Immunology of cartilage in septic arthritis
Septic arthritis in one knee joint was produced in 18 rabbits, the contralateral knee being left intact. Sections stained with fluorescein conjugated anti-IgG and with fluorescein conjugated anti-IgM showed layers of immunoglobulins on the articular cartilage in 16 out of 17 injected joints, and 10...
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| Veröffentlicht in: | Clinical orthopaedics and related research 1975-05, Vol.108 (108), p.84-89 |
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| container_title | Clinical orthopaedics and related research |
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| creator | Bobechko, W P Mandell, L |
| description | Septic arthritis in one knee joint was produced in 18 rabbits, the contralateral knee being left intact. Sections stained with fluorescein conjugated anti-IgG and with fluorescein conjugated anti-IgM showed layers of immunoglobulins on the articular cartilage in 16 out of 17 injected joints, and 10 out of 17 supposedly "normal" knee joints. Concurrent tests for circulating anti-staphylococcal alpha-lysin gave negative results. Cultures of synovial fluids were negative. These observations suggest that articular cartilage may act as an auto-antigen; immunological mechanisms involved may be due to the combined activity of both cell-bound and humoral antibodies. There are 2 components to a septic arthritis, the primary being a bacterial and the secondary immunologic in nature. |
| doi_str_mv | 10.1097/00003086-197505000-00013 |
| format | Article |
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Sections stained with fluorescein conjugated anti-IgG and with fluorescein conjugated anti-IgM showed layers of immunoglobulins on the articular cartilage in 16 out of 17 injected joints, and 10 out of 17 supposedly "normal" knee joints. Concurrent tests for circulating anti-staphylococcal alpha-lysin gave negative results. Cultures of synovial fluids were negative. These observations suggest that articular cartilage may act as an auto-antigen; immunological mechanisms involved may be due to the combined activity of both cell-bound and humoral antibodies. 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Sections stained with fluorescein conjugated anti-IgG and with fluorescein conjugated anti-IgM showed layers of immunoglobulins on the articular cartilage in 16 out of 17 injected joints, and 10 out of 17 supposedly "normal" knee joints. Concurrent tests for circulating anti-staphylococcal alpha-lysin gave negative results. Cultures of synovial fluids were negative. These observations suggest that articular cartilage may act as an auto-antigen; immunological mechanisms involved may be due to the combined activity of both cell-bound and humoral antibodies. 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| ispartof | Clinical orthopaedics and related research, 1975-05, Vol.108 (108), p.84-89 |
| issn | 0009-921X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Antibodies, Bacterial Antibody Formation Arthritis, Infectious - immunology Autoantigens Cartilage, Articular - immunology Fluorescent Antibody Technique Immunity Immunity, Cellular Knee Joint - immunology Microscopy, Ultraviolet Rabbits Staphylococcal Infections - immunology |
| title | Immunology of cartilage in septic arthritis |
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