Serum prolactin levels of rats under continuous estrogen stimulation and 2 Br-alpha-ergocryptine (CB-154) injection
The ability of 2 Br-alpha-ergocryptine (CB-154) to suppress serum prolactin levels was examined in animals under the influence of continuous estrogen stimulation. A single injection of polyestradiol phosphate (Estradurin) once every 21 days produced a constant elevation of serum prolactin. The simul...
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| Veröffentlicht in: | Proceedings of the Society for Experimental Biology and Medicine 1975-06, Vol.149 (2), p.330-332 |
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| container_title | Proceedings of the Society for Experimental Biology and Medicine |
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| creator | Gala, R R Boss, R S |
| description | The ability of 2 Br-alpha-ergocryptine (CB-154) to suppress serum prolactin levels was examined in animals under the influence of continuous estrogen stimulation. A single injection of polyestradiol phosphate (Estradurin) once every 21 days produced a constant elevation of serum prolactin. The simultaneous administration of 1 mg/day of CB-154 to estrogenized animals suppressed serum prolactin levels below that of Estradurin alone but the levels were significantly greater than those of animals receiving CB-154 alone. It was suggested that, while CB-154 prevents the release of prolactin, estrogen stimulates prolactin synthesis despite the block of its release. Ether anesthesia may be capable of partially overriding the block of CB-154 and released the stored hormone from the gland. |
| doi_str_mv | 10.3181/00379727-149-38800 |
| format | Article |
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A single injection of polyestradiol phosphate (Estradurin) once every 21 days produced a constant elevation of serum prolactin. The simultaneous administration of 1 mg/day of CB-154 to estrogenized animals suppressed serum prolactin levels below that of Estradurin alone but the levels were significantly greater than those of animals receiving CB-154 alone. It was suggested that, while CB-154 prevents the release of prolactin, estrogen stimulates prolactin synthesis despite the block of its release. Ether anesthesia may be capable of partially overriding the block of CB-154 and released the stored hormone from the gland.</description><identifier>ISSN: 0037-9727</identifier><identifier>DOI: 10.3181/00379727-149-38800</identifier><identifier>PMID: 1153405</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Body Weight ; Bromocriptine - pharmacology ; Castration ; Depression, Chemical ; Ergolines - pharmacology ; Estradiol - analogs & derivatives ; Estradiol - pharmacology ; Female ; Injections, Subcutaneous ; Organ Size ; Organophosphorus Compounds - pharmacology ; Ovary - physiology ; Polymers - pharmacology ; Prolactin - blood ; Prolactin - metabolism ; Rats ; Stimulation, Chemical ; Tartrates - administration & dosage ; Time Factors ; Vaginal Smears</subject><ispartof>Proceedings of the Society for Experimental Biology and Medicine, 1975-06, Vol.149 (2), p.330-332</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1153405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gala, R R</creatorcontrib><creatorcontrib>Boss, R S</creatorcontrib><title>Serum prolactin levels of rats under continuous estrogen stimulation and 2 Br-alpha-ergocryptine (CB-154) injection</title><title>Proceedings of the Society for Experimental Biology and Medicine</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>The ability of 2 Br-alpha-ergocryptine (CB-154) to suppress serum prolactin levels was examined in animals under the influence of continuous estrogen stimulation. A single injection of polyestradiol phosphate (Estradurin) once every 21 days produced a constant elevation of serum prolactin. The simultaneous administration of 1 mg/day of CB-154 to estrogenized animals suppressed serum prolactin levels below that of Estradurin alone but the levels were significantly greater than those of animals receiving CB-154 alone. It was suggested that, while CB-154 prevents the release of prolactin, estrogen stimulates prolactin synthesis despite the block of its release. Ether anesthesia may be capable of partially overriding the block of CB-154 and released the stored hormone from the gland.</description><subject>Animals</subject><subject>Body Weight</subject><subject>Bromocriptine - pharmacology</subject><subject>Castration</subject><subject>Depression, Chemical</subject><subject>Ergolines - pharmacology</subject><subject>Estradiol - analogs & derivatives</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Injections, Subcutaneous</subject><subject>Organ Size</subject><subject>Organophosphorus Compounds - pharmacology</subject><subject>Ovary - physiology</subject><subject>Polymers - pharmacology</subject><subject>Prolactin - blood</subject><subject>Prolactin - metabolism</subject><subject>Rats</subject><subject>Stimulation, Chemical</subject><subject>Tartrates - administration & dosage</subject><subject>Time Factors</subject><subject>Vaginal Smears</subject><issn>0037-9727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkE9LxDAQxXNQ1nX1CwhCTqKH6KRJ0_ToLv6DBQ_quaTpdO2SpjVphf32drGngTe_ebw3hFxxuBdc8wcAkeVZkjEucya0Bjghy6PIjuoZOY9xDwAKEliQBeepkJAuSfzAMLa0D50zdmg8dfiLLtKupsEMkY6-wkBt56fd2I2RYhxCt0NP49C0ozND03lqfEUTug7MuP7bMAy7zoZDP90gvd2sGU_lHW38Hu0RvyCntXERL-e5Il_PT5-bV7Z9f3nbPG5Zn4AaWCZTYVUujK25SktUyK1UWIHiqixTmUPNtQQhdWV0grbEsk5Kk2teVRJsJlbk5t93avczTsGLtokWnTMepyqFTnLJM8kn8HoGx7LFquhD05pwKOYviT_cT2je</recordid><startdate>197506</startdate><enddate>197506</enddate><creator>Gala, R R</creator><creator>Boss, R S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197506</creationdate><title>Serum prolactin levels of rats under continuous estrogen stimulation and 2 Br-alpha-ergocryptine (CB-154) injection</title><author>Gala, R R ; Boss, R S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p206t-7453c693acf165be6e1c46ed0616bb5490f1840348da82ecbebf2ba981dd40c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Body Weight</topic><topic>Bromocriptine - pharmacology</topic><topic>Castration</topic><topic>Depression, Chemical</topic><topic>Ergolines - pharmacology</topic><topic>Estradiol - analogs & derivatives</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Injections, Subcutaneous</topic><topic>Organ Size</topic><topic>Organophosphorus Compounds - pharmacology</topic><topic>Ovary - physiology</topic><topic>Polymers - pharmacology</topic><topic>Prolactin - blood</topic><topic>Prolactin - metabolism</topic><topic>Rats</topic><topic>Stimulation, Chemical</topic><topic>Tartrates - administration & dosage</topic><topic>Time Factors</topic><topic>Vaginal Smears</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gala, R R</creatorcontrib><creatorcontrib>Boss, R S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Proceedings of the Society for Experimental Biology and Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gala, R R</au><au>Boss, R S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum prolactin levels of rats under continuous estrogen stimulation and 2 Br-alpha-ergocryptine (CB-154) injection</atitle><jtitle>Proceedings of the Society for Experimental Biology and Medicine</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1975-06</date><risdate>1975</risdate><volume>149</volume><issue>2</issue><spage>330</spage><epage>332</epage><pages>330-332</pages><issn>0037-9727</issn><abstract>The ability of 2 Br-alpha-ergocryptine (CB-154) to suppress serum prolactin levels was examined in animals under the influence of continuous estrogen stimulation. A single injection of polyestradiol phosphate (Estradurin) once every 21 days produced a constant elevation of serum prolactin. The simultaneous administration of 1 mg/day of CB-154 to estrogenized animals suppressed serum prolactin levels below that of Estradurin alone but the levels were significantly greater than those of animals receiving CB-154 alone. It was suggested that, while CB-154 prevents the release of prolactin, estrogen stimulates prolactin synthesis despite the block of its release. Ether anesthesia may be capable of partially overriding the block of CB-154 and released the stored hormone from the gland.</abstract><cop>United States</cop><pmid>1153405</pmid><doi>10.3181/00379727-149-38800</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Proceedings of the Society for Experimental Biology and Medicine, 1975-06, Vol.149 (2), p.330-332 |
| issn | 0037-9727 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Body Weight Bromocriptine - pharmacology Castration Depression, Chemical Ergolines - pharmacology Estradiol - analogs & derivatives Estradiol - pharmacology Female Injections, Subcutaneous Organ Size Organophosphorus Compounds - pharmacology Ovary - physiology Polymers - pharmacology Prolactin - blood Prolactin - metabolism Rats Stimulation, Chemical Tartrates - administration & dosage Time Factors Vaginal Smears |
| title | Serum prolactin levels of rats under continuous estrogen stimulation and 2 Br-alpha-ergocryptine (CB-154) injection |
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