Gallium-67 citrate uptake by cultured tumor cells, stimulated by serum transferrin
The uptake of the tumor scanning agent 67-Ga citrate by cultured mouse tumor cells wqs greatly enhanced with small additons of certain sera to the culture medium. This stimulation of uptake was due to a macromolecular serum component, provisionally identified with transferrin. The response under opt...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1975-05, Vol.54 (5), p.1263-1266 |
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| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 54 |
| creator | Sephton, R G Harris, A W |
| description | The uptake of the tumor scanning agent 67-Ga citrate by cultured mouse tumor cells wqs greatly enhanced with small additons of certain sera to the culture medium. This stimulation of uptake was due to a macromolecular serum component, provisionally identified with transferrin. The response under optimum conditions was so great as to suggest that the 67-Ga uptake process depends entirely on the action of transferrin. The same mechanism probably operates in vivo and may help explain interesting features of the tracer's tissue distribution, particularly its tumor affinity. |
| doi_str_mv | 10.1093/jnci/54.5.1263 |
| format | Article |
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This stimulation of uptake was due to a macromolecular serum component, provisionally identified with transferrin. The response under optimum conditions was so great as to suggest that the 67-Ga uptake process depends entirely on the action of transferrin. 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This stimulation of uptake was due to a macromolecular serum component, provisionally identified with transferrin. The response under optimum conditions was so great as to suggest that the 67-Ga uptake process depends entirely on the action of transferrin. The same mechanism probably operates in vivo and may help explain interesting features of the tracer's tissue distribution, particularly its tumor affinity.</description><subject>Animals</subject><subject>Cell Line</subject><subject>Clone Cells</subject><subject>Gallium - metabolism</subject><subject>Gallium Radioisotopes</subject><subject>Mice</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Stimulation, Chemical</subject><subject>Transferrin - pharmacology</subject><issn>0027-8874</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkD1PwzAYhD2ASimsbEiemEj7Ov7MiBAUpEpICObIcd5IKXEa_DH035OK3nLLc6fTEXLHYM2g4pv96PqNFGu5ZqXiF2QJUOrCGC2uyHWMe5hVlWJBFowpozksyefWDkOffaE0dX0KNiHNU7I_SJsjdXlIOWBLU_aHQB0OQ3ykMfU-DzPZnpiIIXs6J8fYYQj9eEMuOztEvD37iny_vnw9vxW7j-3789OumEpQqeik0KI0pRVCGqi0kkIK5zqpGmuBoeUtgjKtQSeZFEoAN6gardGAU7zhK_Lw3zuFw2_GmGrfx9NEO-Ihx9qUFVTAYAbvz2BuPLb1FHpvw7E-n8D_APktXFw</recordid><startdate>197505</startdate><enddate>197505</enddate><creator>Sephton, R G</creator><creator>Harris, A W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197505</creationdate><title>Gallium-67 citrate uptake by cultured tumor cells, stimulated by serum transferrin</title><author>Sephton, R G ; Harris, A W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p206t-f5474282a445809765454ccf56baa01ea3de068d8ec515464038e6b77e80c63b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Cell Line</topic><topic>Clone Cells</topic><topic>Gallium - metabolism</topic><topic>Gallium Radioisotopes</topic><topic>Mice</topic><topic>Neoplasms, Experimental - metabolism</topic><topic>Stimulation, Chemical</topic><topic>Transferrin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sephton, R G</creatorcontrib><creatorcontrib>Harris, A W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sephton, R G</au><au>Harris, A W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gallium-67 citrate uptake by cultured tumor cells, stimulated by serum transferrin</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>1975-05</date><risdate>1975</risdate><volume>54</volume><issue>5</issue><spage>1263</spage><epage>1266</epage><pages>1263-1266</pages><issn>0027-8874</issn><abstract>The uptake of the tumor scanning agent 67-Ga citrate by cultured mouse tumor cells wqs greatly enhanced with small additons of certain sera to the culture medium. This stimulation of uptake was due to a macromolecular serum component, provisionally identified with transferrin. The response under optimum conditions was so great as to suggest that the 67-Ga uptake process depends entirely on the action of transferrin. The same mechanism probably operates in vivo and may help explain interesting features of the tracer's tissue distribution, particularly its tumor affinity.</abstract><cop>United States</cop><pmid>1168730</pmid><doi>10.1093/jnci/54.5.1263</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1975-05, Vol.54 (5), p.1263-1266 |
| issn | 0027-8874 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82909010 |
| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Animals Cell Line Clone Cells Gallium - metabolism Gallium Radioisotopes Mice Neoplasms, Experimental - metabolism Stimulation, Chemical Transferrin - pharmacology |
| title | Gallium-67 citrate uptake by cultured tumor cells, stimulated by serum transferrin |
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