Incorporation of acetylcholinesterase into synaptic vesicles is associated with blockade of synaptic transmission
THE transmission of nerve signals across cholinergic synapses involves the presynaptic release (or secretion) of acetylcholine (ACh) which, by acting on specific sites of the postsynaptic membrane, induces changes in the postsynaptic transmembrane potential. According to the vesicle hypothesis 1 , A...
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| Veröffentlicht in: | Nature (London) 1975-07, Vol.256 (5515), p.324-325 |
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| creator | POLITOFF, ALBERTO BLITZ, ALAN L. ROSE, STEVEN |
| description | THE transmission of nerve signals across cholinergic synapses involves the presynaptic release (or secretion) of acetylcholine (ACh) which, by acting on specific sites of the postsynaptic membrane, induces changes in the postsynaptic transmembrane potential. According to the vesicle hypothesis
1
, ACh is packed inside synaptic vesicles which release their contents from the nerve terminal on contact with the presynaptic membrane. Although there is abundant experimental evidence supporting the hypothesis
2
, some papers question its validity
3–6
. The most important alternative hypothesis postulates that the releasable ACh is free in the cytoplasm
3–6
and that the vesicles are a secondary reservoir containing ‘bound’ ACh. |
| doi_str_mv | 10.1038/256324a0 |
| format | Article |
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1
, ACh is packed inside synaptic vesicles which release their contents from the nerve terminal on contact with the presynaptic membrane. Although there is abundant experimental evidence supporting the hypothesis
2
, some papers question its validity
3–6
. The most important alternative hypothesis postulates that the releasable ACh is free in the cytoplasm
3–6
and that the vesicles are a secondary reservoir containing ‘bound’ ACh.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/256324a0</identifier><identifier>PMID: 167288</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Acetylcholinesterase - metabolism ; Animals ; Anura ; Humanities and Social Sciences ; letter ; Membrane Potentials ; Methods ; multidisciplinary ; Neuromuscular Junction - metabolism ; Neuromuscular Junction - ultrastructure ; Science ; Science (multidisciplinary) ; Synaptic Transmission ; Synaptic Vesicles - metabolism</subject><ispartof>Nature (London), 1975-07, Vol.256 (5515), p.324-325</ispartof><rights>Springer Nature Limited 1975</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-5e1e4ef75475f1bc09c0452afaa513b240a7fbec4f6ea3de35fa5d89684f6c803</citedby><cites>FETCH-LOGICAL-c311t-5e1e4ef75475f1bc09c0452afaa513b240a7fbec4f6ea3de35fa5d89684f6c803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/256324a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/256324a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/167288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>POLITOFF, ALBERTO</creatorcontrib><creatorcontrib>BLITZ, ALAN L.</creatorcontrib><creatorcontrib>ROSE, STEVEN</creatorcontrib><title>Incorporation of acetylcholinesterase into synaptic vesicles is associated with blockade of synaptic transmission</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>THE transmission of nerve signals across cholinergic synapses involves the presynaptic release (or secretion) of acetylcholine (ACh) which, by acting on specific sites of the postsynaptic membrane, induces changes in the postsynaptic transmembrane potential. According to the vesicle hypothesis
1
, ACh is packed inside synaptic vesicles which release their contents from the nerve terminal on contact with the presynaptic membrane. Although there is abundant experimental evidence supporting the hypothesis
2
, some papers question its validity
3–6
. The most important alternative hypothesis postulates that the releasable ACh is free in the cytoplasm
3–6
and that the vesicles are a secondary reservoir containing ‘bound’ ACh.</description><subject>Acetylcholinesterase - metabolism</subject><subject>Animals</subject><subject>Anura</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Membrane Potentials</subject><subject>Methods</subject><subject>multidisciplinary</subject><subject>Neuromuscular Junction - metabolism</subject><subject>Neuromuscular Junction - ultrastructure</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Synaptic Transmission</subject><subject>Synaptic Vesicles - metabolism</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEFPHDEMhaOqlC4UiR_AISdED0OTmWQme6wQUCQkLnAeeTIOGzqbLHG21f57siylB06W_D4_24-xYynOpWjMj1q3Ta1AfGIzqbq2Uq3pPrOZELWphGnar-yA6EkIoWWn9tkX2Xa1MTP2fBNsTKuYIPsYeHQcLObNZBdx8gEpYwJC7kOOnDYBVtlb_gfJ2wmJe-JAFK2HjCP_6_OCD1O0v2HErdX7QE4QaOmJyo5vbM_BRHj0Vg_Zw9Xl_cWv6vbu-ubi521lGylzpVGiQtdp1WknByvmVihdgwPQshlqJaBzA1rlWoRmxEY70KOZt6Z0rBHNITvd-a5SfF6XT_pygMVpgoBxTb2p51Kqel7Asx1oUyRK6PpV8ktIm16Kfhtu_y_cgp68ea6HJY7_wdc0i_x9J1MRwiOm_imuUyhffrR6AWZbhN8</recordid><startdate>19750724</startdate><enddate>19750724</enddate><creator>POLITOFF, ALBERTO</creator><creator>BLITZ, ALAN L.</creator><creator>ROSE, STEVEN</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19750724</creationdate><title>Incorporation of acetylcholinesterase into synaptic vesicles is associated with blockade of synaptic transmission</title><author>POLITOFF, ALBERTO ; BLITZ, ALAN L. ; ROSE, STEVEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-5e1e4ef75475f1bc09c0452afaa513b240a7fbec4f6ea3de35fa5d89684f6c803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Acetylcholinesterase - metabolism</topic><topic>Animals</topic><topic>Anura</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Membrane Potentials</topic><topic>Methods</topic><topic>multidisciplinary</topic><topic>Neuromuscular Junction - metabolism</topic><topic>Neuromuscular Junction - ultrastructure</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Synaptic Transmission</topic><topic>Synaptic Vesicles - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>POLITOFF, ALBERTO</creatorcontrib><creatorcontrib>BLITZ, ALAN L.</creatorcontrib><creatorcontrib>ROSE, STEVEN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>POLITOFF, ALBERTO</au><au>BLITZ, ALAN L.</au><au>ROSE, STEVEN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incorporation of acetylcholinesterase into synaptic vesicles is associated with blockade of synaptic transmission</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1975-07-24</date><risdate>1975</risdate><volume>256</volume><issue>5515</issue><spage>324</spage><epage>325</epage><pages>324-325</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>THE transmission of nerve signals across cholinergic synapses involves the presynaptic release (or secretion) of acetylcholine (ACh) which, by acting on specific sites of the postsynaptic membrane, induces changes in the postsynaptic transmembrane potential. According to the vesicle hypothesis
1
, ACh is packed inside synaptic vesicles which release their contents from the nerve terminal on contact with the presynaptic membrane. Although there is abundant experimental evidence supporting the hypothesis
2
, some papers question its validity
3–6
. The most important alternative hypothesis postulates that the releasable ACh is free in the cytoplasm
3–6
and that the vesicles are a secondary reservoir containing ‘bound’ ACh.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>167288</pmid><doi>10.1038/256324a0</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1975-07, Vol.256 (5515), p.324-325 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Acetylcholinesterase - metabolism Animals Anura Humanities and Social Sciences letter Membrane Potentials Methods multidisciplinary Neuromuscular Junction - metabolism Neuromuscular Junction - ultrastructure Science Science (multidisciplinary) Synaptic Transmission Synaptic Vesicles - metabolism |
| title | Incorporation of acetylcholinesterase into synaptic vesicles is associated with blockade of synaptic transmission |
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