Analgesic properties of the tetrahydrocannabinols, their metabolites, and analogs

The tetrahydrocannabinols from marihuana were found to have moderate analgesic activity in mice by the hot-plate test (sc administration). Of the several metabolites of these two compounds tested, only the 11-hydroxy derivatives were more potent than the parent compounds. Analogs 1 and 2 (9-demethyl...

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Veröffentlicht in:	Journal of medicinal chemistry 1975-07, Vol.18 (7), p.700-703
Hauptverfasser:	Wilson, Raymond S, May, Everette L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - chemical synthesis Animals Cannabis Dronabinol - chemical synthesis Dronabinol - metabolism Dronabinol - pharmacology Electroshock Hot Temperature Magnetic Resonance Spectroscopy Mice Reaction Time - drug effects
Online-Zugang:	Volltext
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