Antiviral quinolinehydrazones. Modified Free-Wilson analysis

Eighty-four 4-quinolinehydrazones were synthesized and tested for antiviral activity. Thirty nine derivatives were active against influenza A2 and/or Coxsackie B1 in mice at a dose of 25 mg/kg sc. Structure-activity relationships of 44 derivatives (21 inactive) were analyzed qualitatively using a mo...

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Veröffentlicht in:	Journal of medicinal chemistry 1975-03, Vol.18 (3), p.245-250
Hauptverfasser:	Thomas, Jean, Berkoff, Charles E, Flagg, Walter B, Gallo, John J, Haff, Richard F, Pinto, Carl A, Pellerano, Cesare, Savini, Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - chemical synthesis Antiviral Agents - therapeutic use Coxsackievirus Infections - drug therapy Herpes Simplex - drug therapy Hydrazones - chemical synthesis Hydrazones - therapeutic use Kinetics Mice Orthomyxoviridae Infections - drug therapy Quinolines - chemical synthesis Quinolines - therapeutic use Structure-Activity Relationship
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