Effects of Drug Vehicles on Ocular Uptake of Tetracycline

Varying concentrations of tetracycline hydrochloride were topically applied to the rabbit eye in several ophthalmic vehicles. The antibiotic levels in the corneal epithelium, aqueous humor, and lens were markedly elevated by increasing the drug concentration and the drug contact time with the eye. T...

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Veröffentlicht in:	American journal of ophthalmology 1975-07, Vol.80 (1), p.133-138
Hauptverfasser:	Hardberger, Rufus E., Hanna, Calvin, Goodart, Roy
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Topical Animals Anterior Chamber - metabolism Aqueous Humor - metabolism Bacteria - drug effects Cornea - metabolism Epithelium - metabolism Eye - metabolism Isotonic Solutions Lens, Crystalline - metabolism Methylcellulose - pharmacology Mineral Oil - metabolism Ointments Ophthalmic Solutions Petrolatum - metabolism Pharmaceutical Vehicles - pharmacology Polyvinyl Alcohol - pharmacology Rabbits Sodium Chloride - pharmacology Tetracycline - administration & dosage Tetracycline - metabolism Tetracycline - pharmacology
Online-Zugang:	Volltext
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