A reproducible gas chromatographic mass spectrometric assay for low levels of methylphenidate and ritalinic acid in blood and urine
A rapid, sensitive method of analysis for methylphenidate and ritalinic acid in blood and urine has been developed using gas chromatography mass spectrometry and selected ion monitoring for separation and detection. The methylphenidate is isolated by solvent extraction into chloroform and the ritali...
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| Veröffentlicht in: | Biological Mass Spectrometry 1975-02, Vol.2 (1), p.2-8 |
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| container_title | Biological Mass Spectrometry |
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| creator | Milberg, R. M. Rinehart Jr, K. L. Sprague, R. L. Sleator, E. K. |
| description | A rapid, sensitive method of analysis for methylphenidate and ritalinic acid in blood and urine has been developed using gas chromatography mass spectrometry and selected ion monitoring for separation and detection. The methylphenidate is isolated by solvent extraction into chloroform and the ritalinic acid is isolated by salting out into isopropyl alcohol, followed by methylation and subsequent solvent extraction. The method has been applied to the study of methylphenidate metabolism and excretion in adults and hyperactive children under‐going treatment with methylphenidate. |
| doi_str_mv | 10.1002/bms.1200020103 |
| format | Article |
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L.</creatorcontrib><creatorcontrib>Sleator, E. K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological Mass Spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Milberg, R. M.</au><au>Rinehart Jr, K. L.</au><au>Sprague, R. L.</au><au>Sleator, E. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A reproducible gas chromatographic mass spectrometric assay for low levels of methylphenidate and ritalinic acid in blood and urine</atitle><jtitle>Biological Mass Spectrometry</jtitle><addtitle>Biol. Mass Spectrom</addtitle><date>1975-02</date><risdate>1975</risdate><volume>2</volume><issue>1</issue><spage>2</spage><epage>8</epage><pages>2-8</pages><issn>1052-9306</issn><issn>0306-042X</issn><eissn>1096-9888</eissn><abstract>A rapid, sensitive method of analysis for methylphenidate and ritalinic acid in blood and urine has been developed using gas chromatography mass spectrometry and selected ion monitoring for separation and detection. The methylphenidate is isolated by solvent extraction into chloroform and the ritalinic acid is isolated by salting out into isopropyl alcohol, followed by methylation and subsequent solvent extraction. The method has been applied to the study of methylphenidate metabolism and excretion in adults and hyperactive children under‐going treatment with methylphenidate.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>1131389</pmid><doi>10.1002/bms.1200020103</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1052-9306 |
| ispartof | Biological Mass Spectrometry, 1975-02, Vol.2 (1), p.2-8 |
| issn | 1052-9306 0306-042X 1096-9888 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82865035 |
| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Adult Child Chromatography, Gas - methods Female Humans Hyperkinesis - blood Hyperkinesis - drug therapy Hyperkinesis - urine Male Mass Spectrometry - methods Methylphenidate - analogs & derivatives Methylphenidate - analysis Methylphenidate - blood Methylphenidate - therapeutic use Methylphenidate - urine |
| title | A reproducible gas chromatographic mass spectrometric assay for low levels of methylphenidate and ritalinic acid in blood and urine |
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