Synthesis and antibacterial activities of some chloro analogs of 3-amino-3,4-dihydro-1-hydroxycarbostyril

The effects of a chloro substituent upon the microbiological activities of 3-amino-3,4-dihydro-1-hydroxycarbostyril were determined. The 5-, 6-, and 7-chloro analogs were synthesized by reductive cyclizations of the appropriately chloro-substituted o-nitrophenylalanines, while the 8-chloro analog wa...

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Veröffentlicht in:	Journal of medicinal chemistry 1975-07, Vol.18 (7), p.752-755
Hauptverfasser:	Davis, Alvie L, Chambers, William H, Kelley, Don H, Fell, David A, Haynes, John R, Hulme, Karen L, Gage, Larry D, McCord, Tommy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Escherichia coli - drug effects Hydroxyquinolines - chemical synthesis Lactobacillus - drug effects Leuconostoc - drug effects Microbial Sensitivity Tests Piperidines - chemical synthesis Piperidones - chemical synthesis Piperidones - pharmacology
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