A NEW PARENTERAL CEPHALOSPORIN. SK&F 59962: IN VITRO AND IN VIVO ANTIBACTERIAL ACTIVITY AND SERUM LEVELS IN EXPERIMENTAL ANIMALS
SK&F 59962, a new parenteral cephalosporin was found to have a high order of in vitro and in vivo antibacterial activity against a broad-spectrum of clinical isolates. When tested in vitro against gram-negative organisms, SK&F 59962 was consistently more active than cefazolin and far superio...
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| Veröffentlicht in: | Journal of antibiotics 1975, Vol.28(6), pp.471-476 |
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| container_issue | 6 |
| container_start_page | 471 |
| container_title | Journal of antibiotics |
| container_volume | 28 |
| creator | ACTOR, PAUL URI, JOSEPH V. GUARINI, JOSEPH R. ZAJAC, IHOR PHILLIPS, LILLIAN SACHS, CARL S. DEMARINIS, ROBERT M. HOOVER, JOHN R. E. WEISBACH, JERRY A. |
| description | SK&F 59962, a new parenteral cephalosporin was found to have a high order of in vitro and in vivo antibacterial activity against a broad-spectrum of clinical isolates. When tested in vitro against gram-negative organisms, SK&F 59962 was consistently more active than cefazolin and far superior to cephalothin. This new antibiotic had activity equal to that of cephalothin against gram-positive bacteria. Enterobacter species were found to be susceptible to SK&F 59962. In mouse infection studies using bacterial pathogens, SK&F 59962 had protective activity of the order of that of cefazolin and superior to that of cephalothin. Following parenteral administration the serum profile of SK&F 59962 in the mouse, dog and squirrel monkey was similar to that of cephalothin. SK&F 59962 and cephalothin had lower peak serum concentrations and shorter biologic half-lives than those of cefazolin. |
| doi_str_mv | 10.7164/antibiotics.28.471 |
| format | Article |
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SK&F 59962: IN VITRO AND IN VIVO ANTIBACTERIAL ACTIVITY AND SERUM LEVELS IN EXPERIMENTAL ANIMALS</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>ACTOR, PAUL ; URI, JOSEPH V. ; GUARINI, JOSEPH R. ; ZAJAC, IHOR ; PHILLIPS, LILLIAN ; SACHS, CARL S. ; DEMARINIS, ROBERT M. ; HOOVER, JOHN R. E. ; WEISBACH, JERRY A.</creator><creatorcontrib>ACTOR, PAUL ; URI, JOSEPH V. ; GUARINI, JOSEPH R. ; ZAJAC, IHOR ; PHILLIPS, LILLIAN ; SACHS, CARL S. ; DEMARINIS, ROBERT M. ; HOOVER, JOHN R. E. ; WEISBACH, JERRY A.</creatorcontrib><description><![CDATA[SK&F 59962, a new parenteral cephalosporin was found to have a high order of in vitro and in vivo antibacterial activity against a broad-spectrum of clinical isolates. When tested in vitro against gram-negative organisms, SK&F 59962 was consistently more active than cefazolin and far superior to cephalothin. This new antibiotic had activity equal to that of cephalothin against gram-positive bacteria. Enterobacter species were found to be susceptible to SK&F 59962. In mouse infection studies using bacterial pathogens, SK&F 59962 had protective activity of the order of that of cefazolin and superior to that of cephalothin. Following parenteral administration the serum profile of SK&F 59962 in the mouse, dog and squirrel monkey was similar to that of cephalothin. SK&F 59962 and cephalothin had lower peak serum concentrations and shorter biologic half-lives than those of cefazolin.]]></description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.28.471</identifier><identifier>PMID: 238925</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Cefazolin - pharmacology ; Cephalosporins - administration & dosage ; Cephalosporins - blood ; Cephalosporins - pharmacology ; Cephalothin - blood ; Cephalothin - pharmacology ; Dogs ; Enterobacteriaceae - drug effects ; Escherichia coli - drug effects ; Haemophilus influenzae - drug effects ; Haplorhini ; Injections, Intramuscular ; Injections, Subcutaneous ; Klebsiella pneumoniae - drug effects ; Mice ; Salmonella paratyphi A - drug effects ; Staphylococcus - drug effects</subject><ispartof>The Journal of Antibiotics, 1975, Vol.28(6), pp.471-476</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5161-c48d291f8d19187a1d611f042b5cc9b3e0d44b4b38c12a66079f3d9ad6f288653</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/238925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ACTOR, PAUL</creatorcontrib><creatorcontrib>URI, JOSEPH V.</creatorcontrib><creatorcontrib>GUARINI, JOSEPH R.</creatorcontrib><creatorcontrib>ZAJAC, IHOR</creatorcontrib><creatorcontrib>PHILLIPS, LILLIAN</creatorcontrib><creatorcontrib>SACHS, CARL S.</creatorcontrib><creatorcontrib>DEMARINIS, ROBERT M.</creatorcontrib><creatorcontrib>HOOVER, JOHN R. E.</creatorcontrib><creatorcontrib>WEISBACH, JERRY A.</creatorcontrib><title>A NEW PARENTERAL CEPHALOSPORIN. SK&F 59962: IN VITRO AND IN VIVO ANTIBACTERIAL ACTIVITY AND SERUM LEVELS IN EXPERIMENTAL ANIMALS</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description><![CDATA[SK&F 59962, a new parenteral cephalosporin was found to have a high order of in vitro and in vivo antibacterial activity against a broad-spectrum of clinical isolates. When tested in vitro against gram-negative organisms, SK&F 59962 was consistently more active than cefazolin and far superior to cephalothin. This new antibiotic had activity equal to that of cephalothin against gram-positive bacteria. Enterobacter species were found to be susceptible to SK&F 59962. In mouse infection studies using bacterial pathogens, SK&F 59962 had protective activity of the order of that of cefazolin and superior to that of cephalothin. Following parenteral administration the serum profile of SK&F 59962 in the mouse, dog and squirrel monkey was similar to that of cephalothin. SK&F 59962 and cephalothin had lower peak serum concentrations and shorter biologic half-lives than those of cefazolin.]]></description><subject>Animals</subject><subject>Cefazolin - pharmacology</subject><subject>Cephalosporins - administration & dosage</subject><subject>Cephalosporins - blood</subject><subject>Cephalosporins - pharmacology</subject><subject>Cephalothin - blood</subject><subject>Cephalothin - pharmacology</subject><subject>Dogs</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Escherichia coli - drug effects</subject><subject>Haemophilus influenzae - drug effects</subject><subject>Haplorhini</subject><subject>Injections, Intramuscular</subject><subject>Injections, Subcutaneous</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Mice</subject><subject>Salmonella paratyphi A - drug effects</subject><subject>Staphylococcus - drug effects</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkL1u2zAUhYmif27SFyg6cMomh5eSKLKb6jKJEFk2JMdtJ4KiqFaBf1LRHrrl0UNFgZGFvMT9zkfgIPQFyDQBFl3q3aGru_2hM25K-TRK4A2aAOcQQMTEWzQhhELAOSUf0Sfn7gkJkzDhH9B7GnJB4wl6THEhf-JlWspiJcs0xzO5vEnzRbVclFkxxdXtxRWOhWD0G84KvM5W5QKnxY_xsR7mVfY9nflw5tN-yDzz-xmpZHk3x7lcy7waePlr6am5_2kgi2ye5tU5etfqjbOfX-4zdHclV7ObIF9cZ7M0D0wMDAIT8YYKaHkDAniioWEALYloHRsj6tCSJorqqA65AaoZI4low0bohrWUcxaHZ-hi9D70-39H6w5q2zljNxu9s_ujU5wKysNYeJCOoOn3zvW2VQ99t9X9fwVEDa2rV60rypVv3Ye-vtiP9dY2p8hYs1_fjut7d9B_7Gmtey_Z2NdGEIwPVjYeXn6izF_dK7sLnwBPx5CL</recordid><startdate>1975</startdate><enddate>1975</enddate><creator>ACTOR, PAUL</creator><creator>URI, JOSEPH V.</creator><creator>GUARINI, JOSEPH R.</creator><creator>ZAJAC, IHOR</creator><creator>PHILLIPS, LILLIAN</creator><creator>SACHS, CARL S.</creator><creator>DEMARINIS, ROBERT M.</creator><creator>HOOVER, JOHN R. E.</creator><creator>WEISBACH, JERRY A.</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1975</creationdate><title>A NEW PARENTERAL CEPHALOSPORIN. SK&F 59962: IN VITRO AND IN VIVO ANTIBACTERIAL ACTIVITY AND SERUM LEVELS IN EXPERIMENTAL ANIMALS</title><author>ACTOR, PAUL ; URI, JOSEPH V. ; GUARINI, JOSEPH R. ; ZAJAC, IHOR ; PHILLIPS, LILLIAN ; SACHS, CARL S. ; DEMARINIS, ROBERT M. ; HOOVER, JOHN R. E. ; WEISBACH, JERRY A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5161-c48d291f8d19187a1d611f042b5cc9b3e0d44b4b38c12a66079f3d9ad6f288653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Cefazolin - pharmacology</topic><topic>Cephalosporins - administration & dosage</topic><topic>Cephalosporins - blood</topic><topic>Cephalosporins - pharmacology</topic><topic>Cephalothin - blood</topic><topic>Cephalothin - pharmacology</topic><topic>Dogs</topic><topic>Enterobacteriaceae - drug effects</topic><topic>Escherichia coli - drug effects</topic><topic>Haemophilus influenzae - drug effects</topic><topic>Haplorhini</topic><topic>Injections, Intramuscular</topic><topic>Injections, Subcutaneous</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Mice</topic><topic>Salmonella paratyphi A - drug effects</topic><topic>Staphylococcus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ACTOR, PAUL</creatorcontrib><creatorcontrib>URI, JOSEPH V.</creatorcontrib><creatorcontrib>GUARINI, JOSEPH R.</creatorcontrib><creatorcontrib>ZAJAC, IHOR</creatorcontrib><creatorcontrib>PHILLIPS, LILLIAN</creatorcontrib><creatorcontrib>SACHS, CARL S.</creatorcontrib><creatorcontrib>DEMARINIS, ROBERT M.</creatorcontrib><creatorcontrib>HOOVER, JOHN R. E.</creatorcontrib><creatorcontrib>WEISBACH, JERRY A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ACTOR, PAUL</au><au>URI, JOSEPH V.</au><au>GUARINI, JOSEPH R.</au><au>ZAJAC, IHOR</au><au>PHILLIPS, LILLIAN</au><au>SACHS, CARL S.</au><au>DEMARINIS, ROBERT M.</au><au>HOOVER, JOHN R. E.</au><au>WEISBACH, JERRY A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A NEW PARENTERAL CEPHALOSPORIN. SK&F 59962: IN VITRO AND IN VIVO ANTIBACTERIAL ACTIVITY AND SERUM LEVELS IN EXPERIMENTAL ANIMALS</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1975</date><risdate>1975</risdate><volume>28</volume><issue>6</issue><spage>471</spage><epage>476</epage><pages>471-476</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract><![CDATA[SK&F 59962, a new parenteral cephalosporin was found to have a high order of in vitro and in vivo antibacterial activity against a broad-spectrum of clinical isolates. When tested in vitro against gram-negative organisms, SK&F 59962 was consistently more active than cefazolin and far superior to cephalothin. This new antibiotic had activity equal to that of cephalothin against gram-positive bacteria. Enterobacter species were found to be susceptible to SK&F 59962. In mouse infection studies using bacterial pathogens, SK&F 59962 had protective activity of the order of that of cefazolin and superior to that of cephalothin. Following parenteral administration the serum profile of SK&F 59962 in the mouse, dog and squirrel monkey was similar to that of cephalothin. SK&F 59962 and cephalothin had lower peak serum concentrations and shorter biologic half-lives than those of cefazolin.]]></abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>238925</pmid><doi>10.7164/antibiotics.28.471</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1975, Vol.28(6), pp.471-476 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Animals Cefazolin - pharmacology Cephalosporins - administration & dosage Cephalosporins - blood Cephalosporins - pharmacology Cephalothin - blood Cephalothin - pharmacology Dogs Enterobacteriaceae - drug effects Escherichia coli - drug effects Haemophilus influenzae - drug effects Haplorhini Injections, Intramuscular Injections, Subcutaneous Klebsiella pneumoniae - drug effects Mice Salmonella paratyphi A - drug effects Staphylococcus - drug effects |
| title | A NEW PARENTERAL CEPHALOSPORIN. SK&F 59962: IN VITRO AND IN VIVO ANTIBACTERIAL ACTIVITY AND SERUM LEVELS IN EXPERIMENTAL ANIMALS |
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