Microangiopathic hemolytic anemia in renal allotransplantation. Repart of a successfully treated case and review of the literature
The development of microangiopathic hemolytic anemia after renal transplantation in a 17 year old white boy is reported, and the literature is reviewed. In this patient microangiopathic hemolytic anemia developed 6 weeks after renal transplantation during a second episode of rejection. Light, fluore...
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| Veröffentlicht in: | The American journal of medicine 1975-06, Vol.58 (6), p.862-868 |
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| container_issue | 6 |
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| container_title | The American journal of medicine |
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| creator | Magalhaes, R L Braun, W E Straffon, R A Hoffman, G C Shainoff, J R Osborne, G Deodhar, S D |
| description | The development of microangiopathic hemolytic anemia after renal transplantation in a 17 year old white boy is reported, and the literature is reviewed. In this patient microangiopathic hemolytic anemia developed 6 weeks after renal transplantation during a second episode of rejection. Light, fluorescence and electron microscopy demonstrated the renal vascular lesion associated with this syndrome. In contrast to the other four previously reported cases of microangiopathic hemolytic anemia associated with renal allotransplantation, this patient had complete resolution of the microangiopathic hemolytic anemia with heparin therapy and improved allograft function, presumably with diminution of the vascular lesion. He survived a complicated early period after renal transplantation and has shown no recurrence of microangiopathic hemolytic anemia in the 18 months since transplantation. Special red blood cell and fibrinogen studies are discussed. |
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In contrast to the other four previously reported cases of microangiopathic hemolytic anemia associated with renal allotransplantation, this patient had complete resolution of the microangiopathic hemolytic anemia with heparin therapy and improved allograft function, presumably with diminution of the vascular lesion. He survived a complicated early period after renal transplantation and has shown no recurrence of microangiopathic hemolytic anemia in the 18 months since transplantation. Special red blood cell and fibrinogen studies are discussed.</description><identifier>ISSN: 0002-9343</identifier><identifier>PMID: 1094830</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Creatinine - blood ; Erythrocyte Aging ; Fibrinogen - analysis ; Fluorescent Antibody Technique ; Glomerulonephritis - surgery ; Graft Rejection ; Hemoglobins - analysis ; Heparin - therapeutic use ; Humans ; Kidney - pathology ; Kidney Glomerulus - ultrastructure ; Kidney Neoplasms - complications ; Kidney Transplantation ; Lymphangioma - complications ; Male ; Microscopy, Electron ; Microscopy, Fluorescence ; Purpura, Thrombotic Thrombocytopenic - drug therapy ; Purpura, Thrombotic Thrombocytopenic - etiology ; Purpura, Thrombotic Thrombocytopenic - pathology ; Transplantation, Homologous</subject><ispartof>The American journal of medicine, 1975-06, Vol.58 (6), p.862-868</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1094830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magalhaes, R L</creatorcontrib><creatorcontrib>Braun, W E</creatorcontrib><creatorcontrib>Straffon, R A</creatorcontrib><creatorcontrib>Hoffman, G C</creatorcontrib><creatorcontrib>Shainoff, J R</creatorcontrib><creatorcontrib>Osborne, G</creatorcontrib><creatorcontrib>Deodhar, S D</creatorcontrib><title>Microangiopathic hemolytic anemia in renal allotransplantation. Repart of a successfully treated case and review of the literature</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>The development of microangiopathic hemolytic anemia after renal transplantation in a 17 year old white boy is reported, and the literature is reviewed. In this patient microangiopathic hemolytic anemia developed 6 weeks after renal transplantation during a second episode of rejection. Light, fluorescence and electron microscopy demonstrated the renal vascular lesion associated with this syndrome. In contrast to the other four previously reported cases of microangiopathic hemolytic anemia associated with renal allotransplantation, this patient had complete resolution of the microangiopathic hemolytic anemia with heparin therapy and improved allograft function, presumably with diminution of the vascular lesion. He survived a complicated early period after renal transplantation and has shown no recurrence of microangiopathic hemolytic anemia in the 18 months since transplantation. Special red blood cell and fibrinogen studies are discussed.</description><subject>Adolescent</subject><subject>Creatinine - blood</subject><subject>Erythrocyte Aging</subject><subject>Fibrinogen - analysis</subject><subject>Fluorescent Antibody Technique</subject><subject>Glomerulonephritis - surgery</subject><subject>Graft Rejection</subject><subject>Hemoglobins - analysis</subject><subject>Heparin - therapeutic use</subject><subject>Humans</subject><subject>Kidney - pathology</subject><subject>Kidney Glomerulus - ultrastructure</subject><subject>Kidney Neoplasms - complications</subject><subject>Kidney Transplantation</subject><subject>Lymphangioma - complications</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Microscopy, Fluorescence</subject><subject>Purpura, Thrombotic Thrombocytopenic - drug therapy</subject><subject>Purpura, Thrombotic Thrombocytopenic - etiology</subject><subject>Purpura, Thrombotic Thrombocytopenic - pathology</subject><subject>Transplantation, Homologous</subject><issn>0002-9343</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkE1LxDAQhntQ1nX1Jwg5eaukTZNtjrL4sbAiyN7LNJ24kTSpSars1V9uxD3NDDw8zPueFUtKaV1K1rCL4jLGj3xSycWiWFRUNi2jy-Lnxajgwb0bP0E6GEUOOHp7THkDh6MBYhwJ6MASsNanAC5OFlyCZLy7I284QUjEawIkzkphjHq29khSQEg4EAURs2rIki-D339kOiCxJmGANAe8Ks412IjXp7kq9o8P-81zuXt92m7ud-XEGS3b_PCgBWM5QLMeWtFUCFr0sO4FR5CCaqV7LgXj2Pca1lVba841p3WlVINsVdz-a6fgP2eMqRtNVGhzFvRz7Nq6bSUVMoM3J3DuRxy6KZgRwrE7dcZ-AZaqams</recordid><startdate>197506</startdate><enddate>197506</enddate><creator>Magalhaes, R L</creator><creator>Braun, W E</creator><creator>Straffon, R A</creator><creator>Hoffman, G C</creator><creator>Shainoff, J R</creator><creator>Osborne, G</creator><creator>Deodhar, S D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197506</creationdate><title>Microangiopathic hemolytic anemia in renal allotransplantation. Repart of a successfully treated case and review of the literature</title><author>Magalhaes, R L ; Braun, W E ; Straffon, R A ; Hoffman, G C ; Shainoff, J R ; Osborne, G ; Deodhar, S D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p530-8948df63395647d8641eaf6ba7b65ea960fcfb59635ebbfa7182f55f5021cc4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adolescent</topic><topic>Creatinine - blood</topic><topic>Erythrocyte Aging</topic><topic>Fibrinogen - analysis</topic><topic>Fluorescent Antibody Technique</topic><topic>Glomerulonephritis - surgery</topic><topic>Graft Rejection</topic><topic>Hemoglobins - analysis</topic><topic>Heparin - therapeutic use</topic><topic>Humans</topic><topic>Kidney - pathology</topic><topic>Kidney Glomerulus - ultrastructure</topic><topic>Kidney Neoplasms - complications</topic><topic>Kidney Transplantation</topic><topic>Lymphangioma - complications</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Microscopy, Fluorescence</topic><topic>Purpura, Thrombotic Thrombocytopenic - drug therapy</topic><topic>Purpura, Thrombotic Thrombocytopenic - etiology</topic><topic>Purpura, Thrombotic Thrombocytopenic - pathology</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magalhaes, R L</creatorcontrib><creatorcontrib>Braun, W E</creatorcontrib><creatorcontrib>Straffon, R A</creatorcontrib><creatorcontrib>Hoffman, G C</creatorcontrib><creatorcontrib>Shainoff, J R</creatorcontrib><creatorcontrib>Osborne, G</creatorcontrib><creatorcontrib>Deodhar, S D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magalhaes, R L</au><au>Braun, W E</au><au>Straffon, R A</au><au>Hoffman, G C</au><au>Shainoff, J R</au><au>Osborne, G</au><au>Deodhar, S D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microangiopathic hemolytic anemia in renal allotransplantation. Repart of a successfully treated case and review of the literature</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1975-06</date><risdate>1975</risdate><volume>58</volume><issue>6</issue><spage>862</spage><epage>868</epage><pages>862-868</pages><issn>0002-9343</issn><abstract>The development of microangiopathic hemolytic anemia after renal transplantation in a 17 year old white boy is reported, and the literature is reviewed. In this patient microangiopathic hemolytic anemia developed 6 weeks after renal transplantation during a second episode of rejection. Light, fluorescence and electron microscopy demonstrated the renal vascular lesion associated with this syndrome. In contrast to the other four previously reported cases of microangiopathic hemolytic anemia associated with renal allotransplantation, this patient had complete resolution of the microangiopathic hemolytic anemia with heparin therapy and improved allograft function, presumably with diminution of the vascular lesion. He survived a complicated early period after renal transplantation and has shown no recurrence of microangiopathic hemolytic anemia in the 18 months since transplantation. Special red blood cell and fibrinogen studies are discussed.</abstract><cop>United States</cop><pmid>1094830</pmid><tpages>7</tpages></addata></record> |
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| ispartof | The American journal of medicine, 1975-06, Vol.58 (6), p.862-868 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Creatinine - blood Erythrocyte Aging Fibrinogen - analysis Fluorescent Antibody Technique Glomerulonephritis - surgery Graft Rejection Hemoglobins - analysis Heparin - therapeutic use Humans Kidney - pathology Kidney Glomerulus - ultrastructure Kidney Neoplasms - complications Kidney Transplantation Lymphangioma - complications Male Microscopy, Electron Microscopy, Fluorescence Purpura, Thrombotic Thrombocytopenic - drug therapy Purpura, Thrombotic Thrombocytopenic - etiology Purpura, Thrombotic Thrombocytopenic - pathology Transplantation, Homologous |
| title | Microangiopathic hemolytic anemia in renal allotransplantation. Repart of a successfully treated case and review of the literature |
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