The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone?
18-Hydroxycorticosterone exhibits a spontaneous interconversion between two forms separable by paper chromatography, a and b. Upon acetylation, both give rise to at least one compound having identical chromatographic properties irrespective of the basic form utilized. Both forms present different ch...
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| Veröffentlicht in: | Journal of steroid biochemistry 1975, Vol.6 (1), p.69-74 |
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| container_title | Journal of steroid biochemistry |
| container_volume | 6 |
| creator | Damasco, Maria Cristina Lantos, Carlos P. |
| description | 18-Hydroxycorticosterone exhibits a spontaneous interconversion between two forms separable by paper chromatography,
a and
b. Upon acetylation, both give rise to at least one compound having identical chromatographic properties irrespective of the basic form utilized. Both forms present different chromatographic patterns upon elution from Sephadex LH 20. The less polar on paper strips (
a) also migrated closer to the solvent front after gel filtration. In repeated experiments,
a proved to be a better precursor for aldosterone-like material than
b. In at least one case, these results could be confirmed for purified aldosterone. Also, the uptake of
a by adrenal tissue is higher than that of
b. |
| doi_str_mv | 10.1016/0022-4731(75)90031-X |
| format | Article |
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a and
b. Upon acetylation, both give rise to at least one compound having identical chromatographic properties irrespective of the basic form utilized. Both forms present different chromatographic patterns upon elution from Sephadex LH 20. The less polar on paper strips (
a) also migrated closer to the solvent front after gel filtration. In repeated experiments,
a proved to be a better precursor for aldosterone-like material than
b. In at least one case, these results could be confirmed for purified aldosterone. Also, the uptake of
a by adrenal tissue is higher than that of
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a and
b. Upon acetylation, both give rise to at least one compound having identical chromatographic properties irrespective of the basic form utilized. Both forms present different chromatographic patterns upon elution from Sephadex LH 20. The less polar on paper strips (
a) also migrated closer to the solvent front after gel filtration. In repeated experiments,
a proved to be a better precursor for aldosterone-like material than
b. In at least one case, these results could be confirmed for purified aldosterone. Also, the uptake of
a by adrenal tissue is higher than that of
b.</description><subject>18-Hydroxycorticosterone - isolation & purification</subject><subject>18-Hydroxycorticosterone - metabolism</subject><subject>Acetylation</subject><subject>Adrenal Glands - metabolism</subject><subject>Aldosterone - metabolism</subject><subject>Animals</subject><subject>Carbon Radioisotopes</subject><subject>Chromatography, Gel</subject><subject>Chromatography, Paper</subject><subject>Corticosterone - analogs & derivatives</subject><subject>Corticosterone - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Solvents</subject><subject>Time Factors</subject><subject>Tritium</subject><issn>0022-4731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxTAQhrNQvL-BQlaii2rSpDcXiog3ENwouAtxOuFE2uaY9Bw94Gv4SL6XqfWycxWY7_8nzEfINmcHnPH8kLE0TWQh-F6R7VeMCZ48LJG13_EqWQ_hiTFelTJdISucC8mqYo283U2Q4qsNPXaA1Bnavzhqux49uG6OvrePDVLjfBsGystksqi9e12AiwxcLHrX4RG9jrwbN0ywpbqjGno7Rzr9eEeY-eD8AHVT_3RONsmy0U3Are93g9xfnN-dXSU3t5fXZ6c3CaRF2idZjVjnJZM6L40xaVnlMl7GQYOOw6pmYAwYzbQWQgDLCmY0CJkLGZMcxQbZHfdOvXueYehVawNg0-gO3SyoMi2zVMoqBuUYBO9C8GjU1NtW-4XiTA2i1WBUDUZVkakv0eoh1na-988eW6z_SqPlyI9HjvHIuUWvAtjBd209Qq9qZ___4BMk9ZIL</recordid><startdate>1975</startdate><enddate>1975</enddate><creator>Damasco, Maria Cristina</creator><creator>Lantos, Carlos P.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1975</creationdate><title>The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone?</title><author>Damasco, Maria Cristina ; Lantos, Carlos P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-5deed6804a68fff289640021caca04a9d0cffcfa0aa333c0570fac346349641e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>18-Hydroxycorticosterone - isolation & purification</topic><topic>18-Hydroxycorticosterone - metabolism</topic><topic>Acetylation</topic><topic>Adrenal Glands - metabolism</topic><topic>Aldosterone - metabolism</topic><topic>Animals</topic><topic>Carbon Radioisotopes</topic><topic>Chromatography, Gel</topic><topic>Chromatography, Paper</topic><topic>Corticosterone - analogs & derivatives</topic><topic>Corticosterone - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Solvents</topic><topic>Time Factors</topic><topic>Tritium</topic><toplevel>online_resources</toplevel><creatorcontrib>Damasco, Maria Cristina</creatorcontrib><creatorcontrib>Lantos, Carlos P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of steroid biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Damasco, Maria Cristina</au><au>Lantos, Carlos P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone?</atitle><jtitle>Journal of steroid biochemistry</jtitle><addtitle>J Steroid Biochem</addtitle><date>1975</date><risdate>1975</risdate><volume>6</volume><issue>1</issue><spage>69</spage><epage>74</epage><pages>69-74</pages><issn>0022-4731</issn><abstract>18-Hydroxycorticosterone exhibits a spontaneous interconversion between two forms separable by paper chromatography,
a and
b. Upon acetylation, both give rise to at least one compound having identical chromatographic properties irrespective of the basic form utilized. Both forms present different chromatographic patterns upon elution from Sephadex LH 20. The less polar on paper strips (
a) also migrated closer to the solvent front after gel filtration. In repeated experiments,
a proved to be a better precursor for aldosterone-like material than
b. In at least one case, these results could be confirmed for purified aldosterone. Also, the uptake of
a by adrenal tissue is higher than that of
b.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>1134097</pmid><doi>10.1016/0022-4731(75)90031-X</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4731 |
| ispartof | Journal of steroid biochemistry, 1975, Vol.6 (1), p.69-74 |
| issn | 0022-4731 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82852449 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 18-Hydroxycorticosterone - isolation & purification 18-Hydroxycorticosterone - metabolism Acetylation Adrenal Glands - metabolism Aldosterone - metabolism Animals Carbon Radioisotopes Chromatography, Gel Chromatography, Paper Corticosterone - analogs & derivatives Corticosterone - metabolism Male Rats Solvents Time Factors Tritium |
| title | The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone? |
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