INFLUENCE OF TREATMENT WITH DIET ALONE ON ORAL GLUCOSE-TOLERANCE TEST AND PLASMA SUGAR AND INSULIN LEVELS IN PATIENTS WITH MATURITY-ONSET DIABETES MELLITUS
Oral glucose-tolerance test (O.G.T.T.) plasma sugar and insulin levels were measured in 118 newly diagnosed maturity-onset diabetic patients before and after treatment with diet alone for periods of 2 and 6 months. The results of glucose-tolerance tests carried out during treatment could be predicte...
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| Veröffentlicht in: | The Lancet (British edition) 1975-06, Vol.305 (7919), p.1263-1266 |
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| creator | Doar, J.W.H. Wilde, C.E. Thompson, M.E. Sewell, P.F.J. |
| description | Oral glucose-tolerance test (O.G.T.T.) plasma sugar and insulin levels were measured in 118 newly diagnosed maturity-onset diabetic patients before and after treatment with diet alone for periods of 2 and 6 months. The results of glucose-tolerance tests carried out during treatment could be predicted from the initial test and the weight reduction between the tests. This prediction was not improved by the addition of further variables, including age, obesity, and plasma-insulin levels during the first test. The change in O.G.T.T. plasma-insulin between the first and second tests was predicted by the result of the initial test, the improvement of glucose tolerance between the two tests, and the degree of weight reduction. 95 % of the group achieved some improvement of glucose tolerance after 2 months of dietary treatment, and 59% of the group achieved adequate diabetic control by this time. It is concluded that treatment with diet alone should be the first-line management for patients with newly diagnosed maturity-onset diabetes mellitus. |
| doi_str_mv | 10.1016/S0140-6736(75)92550-7 |
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The results of glucose-tolerance tests carried out during treatment could be predicted from the initial test and the weight reduction between the tests. This prediction was not improved by the addition of further variables, including age, obesity, and plasma-insulin levels during the first test. The change in O.G.T.T. plasma-insulin between the first and second tests was predicted by the result of the initial test, the improvement of glucose tolerance between the two tests, and the degree of weight reduction. 95 % of the group achieved some improvement of glucose tolerance after 2 months of dietary treatment, and 59% of the group achieved adequate diabetic control by this time. It is concluded that treatment with diet alone should be the first-line management for patients with newly diagnosed maturity-onset diabetes mellitus.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(75)92550-7</identifier><identifier>PMID: 48896</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Age Factors ; Aged ; Blood Glucose - analysis ; Body Weight ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - blood ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - diet therapy ; Diet ; Diet, Diabetic ; Glucose ; Glucose tolerance ; Glucose Tolerance Test ; Humans ; Insulin ; Insulin - blood ; Maturity ; Middle Aged ; Patients ; Plasma ; Predictions ; Remission, Spontaneous ; Sugar ; Time Factors ; Weight reduction</subject><ispartof>The Lancet (British edition), 1975-06, Vol.305 (7919), p.1263-1266</ispartof><rights>1975</rights><rights>Copyright Elsevier Limited Jun 7, 1975</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-44ff063b40afd246375b2de866d4c18a07f4417b2bcde75261a423c8e7059063</citedby><cites>FETCH-LOGICAL-c386t-44ff063b40afd246375b2de866d4c18a07f4417b2bcde75261a423c8e7059063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0140-6736(75)92550-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/48896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doar, J.W.H.</creatorcontrib><creatorcontrib>Wilde, C.E.</creatorcontrib><creatorcontrib>Thompson, M.E.</creatorcontrib><creatorcontrib>Sewell, P.F.J.</creatorcontrib><title>INFLUENCE OF TREATMENT WITH DIET ALONE ON ORAL GLUCOSE-TOLERANCE TEST AND PLASMA SUGAR AND INSULIN LEVELS IN PATIENTS WITH MATURITY-ONSET DIABETES MELLITUS</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Oral glucose-tolerance test (O.G.T.T.) plasma sugar and insulin levels were measured in 118 newly diagnosed maturity-onset diabetic patients before and after treatment with diet alone for periods of 2 and 6 months. 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It is concluded that treatment with diet alone should be the first-line management for patients with newly diagnosed maturity-onset diabetes mellitus.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Blood Glucose - analysis</subject><subject>Body Weight</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diabetes Mellitus - diet therapy</subject><subject>Diet</subject><subject>Diet, Diabetic</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Maturity</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Plasma</subject><subject>Predictions</subject><subject>Remission, Spontaneous</subject><subject>Sugar</subject><subject>Time Factors</subject><subject>Weight reduction</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO0zAYRi3ECMrAEyAkS0gIFgHb8SVdIdO6nUhuMoodLisrF0fKqG2GpEXiWXhZ3HY0CzasLPs_37HlD4A3GH3ECPNPBmGKIi5i_l6wD3PCGIrEEzDDVNCIUfH9KZg9Is_Bi2m6QwhRjtgzcEWTZM5n4E-arXSpsoWC-QraQkm7UZmF31J7A5epslDqPAvDDOaF1HCty0VuVGRzrQp5illlApQt4a2WZiOhKdeyOB-kmSl1mkGtviptwhbeSpsGu7noN9KWRWp_RHlmwkXLVH5RwQY3SuvUluYluOqq7eRfPazXwK6UXdxEOl-nC6mjJk74IaK06xCPa4qqriWUx4LVpPUJ5y1tcFIh0VGKRU3qpvWCEY4rSuIm8QKxeQheg3cX7f04_Dz66eB2_dT47bba--E4uYQknGDCAvj2H_BuOI778DRHCJozQuhcBIpdqGYcpmn0nbsf-101_nYYuVNv7tybO5XiBHPn3twp9_rBfqx3vn1MnYsK08-XqQ8f8av3o5ua3u8b3_ajbw6uHfr_-P8CZqmZ3Q</recordid><startdate>19750607</startdate><enddate>19750607</enddate><creator>Doar, J.W.H.</creator><creator>Wilde, C.E.</creator><creator>Thompson, M.E.</creator><creator>Sewell, P.F.J.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19750607</creationdate><title>INFLUENCE OF TREATMENT WITH DIET ALONE ON ORAL GLUCOSE-TOLERANCE TEST AND PLASMA SUGAR AND INSULIN LEVELS IN PATIENTS WITH MATURITY-ONSET DIABETES MELLITUS</title><author>Doar, J.W.H. ; 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The results of glucose-tolerance tests carried out during treatment could be predicted from the initial test and the weight reduction between the tests. This prediction was not improved by the addition of further variables, including age, obesity, and plasma-insulin levels during the first test. The change in O.G.T.T. plasma-insulin between the first and second tests was predicted by the result of the initial test, the improvement of glucose tolerance between the two tests, and the degree of weight reduction. 95 % of the group achieved some improvement of glucose tolerance after 2 months of dietary treatment, and 59% of the group achieved adequate diabetic control by this time. It is concluded that treatment with diet alone should be the first-line management for patients with newly diagnosed maturity-onset diabetes mellitus.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>48896</pmid><doi>10.1016/S0140-6736(75)92550-7</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 1975-06, Vol.305 (7919), p.1263-1266 |
| issn | 0140-6736 1474-547X |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Age Factors Aged Blood Glucose - analysis Body Weight Diabetes Diabetes mellitus Diabetes Mellitus - blood Diabetes Mellitus - diagnosis Diabetes Mellitus - diet therapy Diet Diet, Diabetic Glucose Glucose tolerance Glucose Tolerance Test Humans Insulin Insulin - blood Maturity Middle Aged Patients Plasma Predictions Remission, Spontaneous Sugar Time Factors Weight reduction |
| title | INFLUENCE OF TREATMENT WITH DIET ALONE ON ORAL GLUCOSE-TOLERANCE TEST AND PLASMA SUGAR AND INSULIN LEVELS IN PATIENTS WITH MATURITY-ONSET DIABETES MELLITUS |
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