-6380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAURYMoOo7-A5GuRBfVfDfZCDL4BQNuxnVI01eMdNrapOL8e1Nn0J0hkM25L_cdhM4IviaYyBuMCcu51PxS0iuNCZG52EMzogqaS6bwPpr9IkfoOIR3jDEltDhER4QpVUgsZ0iv3iDrh64aXfRdm3V15rrSNjGDrx4Gv4Y22iaD3jfQh03m2yymxGDjCTqobRPgdPfO0evD_WrxlC9fHp8Xd8vcccpjqlKxVLfUhDAhSsZ1ScpKUCGcJoVUTkBFp8sF10XtynSYVZVQYFnhKJuji-3c1PJjhBDN2gcHTWNb6MZgFNVcUKUTyLegG7oQBqhNn_rbYWMINpMyM_kwkw8jqflRZkSKne_mj-Uaqr_QzlECbrcApC0_PQwmOA-tg8oP4KKpOv__D99P_Hnk</recordid><startdate>196206</startdate><enddate>196206</enddate><creator>Dow, Robert S</creator><creator>Fernández-Guardiola, Augusto</creator><creator>Manni, Ermanno</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196206</creationdate><title>The production of cobalt experimental epilepsy in the rat</title><author>Dow, Robert S ; Fernández-Guardiola, Augusto ; Manni, Ermanno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-63d3016b911355b349b1bd5255c91768c5ed2ed2e45497fcbbbb3a8d58ea37c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>Animals</topic><topic>Cobalt - pharmacology</topic><topic>Epilepsy</topic><topic>Old Medline</topic><topic>Rats</topic><toplevel>online_resources</toplevel><creatorcontrib>Dow, Robert S</creatorcontrib><creatorcontrib>Fernández-Guardiola, Augusto</creatorcontrib><creatorcontrib>Manni, Ermanno</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Electroencephalography and clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dow, Robert S</au><au>Fernández-Guardiola, Augusto</au><au>Manni, Ermanno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The production of cobalt experimental epilepsy in the rat</atitle><jtitle>Electroencephalography and clinical neurophysiology</jtitle><addtitle>Electroencephalogr Clin Neurophysiol</addtitle><date>1962-06</date><risdate>1962</risdate><volume>14</volume><issue>3</issue><spage>399</spage><epage>407</epage><pages>399-407</pages><issn>0013-4694</issn><eissn>1872-6380</eissn><abstract>Metallic cobalt powder applied to the cerebral cortex of the rat is a consistently effective method of producing a chronic epileptic discharging focus in this species.
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| fulltext | fulltext |
| identifier | ISSN: 0013-4694 |
| ispartof | Electroencephalography and clinical neurophysiology, 1962-06, Vol.14 (3), p.399-407 |
| issn | 0013-4694 1872-6380 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Cobalt - pharmacology Epilepsy Old Medline Rats |
| title | The production of cobalt experimental epilepsy in the rat |
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