Penetration of antimicrobial agents into bronchial secretions
The entry of ampicillin, cephalothin and gentamicin into tracheobronchopulmonary secretions/exudates was assessed in 22 patients during 28 episodes of pneumonia or bronchitis. Specimens were collected from the lower respiratory tract via tracheostomies or endotracheal tubes using either the flexible...
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| Veröffentlicht in: | The American journal of medicine 1975-01, Vol.59 (2), p.219-223 |
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| container_title | The American journal of medicine |
| container_volume | 59 |
| creator | Wong, G.A. Peirce, T.H. Goldstein, E. Hoeprich, P.D. |
| description | The entry of ampicillin, cephalothin and gentamicin into tracheobronchopulmonary secretions/exudates was assessed in 22 patients during 28 episodes of pneumonia or bronchitis. Specimens were collected from the lower respiratory tract via tracheostomies or endotracheal tubes using either the flexible fiberoptic bronchoscope (50 specimens) or an intratracheal catheter (59 specimens). Venous blood was obtained at the same time.
The concentrations in the bronchial specimens were less than those in the corresponding serums, amounting to about 10 per cent with ampicillin, 25 per cent with cephalothin and equal to or greater than 40 per cent with gentamicin. |
| doi_str_mv | 10.1016/0002-9343(75)90356-3 |
| format | Article |
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The concentrations in the bronchial specimens were less than those in the corresponding serums, amounting to about 10 per cent with ampicillin, 25 per cent with cephalothin and equal to or greater than 40 per cent with gentamicin.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/0002-9343(75)90356-3</identifier><identifier>PMID: 1155479</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Ampicillin - metabolism ; Ampicillin - therapeutic use ; Bronchi - metabolism ; Bronchitis - blood ; Bronchitis - drug therapy ; Bronchoscopy ; Catheterization ; Cephalothin - metabolism ; Cephalothin - therapeutic use ; Exudates and Transudates - metabolism ; Fiber Optic Technology ; Gentamicins - metabolism ; Gentamicins - therapeutic use ; Humans ; Middle Aged ; Pneumonia - blood ; Pneumonia - drug therapy ; Proteins - metabolism ; Time Factors ; Trachea - metabolism</subject><ispartof>The American journal of medicine, 1975-01, Vol.59 (2), p.219-223</ispartof><rights>1975</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-eacef217f60c3b96d60dfe96ed173959ba80193e32def7818f43fe4f533969153</citedby><cites>FETCH-LOGICAL-c386t-eacef217f60c3b96d60dfe96ed173959ba80193e32def7818f43fe4f533969153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9343(75)90356-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1155479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, G.A.</creatorcontrib><creatorcontrib>Peirce, T.H.</creatorcontrib><creatorcontrib>Goldstein, E.</creatorcontrib><creatorcontrib>Hoeprich, P.D.</creatorcontrib><title>Penetration of antimicrobial agents into bronchial secretions</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>The entry of ampicillin, cephalothin and gentamicin into tracheobronchopulmonary secretions/exudates was assessed in 22 patients during 28 episodes of pneumonia or bronchitis. Specimens were collected from the lower respiratory tract via tracheostomies or endotracheal tubes using either the flexible fiberoptic bronchoscope (50 specimens) or an intratracheal catheter (59 specimens). Venous blood was obtained at the same time.
The concentrations in the bronchial specimens were less than those in the corresponding serums, amounting to about 10 per cent with ampicillin, 25 per cent with cephalothin and equal to or greater than 40 per cent with gentamicin.</description><subject>Adult</subject><subject>Aged</subject><subject>Ampicillin - metabolism</subject><subject>Ampicillin - therapeutic use</subject><subject>Bronchi - metabolism</subject><subject>Bronchitis - blood</subject><subject>Bronchitis - drug therapy</subject><subject>Bronchoscopy</subject><subject>Catheterization</subject><subject>Cephalothin - metabolism</subject><subject>Cephalothin - therapeutic use</subject><subject>Exudates and Transudates - metabolism</subject><subject>Fiber Optic Technology</subject><subject>Gentamicins - metabolism</subject><subject>Gentamicins - therapeutic use</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Pneumonia - blood</subject><subject>Pneumonia - drug therapy</subject><subject>Proteins - metabolism</subject><subject>Time Factors</subject><subject>Trachea - metabolism</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UE1LxDAQDaKs6-o_UOhJ9FBNmiZtDgqy-AULetBzSNOJRtpEk6zgv7e1i948DTPvY3gPoUOCzwgm_BxjXOSClvSkYqcCU8ZzuoXmhDGWV4QX22j-S9lFezG-DSsWjM_QjAysshJzdPEIDlJQyXqXeZMpl2xvdfCNVV2mXsClmFmXfNYE7_TreI2gA4yCuI92jOoiHGzmAj3fXD8t7_LVw-398mqVa1rzlIPSYApSGY41bQRvOW4NCA4tqahgolE1JoICLVowVU1qU1IDpWGUCi4Iowt0PPm-B_-xhphkb6OGrlMO_DrKuhBlMeZcoHIiDgliDGDke7C9Cl-SYDm2JsdK5EiVFZM_rUk6yI42_uumh_ZPNNU04JcTDkPITwtBRm3BaWhtAJ1k6-3_D74B9UB7ww</recordid><startdate>19750101</startdate><enddate>19750101</enddate><creator>Wong, G.A.</creator><creator>Peirce, T.H.</creator><creator>Goldstein, E.</creator><creator>Hoeprich, P.D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19750101</creationdate><title>Penetration of antimicrobial agents into bronchial secretions</title><author>Wong, G.A. ; Peirce, T.H. ; Goldstein, E. ; Hoeprich, P.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-eacef217f60c3b96d60dfe96ed173959ba80193e32def7818f43fe4f533969153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Ampicillin - metabolism</topic><topic>Ampicillin - therapeutic use</topic><topic>Bronchi - metabolism</topic><topic>Bronchitis - blood</topic><topic>Bronchitis - drug therapy</topic><topic>Bronchoscopy</topic><topic>Catheterization</topic><topic>Cephalothin - metabolism</topic><topic>Cephalothin - therapeutic use</topic><topic>Exudates and Transudates - metabolism</topic><topic>Fiber Optic Technology</topic><topic>Gentamicins - metabolism</topic><topic>Gentamicins - therapeutic use</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Pneumonia - blood</topic><topic>Pneumonia - drug therapy</topic><topic>Proteins - metabolism</topic><topic>Time Factors</topic><topic>Trachea - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, G.A.</creatorcontrib><creatorcontrib>Peirce, T.H.</creatorcontrib><creatorcontrib>Goldstein, E.</creatorcontrib><creatorcontrib>Hoeprich, P.D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, G.A.</au><au>Peirce, T.H.</au><au>Goldstein, E.</au><au>Hoeprich, P.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Penetration of antimicrobial agents into bronchial secretions</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1975-01-01</date><risdate>1975</risdate><volume>59</volume><issue>2</issue><spage>219</spage><epage>223</epage><pages>219-223</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>The entry of ampicillin, cephalothin and gentamicin into tracheobronchopulmonary secretions/exudates was assessed in 22 patients during 28 episodes of pneumonia or bronchitis. Specimens were collected from the lower respiratory tract via tracheostomies or endotracheal tubes using either the flexible fiberoptic bronchoscope (50 specimens) or an intratracheal catheter (59 specimens). Venous blood was obtained at the same time.
The concentrations in the bronchial specimens were less than those in the corresponding serums, amounting to about 10 per cent with ampicillin, 25 per cent with cephalothin and equal to or greater than 40 per cent with gentamicin.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1155479</pmid><doi>10.1016/0002-9343(75)90356-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | The American journal of medicine, 1975-01, Vol.59 (2), p.219-223 |
| issn | 0002-9343 1555-7162 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged Ampicillin - metabolism Ampicillin - therapeutic use Bronchi - metabolism Bronchitis - blood Bronchitis - drug therapy Bronchoscopy Catheterization Cephalothin - metabolism Cephalothin - therapeutic use Exudates and Transudates - metabolism Fiber Optic Technology Gentamicins - metabolism Gentamicins - therapeutic use Humans Middle Aged Pneumonia - blood Pneumonia - drug therapy Proteins - metabolism Time Factors Trachea - metabolism |
| title | Penetration of antimicrobial agents into bronchial secretions |
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