Role of the Collecting Duct in the Regulation of Sodium Balance
A large body of evidence has accumulated which demonstrates that sodium transport in some distal nephron segment is altered in response to changes in extracellular fluid volume. Sodium reabsorption in the loop of Henle and distal tubule is directly related to delivery rate and is not inhibited by vo...
Gespeichert in:
| Veröffentlicht in: | Circulation research 1975-06, Vol.36 (6 Suppl 1), p.I-119-I-124 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | I-124 |
|---|---|
| container_issue | 6 Suppl 1 |
| container_start_page | I-119 |
| container_title | Circulation research |
| container_volume | 36 |
| creator | Stein, Jay H Kirschenbaum, Michael A Bay, William H Osgood, Richard W Ferris, Thomas F |
| description | A large body of evidence has accumulated which demonstrates that sodium transport in some distal nephron segment is altered in response to changes in extracellular fluid volume. Sodium reabsorption in the loop of Henle and distal tubule is directly related to delivery rate and is not inhibited by volume expansion. In contrast, recent studies have shown that Ringer loading causes a greater natriuretic response than hyperoncotic albumin because of diminished collecting duct sodium transport in the former model. Additional studies in animals with different basal extracellular fluid volumes and in DOCA-escape rats indicate further that the collecting duct is an important regulator of sodium balance. Although the factors that modulate sodium transport in the collecting duct are not clear, it is postulated that the local release of prostaglandins may be of major importance. |
| doi_str_mv | 10.1161/01.res.36.6.119 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_82856729</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>82856729</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3736-27cb24b9be24f15828082264eae6c4c0aacefda828e985de9fc7e1f2fbb89d053</originalsourceid><addsrcrecordid>eNpNkMtLxDAQxoMouj7OnoSevHWdSdq0OYmuTxCEVc8hTae71exmbVrE_97s4-Bp4Pc9GD7GzhHGiBKvAMcdhbGQYxmB2mMjzHmWZnmB-2wEACothIAjdhzCJwBmgqtDdoigRJHjiF1PvaPEN0k_p2TinSPbt8tZcjfYPmmXGzyl2eBM3_rl2vjm63ZYJLfGmaWlU3bQGBfobHdP2MfD_fvkKX15fXye3LykVhRCprywFc8qVRHPGsxLXkLJuczIkLSZBWMsNbWJnFSZ16QaWxA2vKmqUtWQixN2ue1ddf57oNDrRRssufgE-SHomMxlwVU0Xm2NtvMhdNToVdcuTPerEfR6Mg2op_dvWkgtI1gnLnbVQ7Wg-p9_s1HUs63-411PXfhyww91ek7G9XMdJwYByFNURQ4yTpxGglL8AZwpdgo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>82856729</pqid></control><display><type>article</type><title>Role of the Collecting Duct in the Regulation of Sodium Balance</title><source>MEDLINE</source><source>American Heart Association</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Stein, Jay H ; Kirschenbaum, Michael A ; Bay, William H ; Osgood, Richard W ; Ferris, Thomas F</creator><creatorcontrib>Stein, Jay H ; Kirschenbaum, Michael A ; Bay, William H ; Osgood, Richard W ; Ferris, Thomas F</creatorcontrib><description>A large body of evidence has accumulated which demonstrates that sodium transport in some distal nephron segment is altered in response to changes in extracellular fluid volume. Sodium reabsorption in the loop of Henle and distal tubule is directly related to delivery rate and is not inhibited by volume expansion. In contrast, recent studies have shown that Ringer loading causes a greater natriuretic response than hyperoncotic albumin because of diminished collecting duct sodium transport in the former model. Additional studies in animals with different basal extracellular fluid volumes and in DOCA-escape rats indicate further that the collecting duct is an important regulator of sodium balance. Although the factors that modulate sodium transport in the collecting duct are not clear, it is postulated that the local release of prostaglandins may be of major importance.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.res.36.6.119</identifier><identifier>PMID: 1093751</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Albumins - pharmacology ; Biological Transport ; Blood Pressure ; Desoxycorticosterone - pharmacology ; Diet, Sodium-Restricted ; Extracellular Space - metabolism ; Glomerular Filtration Rate ; Kidney Tubules - physiology ; Kidney Tubules, Distal - physiology ; Kidney Tubules, Proximal - drug effects ; Loop of Henle - physiology ; Natriuresis ; Perfusion ; Prostaglandins - pharmacology ; Sodium - metabolism ; Water-Electrolyte Balance</subject><ispartof>Circulation research, 1975-06, Vol.36 (6 Suppl 1), p.I-119-I-124</ispartof><rights>1975 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3736-27cb24b9be24f15828082264eae6c4c0aacefda828e985de9fc7e1f2fbb89d053</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1093751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stein, Jay H</creatorcontrib><creatorcontrib>Kirschenbaum, Michael A</creatorcontrib><creatorcontrib>Bay, William H</creatorcontrib><creatorcontrib>Osgood, Richard W</creatorcontrib><creatorcontrib>Ferris, Thomas F</creatorcontrib><title>Role of the Collecting Duct in the Regulation of Sodium Balance</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>A large body of evidence has accumulated which demonstrates that sodium transport in some distal nephron segment is altered in response to changes in extracellular fluid volume. Sodium reabsorption in the loop of Henle and distal tubule is directly related to delivery rate and is not inhibited by volume expansion. In contrast, recent studies have shown that Ringer loading causes a greater natriuretic response than hyperoncotic albumin because of diminished collecting duct sodium transport in the former model. Additional studies in animals with different basal extracellular fluid volumes and in DOCA-escape rats indicate further that the collecting duct is an important regulator of sodium balance. Although the factors that modulate sodium transport in the collecting duct are not clear, it is postulated that the local release of prostaglandins may be of major importance.</description><subject>Albumins - pharmacology</subject><subject>Biological Transport</subject><subject>Blood Pressure</subject><subject>Desoxycorticosterone - pharmacology</subject><subject>Diet, Sodium-Restricted</subject><subject>Extracellular Space - metabolism</subject><subject>Glomerular Filtration Rate</subject><subject>Kidney Tubules - physiology</subject><subject>Kidney Tubules, Distal - physiology</subject><subject>Kidney Tubules, Proximal - drug effects</subject><subject>Loop of Henle - physiology</subject><subject>Natriuresis</subject><subject>Perfusion</subject><subject>Prostaglandins - pharmacology</subject><subject>Sodium - metabolism</subject><subject>Water-Electrolyte Balance</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtLxDAQxoMouj7OnoSevHWdSdq0OYmuTxCEVc8hTae71exmbVrE_97s4-Bp4Pc9GD7GzhHGiBKvAMcdhbGQYxmB2mMjzHmWZnmB-2wEACothIAjdhzCJwBmgqtDdoigRJHjiF1PvaPEN0k_p2TinSPbt8tZcjfYPmmXGzyl2eBM3_rl2vjm63ZYJLfGmaWlU3bQGBfobHdP2MfD_fvkKX15fXye3LykVhRCprywFc8qVRHPGsxLXkLJuczIkLSZBWMsNbWJnFSZ16QaWxA2vKmqUtWQixN2ue1ddf57oNDrRRssufgE-SHomMxlwVU0Xm2NtvMhdNToVdcuTPerEfR6Mg2op_dvWkgtI1gnLnbVQ7Wg-p9_s1HUs63-411PXfhyww91ek7G9XMdJwYByFNURQ4yTpxGglL8AZwpdgo</recordid><startdate>197506</startdate><enddate>197506</enddate><creator>Stein, Jay H</creator><creator>Kirschenbaum, Michael A</creator><creator>Bay, William H</creator><creator>Osgood, Richard W</creator><creator>Ferris, Thomas F</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197506</creationdate><title>Role of the Collecting Duct in the Regulation of Sodium Balance</title><author>Stein, Jay H ; Kirschenbaum, Michael A ; Bay, William H ; Osgood, Richard W ; Ferris, Thomas F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3736-27cb24b9be24f15828082264eae6c4c0aacefda828e985de9fc7e1f2fbb89d053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Albumins - pharmacology</topic><topic>Biological Transport</topic><topic>Blood Pressure</topic><topic>Desoxycorticosterone - pharmacology</topic><topic>Diet, Sodium-Restricted</topic><topic>Extracellular Space - metabolism</topic><topic>Glomerular Filtration Rate</topic><topic>Kidney Tubules - physiology</topic><topic>Kidney Tubules, Distal - physiology</topic><topic>Kidney Tubules, Proximal - drug effects</topic><topic>Loop of Henle - physiology</topic><topic>Natriuresis</topic><topic>Perfusion</topic><topic>Prostaglandins - pharmacology</topic><topic>Sodium - metabolism</topic><topic>Water-Electrolyte Balance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stein, Jay H</creatorcontrib><creatorcontrib>Kirschenbaum, Michael A</creatorcontrib><creatorcontrib>Bay, William H</creatorcontrib><creatorcontrib>Osgood, Richard W</creatorcontrib><creatorcontrib>Ferris, Thomas F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stein, Jay H</au><au>Kirschenbaum, Michael A</au><au>Bay, William H</au><au>Osgood, Richard W</au><au>Ferris, Thomas F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the Collecting Duct in the Regulation of Sodium Balance</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1975-06</date><risdate>1975</risdate><volume>36</volume><issue>6 Suppl 1</issue><spage>I-119</spage><epage>I-124</epage><pages>I-119-I-124</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>A large body of evidence has accumulated which demonstrates that sodium transport in some distal nephron segment is altered in response to changes in extracellular fluid volume. Sodium reabsorption in the loop of Henle and distal tubule is directly related to delivery rate and is not inhibited by volume expansion. In contrast, recent studies have shown that Ringer loading causes a greater natriuretic response than hyperoncotic albumin because of diminished collecting duct sodium transport in the former model. Additional studies in animals with different basal extracellular fluid volumes and in DOCA-escape rats indicate further that the collecting duct is an important regulator of sodium balance. Although the factors that modulate sodium transport in the collecting duct are not clear, it is postulated that the local release of prostaglandins may be of major importance.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>1093751</pmid><doi>10.1161/01.res.36.6.119</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7330 |
| ispartof | Circulation research, 1975-06, Vol.36 (6 Suppl 1), p.I-119-I-124 |
| issn | 0009-7330 1524-4571 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82856729 |
| source | MEDLINE; American Heart Association; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Albumins - pharmacology Biological Transport Blood Pressure Desoxycorticosterone - pharmacology Diet, Sodium-Restricted Extracellular Space - metabolism Glomerular Filtration Rate Kidney Tubules - physiology Kidney Tubules, Distal - physiology Kidney Tubules, Proximal - drug effects Loop of Henle - physiology Natriuresis Perfusion Prostaglandins - pharmacology Sodium - metabolism Water-Electrolyte Balance |
| title | Role of the Collecting Duct in the Regulation of Sodium Balance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T16%3A39%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20the%20Collecting%20Duct%20in%20the%20Regulation%20of%20Sodium%20Balance&rft.jtitle=Circulation%20research&rft.au=Stein,%20Jay%20H&rft.date=1975-06&rft.volume=36&rft.issue=6%20Suppl%201&rft.spage=I-119&rft.epage=I-124&rft.pages=I-119-I-124&rft.issn=0009-7330&rft.eissn=1524-4571&rft_id=info:doi/10.1161/01.res.36.6.119&rft_dat=%3Cproquest_cross%3E82856729%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=82856729&rft_id=info:pmid/1093751&rfr_iscdi=true |