Genetic Linkage between the HL-A System and a Deficit of the Second Component (C2) of Complement

From a family of 14 individuals, evidence was obtained suggesting linkage between the HL-A haplotypes and the transmission of a 50 percent deficit in the functional activity of the C2 component of complement.

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1975-06, Vol.188 (4192), p.1020-1022
Hauptverfasser: Wolski, Kenneth P., Schmid, Frank R., Mittal, Kamal K.
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container_issue 4192
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container_title Science (American Association for the Advancement of Science)
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creator Wolski, Kenneth P.
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description From a family of 14 individuals, evidence was obtained suggesting linkage between the HL-A haplotypes and the transmission of a 50 percent deficit in the functional activity of the C2 component of complement.
doi_str_mv 10.1126/science.1145185
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source MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy
subjects Adolescent
Adult
Aged
Alleles
Amino acids
Complement C2 - deficiency
Complement System Proteins - deficiency
Evolution
Female
Genetic inheritance
Genetic Linkage
Genetic mutation
Haplotypes
Heterozygote
Histocompatibility Antigens
HLA Antigens
Homozygote
Humans
Male
Middle Aged
Molecules
Pedigree
Siblings
Systemic lupus erythematosus
title Genetic Linkage between the HL-A System and a Deficit of the Second Component (C2) of Complement
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