Depression, Delusions, and Drug Response
Depressed patients with delusions were found to be markedly unresponsive to tricyclic drug therapy during an ongoing study of depressed patients. After four weeks of administration of imipramine hydrochloride, only 3 of 13 delusional depressed patients had responded to the drug, but 14 of 21 nondelu...
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| Veröffentlicht in: | The American journal of psychiatry 1975-07, Vol.132 (7), p.716-719 |
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| container_title | The American journal of psychiatry |
| container_volume | 132 |
| creator | Glassman, A H Kantor, S J Shostak, M |
| description | Depressed patients with delusions were found to be markedly unresponsive
to tricyclic drug therapy during an ongoing study of depressed patients.
After four weeks of administration of imipramine hydrochloride, only 3 of
13 delusional depressed patients had responded to the drug, but 14 of 21
nondelusional depressed patients had responded. The authors conclude on the
basis of these data and those of other researchers that delusional
depressed patients should not be treated with tricyclic antidepressants and
that current research with depressed patients should be reevaluated in the
light of this finding. |
| doi_str_mv | 10.1176/ajp.132.7.716 |
| format | Article |
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to tricyclic drug therapy during an ongoing study of depressed patients.
After four weeks of administration of imipramine hydrochloride, only 3 of
13 delusional depressed patients had responded to the drug, but 14 of 21
nondelusional depressed patients had responded. The authors conclude on the
basis of these data and those of other researchers that delusional
depressed patients should not be treated with tricyclic antidepressants and
that current research with depressed patients should be reevaluated in the
light of this finding.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.132.7.716</identifier><identifier>PMID: 1094841</identifier><language>eng</language><publisher>United States: American Psychiatric Publishing</publisher><subject>Adult ; Amitriptyline - therapeutic use ; Antidepressive Agents, Tricyclic - therapeutic use ; Clinical Trials as Topic ; Delusions - complications ; Delusions - diagnosis ; Delusions - drug therapy ; Depression - complications ; Depression - diagnosis ; Depression - drug therapy ; Drug Evaluation ; Female ; Humans ; Imipramine - therapeutic use ; Male ; Middle Aged ; Placebos ; Psychological Tests ; Remission, Spontaneous ; Sex Factors</subject><ispartof>The American journal of psychiatry, 1975-07, Vol.132 (7), p.716-719</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a351t-be3fdda560c9731af2211ec059546b64937c8c5fada4a83475b5a3f6e95a13283</citedby><cites>FETCH-LOGICAL-a351t-be3fdda560c9731af2211ec059546b64937c8c5fada4a83475b5a3f6e95a13283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.132.7.716$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.132.7.716$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2845,21609,27848,27903,27904,77537,77538</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1094841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Glassman, A H</creatorcontrib><creatorcontrib>Kantor, S J</creatorcontrib><creatorcontrib>Shostak, M</creatorcontrib><title>Depression, Delusions, and Drug Response</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>Depressed patients with delusions were found to be markedly unresponsive
to tricyclic drug therapy during an ongoing study of depressed patients.
After four weeks of administration of imipramine hydrochloride, only 3 of
13 delusional depressed patients had responded to the drug, but 14 of 21
nondelusional depressed patients had responded. The authors conclude on the
basis of these data and those of other researchers that delusional
depressed patients should not be treated with tricyclic antidepressants and
that current research with depressed patients should be reevaluated in the
light of this finding.</description><subject>Adult</subject><subject>Amitriptyline - therapeutic use</subject><subject>Antidepressive Agents, Tricyclic - therapeutic use</subject><subject>Clinical Trials as Topic</subject><subject>Delusions - complications</subject><subject>Delusions - diagnosis</subject><subject>Delusions - drug therapy</subject><subject>Depression - complications</subject><subject>Depression - diagnosis</subject><subject>Depression - drug therapy</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Imipramine - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Placebos</subject><subject>Psychological Tests</subject><subject>Remission, Spontaneous</subject><subject>Sex Factors</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNptkN1LwzAUxYMoc04ffRQKgoisNTcfTfIom18wEETBt5C2qXR0bUzWB_97M7eHIT7d3Ht_OSc5CJ0DzgBEfmuWLgNKMpEJyA_QGDjlqSBEHqIxxpikitOPY3QSwjK2mAoyQiPAikkGY3Q9t87bEJq-myZz2w6bU5gmpquSuR8-k1cbXJzYU3RUmzbYs12doPeH-7fZU7p4eXye3S1SQzms08LSuqoMz3GpBAVTEwJgS8wVZ3mRM0VFKUtem8owIykTvOCG1rlV3MRfSDpBV1td5_uvwYa1XjWhtG1rOtsPQUuiQAITEbz8Ay77wXfxbRooRENFqYpUuqVK34fgba2db1bGf2vAepOfjvnFC0QLHfOL_MVOdShWttqjfwOL-5vt3jjX7Dn-K_YD5AR2eQ</recordid><startdate>197507</startdate><enddate>197507</enddate><creator>Glassman, A H</creator><creator>Kantor, S J</creator><creator>Shostak, M</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7X8</scope></search><sort><creationdate>197507</creationdate><title>Depression, Delusions, and Drug Response</title><author>Glassman, A H ; Kantor, S J ; Shostak, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a351t-be3fdda560c9731af2211ec059546b64937c8c5fada4a83475b5a3f6e95a13283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adult</topic><topic>Amitriptyline - 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to tricyclic drug therapy during an ongoing study of depressed patients.
After four weeks of administration of imipramine hydrochloride, only 3 of
13 delusional depressed patients had responded to the drug, but 14 of 21
nondelusional depressed patients had responded. The authors conclude on the
basis of these data and those of other researchers that delusional
depressed patients should not be treated with tricyclic antidepressants and
that current research with depressed patients should be reevaluated in the
light of this finding.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>1094841</pmid><doi>10.1176/ajp.132.7.716</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1975-07, Vol.132 (7), p.716-719 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82918147 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Amitriptyline - therapeutic use Antidepressive Agents, Tricyclic - therapeutic use Clinical Trials as Topic Delusions - complications Delusions - diagnosis Delusions - drug therapy Depression - complications Depression - diagnosis Depression - drug therapy Drug Evaluation Female Humans Imipramine - therapeutic use Male Middle Aged Placebos Psychological Tests Remission, Spontaneous Sex Factors |
| title | Depression, Delusions, and Drug Response |
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