Orosomucoid in Schizophrenia
OROSOMUCOID, a glycoprotein extremely rich in carbohydrate, is the principal constituent of the perchloric acid-soluble seromucoid fraction of human serum 1 . In contrast to the seromucoid fraction which contains several proteins and represents more than one biological entity, orosomucoid is homogen...
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| Veröffentlicht in: | Nature (London) 1961-10, Vol.192 (4800), p.370-371 |
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| creator | GOODMAN, M LUBY, E. D FROHMAN, C. E GOTTLIEB, J. S |
| description | OROSOMUCOID, a glycoprotein extremely rich in carbohydrate, is the principal constituent of the perchloric acid-soluble seromucoid fraction of human serum
1
. In contrast to the seromucoid fraction which contains several proteins and represents more than one biological entity, orosomucoid is homogeneous and behaves as a single protein. With the production of specific chicken antiorosomucoid sera
2,3
, it has become possible to investigate the clinical significance of orosomucoid. Interest in doing so arises from the fact that elevations of seromucoid and total serum glycoprotein-levels occur in a number of diseases; for example, in malignancy, tuberculosis, rheumatoid arthritis, and multiple sclerosis
4
. Elevations in this chemically defined group of proteins also occur in response to a wide range of non-specific stressors such as fractures, epinephrine injection, and burns
5
. |
| doi_str_mv | 10.1038/192370a0 |
| format | Article |
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1
. In contrast to the seromucoid fraction which contains several proteins and represents more than one biological entity, orosomucoid is homogeneous and behaves as a single protein. With the production of specific chicken antiorosomucoid sera
2,3
, it has become possible to investigate the clinical significance of orosomucoid. Interest in doing so arises from the fact that elevations of seromucoid and total serum glycoprotein-levels occur in a number of diseases; for example, in malignancy, tuberculosis, rheumatoid arthritis, and multiple sclerosis
4
. Elevations in this chemically defined group of proteins also occur in response to a wide range of non-specific stressors such as fractures, epinephrine injection, and burns
5
.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/192370a0</identifier><identifier>PMID: 13900323</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Glycoproteins - blood ; Humanities and Social Sciences ; Humans ; letter ; multidisciplinary ; Old Medline ; Orosomucoid ; Schizophrenia ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1961-10, Vol.192 (4800), p.370-371</ispartof><rights>Springer Nature Limited 1961</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-f99eb00c52abef898258afc98c552fc81d8fac4fe10fd369b0c5340a3eb4c2763</citedby><cites>FETCH-LOGICAL-c338t-f99eb00c52abef898258afc98c552fc81d8fac4fe10fd369b0c5340a3eb4c2763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/192370a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/192370a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2726,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13900323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOODMAN, M</creatorcontrib><creatorcontrib>LUBY, E. D</creatorcontrib><creatorcontrib>FROHMAN, C. E</creatorcontrib><creatorcontrib>GOTTLIEB, J. S</creatorcontrib><title>Orosomucoid in Schizophrenia</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>OROSOMUCOID, a glycoprotein extremely rich in carbohydrate, is the principal constituent of the perchloric acid-soluble seromucoid fraction of human serum
1
. In contrast to the seromucoid fraction which contains several proteins and represents more than one biological entity, orosomucoid is homogeneous and behaves as a single protein. With the production of specific chicken antiorosomucoid sera
2,3
, it has become possible to investigate the clinical significance of orosomucoid. Interest in doing so arises from the fact that elevations of seromucoid and total serum glycoprotein-levels occur in a number of diseases; for example, in malignancy, tuberculosis, rheumatoid arthritis, and multiple sclerosis
4
. Elevations in this chemically defined group of proteins also occur in response to a wide range of non-specific stressors such as fractures, epinephrine injection, and burns
5
.</description><subject>Glycoproteins - blood</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Orosomucoid</subject><subject>Schizophrenia</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1961</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LAzEQBuAgiq1V8AeI9CR6WJ187O7kWIpfUOhBPYdsNrFbupuadA_66420pTdPc5iHl5mXkEsK9xQ4PlDJeAkajsiQirLIRIHlMRkCMMwAeTEgZzEuASCnpTglA8olAGd8SK7mwUff9sY39bjpxm9m0fz49SLYrtHn5MTpVbQXuzkiH0-P79OXbDZ_fp1OZpnhHDeZk9JWACZnurIOJbIctTMSTZ4zZ5DW6LQRzlJwNS9klSgXoLmthGFlwUfkZpu7Dv6rt3Gj2iYau1rpzvo-KmSYC1FCgrdbaNLVMVin1qFpdfhWFNRfE2rfRKLXu8y-am19gLvXE7jbgphW3acNaun70KU__wnr9KYP9hC2B78LRG5p</recordid><startdate>19611028</startdate><enddate>19611028</enddate><creator>GOODMAN, M</creator><creator>LUBY, E. D</creator><creator>FROHMAN, C. E</creator><creator>GOTTLIEB, J. S</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19611028</creationdate><title>Orosomucoid in Schizophrenia</title><author>GOODMAN, M ; LUBY, E. D ; FROHMAN, C. E ; GOTTLIEB, J. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-f99eb00c52abef898258afc98c552fc81d8fac4fe10fd369b0c5340a3eb4c2763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1961</creationdate><topic>Glycoproteins - blood</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Orosomucoid</topic><topic>Schizophrenia</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOODMAN, M</creatorcontrib><creatorcontrib>LUBY, E. D</creatorcontrib><creatorcontrib>FROHMAN, C. E</creatorcontrib><creatorcontrib>GOTTLIEB, J. S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOODMAN, M</au><au>LUBY, E. D</au><au>FROHMAN, C. E</au><au>GOTTLIEB, J. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Orosomucoid in Schizophrenia</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1961-10-28</date><risdate>1961</risdate><volume>192</volume><issue>4800</issue><spage>370</spage><epage>371</epage><pages>370-371</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>OROSOMUCOID, a glycoprotein extremely rich in carbohydrate, is the principal constituent of the perchloric acid-soluble seromucoid fraction of human serum
1
. In contrast to the seromucoid fraction which contains several proteins and represents more than one biological entity, orosomucoid is homogeneous and behaves as a single protein. With the production of specific chicken antiorosomucoid sera
2,3
, it has become possible to investigate the clinical significance of orosomucoid. Interest in doing so arises from the fact that elevations of seromucoid and total serum glycoprotein-levels occur in a number of diseases; for example, in malignancy, tuberculosis, rheumatoid arthritis, and multiple sclerosis
4
. Elevations in this chemically defined group of proteins also occur in response to a wide range of non-specific stressors such as fractures, epinephrine injection, and burns
5
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>13900323</pmid><doi>10.1038/192370a0</doi><tpages>2</tpages></addata></record> |
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| subjects | Glycoproteins - blood Humanities and Social Sciences Humans letter multidisciplinary Old Medline Orosomucoid Schizophrenia Science Science (multidisciplinary) |
| title | Orosomucoid in Schizophrenia |
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