Factitious Changes in Binding of Oxygen to Hemoglobin When Based on Extracellular pH in the Presence of Certain Blood Additives Like Radiographic Contrast Media
Construction of oxygen-hemoglobin dissociation curves based on extracellular pH and using blood tonometered with 5% CO2, is misleading under certain experimental conditions. These include the presence in blood of poorly penetrating non-ionic molecules like sucrose or poorly penetrating anionic compo...
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| Veröffentlicht in: | Invest. Radiol.; (United States) 1975-05, Vol.10 (3), p.225-230 |
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| container_title | Invest. Radiol.; (United States) |
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| creator | Lichtman, Marshall A Whitbeck, April A Murphy, Marion |
| description | Construction of oxygen-hemoglobin dissociation curves based on extracellular pH and using blood tonometered with 5% CO2, is misleading under certain experimental conditions. These include the presence in blood of poorly penetrating non-ionic molecules like sucrose or poorly penetrating anionic compounds like radiographic contrast materials. False conclusions regarding the position of the oxygen-hemoglobin dissociation curve can result because of the disturbance of the normal pH gradient between plasma and red cell induced by such chemicals. |
| doi_str_mv | 10.1097/00004424-197505000-00006 |
| format | Article |
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These include the presence in blood of poorly penetrating non-ionic molecules like sucrose or poorly penetrating anionic compounds like radiographic contrast materials. False conclusions regarding the position of the oxygen-hemoglobin dissociation curve can result because of the disturbance of the normal pH gradient between plasma and red cell induced by such chemicals.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-197505000-00006</identifier><identifier>PMID: 236989</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>550200 - Biochemistry ; 551000 - Physiological Systems ; BASIC BIOLOGICAL SCIENCES ; BIOCHEMICAL REACTION KINETICS ; BIOLOGICAL MATERIALS ; BIOMEDICAL RADIOGRAPHY ; BLOOD ; BLOOD CELLS ; BODY FLUIDS ; CARBOXYLIC ACIDS ; COMPLEXES ; CONTRAST MEDIA ; CRYOGENIC FLUIDS ; DIAGNOSTIC TECHNIQUES ; Diatrizoate ; ELEMENTS ; ERYTHROCYTES ; FLUIDS ; GLOBIN ; HEMOGLOBIN ; Hemoglobins ; HETEROCYCLIC ACIDS ; HETEROCYCLIC COMPOUNDS ; Humans ; Hydrogen-Ion Concentration ; KINETICS ; MEDICINE ; NONMETALS ; NUCLEAR MEDICINE ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; OXYGEN ; Oxygen - blood ; OXYGEN COMPLEXES ; PH VALUE ; PIGMENTS ; PORPHYRINS ; Protein Binding ; PROTEINS ; RADIOLOGY ; REACTION KINETICS ; Sucrose ; Veins</subject><ispartof>Invest. 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Radiol.; (United States)</title><addtitle>Invest Radiol</addtitle><description>Construction of oxygen-hemoglobin dissociation curves based on extracellular pH and using blood tonometered with 5% CO2, is misleading under certain experimental conditions. These include the presence in blood of poorly penetrating non-ionic molecules like sucrose or poorly penetrating anionic compounds like radiographic contrast materials. False conclusions regarding the position of the oxygen-hemoglobin dissociation curve can result because of the disturbance of the normal pH gradient between plasma and red cell induced by such chemicals.</description><subject>550200 - Biochemistry</subject><subject>551000 - Physiological Systems</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BIOCHEMICAL REACTION KINETICS</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BIOMEDICAL RADIOGRAPHY</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>BODY FLUIDS</subject><subject>CARBOXYLIC ACIDS</subject><subject>COMPLEXES</subject><subject>CONTRAST MEDIA</subject><subject>CRYOGENIC FLUIDS</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>Diatrizoate</subject><subject>ELEMENTS</subject><subject>ERYTHROCYTES</subject><subject>FLUIDS</subject><subject>GLOBIN</subject><subject>HEMOGLOBIN</subject><subject>Hemoglobins</subject><subject>HETEROCYCLIC ACIDS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>KINETICS</subject><subject>MEDICINE</subject><subject>NONMETALS</subject><subject>NUCLEAR MEDICINE</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>OXYGEN</subject><subject>Oxygen - blood</subject><subject>OXYGEN COMPLEXES</subject><subject>PH VALUE</subject><subject>PIGMENTS</subject><subject>PORPHYRINS</subject><subject>Protein Binding</subject><subject>PROTEINS</subject><subject>RADIOLOGY</subject><subject>REACTION KINETICS</subject><subject>Sucrose</subject><subject>Veins</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1Uk1v1DAUtBBfy8I_4GBx4BawndhJjm3UskiLihCIo-XYLxvTrL3YDm3_DT8Vh5Te8OXJ8-bNyG-MEKbkHSVt_Z7kU1WsKmhbc8LzrVgg8QhtKC9FQRglj9GGEEaKtm3Fc_Qixh-ZwWpSPkNPWSnapt2g35dKJ5usnyPuRuUOELF1-Nw6Y90B-wFf3d4dwOHk8Q6O_jD5Pve_jxk6VxEM9g5f3KagNEzTPKmAT7tFIY2APweI4DQsMh2EpBblyXuDz4zJpr-y2d5eA_6ijPWHoE6j1bjzLsvFhD-BseolejKoKcKr-7pF3y4vvna7Yn_14WN3ti902VBRDJyVnLFeDa2AoV7K0FOhmAYghgutDdWV4EYM3LS06aGmwIE2vNaclnW5RW9WXR-TlVHbBHrU3jnQSeb9cpYdtujtSjoF_3OGmOTRxuXhykHeoGxY03DalJnYrEQdfIwBBnkK9qjCnaRELgHKfwHKhwD_QiKPvr73mPsjmIfBNbHcrtb2jZ8ShHg9zTcQ5AhqSqP837co_wBvWKbR</recordid><startdate>197505</startdate><enddate>197505</enddate><creator>Lichtman, Marshall A</creator><creator>Whitbeck, April A</creator><creator>Murphy, Marion</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>197505</creationdate><title>Factitious Changes in Binding of Oxygen to Hemoglobin When Based on Extracellular pH in the Presence of Certain Blood Additives Like Radiographic Contrast Media</title><author>Lichtman, Marshall A ; Whitbeck, April A ; Murphy, Marion</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3816-f523522baf96ef7af96fb16a2cee0d56ccd1c465d6f5d918be71e5e1857c51373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>550200 - Biochemistry</topic><topic>551000 - Physiological Systems</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BIOCHEMICAL REACTION KINETICS</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BIOMEDICAL RADIOGRAPHY</topic><topic>BLOOD</topic><topic>BLOOD CELLS</topic><topic>BODY FLUIDS</topic><topic>CARBOXYLIC ACIDS</topic><topic>COMPLEXES</topic><topic>CONTRAST MEDIA</topic><topic>CRYOGENIC FLUIDS</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>Diatrizoate</topic><topic>ELEMENTS</topic><topic>ERYTHROCYTES</topic><topic>FLUIDS</topic><topic>GLOBIN</topic><topic>HEMOGLOBIN</topic><topic>Hemoglobins</topic><topic>HETEROCYCLIC ACIDS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>KINETICS</topic><topic>MEDICINE</topic><topic>NONMETALS</topic><topic>NUCLEAR MEDICINE</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>OXYGEN</topic><topic>Oxygen - blood</topic><topic>OXYGEN COMPLEXES</topic><topic>PH VALUE</topic><topic>PIGMENTS</topic><topic>PORPHYRINS</topic><topic>Protein Binding</topic><topic>PROTEINS</topic><topic>RADIOLOGY</topic><topic>REACTION KINETICS</topic><topic>Sucrose</topic><topic>Veins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lichtman, Marshall A</creatorcontrib><creatorcontrib>Whitbeck, April A</creatorcontrib><creatorcontrib>Murphy, Marion</creatorcontrib><creatorcontrib>Univ. of Rochester, NY</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Invest. Radiol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lichtman, Marshall A</au><au>Whitbeck, April A</au><au>Murphy, Marion</au><aucorp>Univ. of Rochester, NY</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factitious Changes in Binding of Oxygen to Hemoglobin When Based on Extracellular pH in the Presence of Certain Blood Additives Like Radiographic Contrast Media</atitle><jtitle>Invest. Radiol.; (United States)</jtitle><addtitle>Invest Radiol</addtitle><date>1975-05</date><risdate>1975</risdate><volume>10</volume><issue>3</issue><spage>225</spage><epage>230</epage><pages>225-230</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>Construction of oxygen-hemoglobin dissociation curves based on extracellular pH and using blood tonometered with 5% CO2, is misleading under certain experimental conditions. These include the presence in blood of poorly penetrating non-ionic molecules like sucrose or poorly penetrating anionic compounds like radiographic contrast materials. False conclusions regarding the position of the oxygen-hemoglobin dissociation curve can result because of the disturbance of the normal pH gradient between plasma and red cell induced by such chemicals.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>236989</pmid><doi>10.1097/00004424-197505000-00006</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0020-9996 |
| ispartof | Invest. Radiol.; (United States), 1975-05, Vol.10 (3), p.225-230 |
| issn | 0020-9996 1536-0210 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | 550200 - Biochemistry 551000 - Physiological Systems BASIC BIOLOGICAL SCIENCES BIOCHEMICAL REACTION KINETICS BIOLOGICAL MATERIALS BIOMEDICAL RADIOGRAPHY BLOOD BLOOD CELLS BODY FLUIDS CARBOXYLIC ACIDS COMPLEXES CONTRAST MEDIA CRYOGENIC FLUIDS DIAGNOSTIC TECHNIQUES Diatrizoate ELEMENTS ERYTHROCYTES FLUIDS GLOBIN HEMOGLOBIN Hemoglobins HETEROCYCLIC ACIDS HETEROCYCLIC COMPOUNDS Humans Hydrogen-Ion Concentration KINETICS MEDICINE NONMETALS NUCLEAR MEDICINE ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS OXYGEN Oxygen - blood OXYGEN COMPLEXES PH VALUE PIGMENTS PORPHYRINS Protein Binding PROTEINS RADIOLOGY REACTION KINETICS Sucrose Veins |
| title | Factitious Changes in Binding of Oxygen to Hemoglobin When Based on Extracellular pH in the Presence of Certain Blood Additives Like Radiographic Contrast Media |
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