Determination of Argininosuccinic Acid by Ion-Exchange Chromatography
RECENTLY, an unknown amino-acid excreted in the urine by two mentally defective children 1 was identified as argininosuccinic acid (ASA) 2 . This is unstable in weakly acid aqueous solutions and cyclizes 3 . More recently Westall 4 has shown that under these conditions two separate types of anhydrid...
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| Veröffentlicht in: | Nature (London) 1961-11, Vol.192 (4802), p.555-556 |
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| creator | CUSWORTH, D. C. WESTALL, R. G. |
| description | RECENTLY, an unknown amino-acid excreted in the urine by two mentally defective children
1
was identified as argininosuccinic acid (ASA)
2
. This is unstable in weakly acid aqueous solutions and cyclizes
3
. More recently Westall
4
has shown that under these conditions two separate types of anhydride (
B
and
C
) are formed, rapidly at high but more slowly at room temperatures. |
| doi_str_mv | 10.1038/192555a0 |
| format | Article |
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1
was identified as argininosuccinic acid (ASA)
2
. This is unstable in weakly acid aqueous solutions and cyclizes
3
. More recently Westall
4
has shown that under these conditions two separate types of anhydride (
B
and
C
) are formed, rapidly at high but more slowly at room temperatures.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/192555a0</identifier><identifier>PMID: 13882794</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Arginine - analogs & derivatives ; Argininosuccinic Acid ; Chromatography, Ion Exchange ; Humanities and Social Sciences ; letter ; multidisciplinary ; Old Medline ; Science ; Science (multidisciplinary) ; Succinates - chemistry</subject><ispartof>Nature (London), 1961-11, Vol.192 (4802), p.555-556</ispartof><rights>Springer Nature Limited 1961</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-182631606bc8375d289645acaffd18d7e98bb86aba578f66183a375e5f4367b13</citedby><cites>FETCH-LOGICAL-c381t-182631606bc8375d289645acaffd18d7e98bb86aba578f66183a375e5f4367b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/192555a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/192555a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13882794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CUSWORTH, D. C.</creatorcontrib><creatorcontrib>WESTALL, R. G.</creatorcontrib><title>Determination of Argininosuccinic Acid by Ion-Exchange Chromatography</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>RECENTLY, an unknown amino-acid excreted in the urine by two mentally defective children
1
was identified as argininosuccinic acid (ASA)
2
. This is unstable in weakly acid aqueous solutions and cyclizes
3
. More recently Westall
4
has shown that under these conditions two separate types of anhydride (
B
and
C
) are formed, rapidly at high but more slowly at room temperatures.</description><subject>Arginine - analogs & derivatives</subject><subject>Argininosuccinic Acid</subject><subject>Chromatography, Ion Exchange</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Succinates - chemistry</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1961</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0E1LAzEQBuAgiq1V8BfInkQPq8nma_ZYatVCwYueQzabbbd0k5rsgv33Rlrx4GkG5uGFeRG6JviBYAqPpCw45xqfoDFhUuRMgDxFY4wLyDFQMUIXMW4wxpxIdo5GhAIUsmRjNH-yvQ1d63Tfepf5JpuGVeta5-NgTFpMNjVtnVX7bOFdPv8ya-1WNputg-9071dB79b7S3TW6G20V8c5QR_P8_fZa758e1nMpsvcUCB9TqAQlAgsKgNU8rqAUjCujW6amkAtbQlVBUJXmktohCBAdXKWN4wKWRE6QbeH3F3wn4ONveraaOx2q531Q1RQAJOSiQTvDtAEH2OwjdqFttNhrwhWP5Wp38oSvTlmDlVn6z947CiB-wOI6ZR-D2rjh-DSn__DvgEcGXKB</recordid><startdate>19611111</startdate><enddate>19611111</enddate><creator>CUSWORTH, D. C.</creator><creator>WESTALL, R. G.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19611111</creationdate><title>Determination of Argininosuccinic Acid by Ion-Exchange Chromatography</title><author>CUSWORTH, D. C. ; WESTALL, R. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-182631606bc8375d289645acaffd18d7e98bb86aba578f66183a375e5f4367b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1961</creationdate><topic>Arginine - analogs & derivatives</topic><topic>Argininosuccinic Acid</topic><topic>Chromatography, Ion Exchange</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Succinates - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CUSWORTH, D. C.</creatorcontrib><creatorcontrib>WESTALL, R. G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CUSWORTH, D. C.</au><au>WESTALL, R. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of Argininosuccinic Acid by Ion-Exchange Chromatography</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1961-11-11</date><risdate>1961</risdate><volume>192</volume><issue>4802</issue><spage>555</spage><epage>556</epage><pages>555-556</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>RECENTLY, an unknown amino-acid excreted in the urine by two mentally defective children
1
was identified as argininosuccinic acid (ASA)
2
. This is unstable in weakly acid aqueous solutions and cyclizes
3
. More recently Westall
4
has shown that under these conditions two separate types of anhydride (
B
and
C
) are formed, rapidly at high but more slowly at room temperatures.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>13882794</pmid><doi>10.1038/192555a0</doi><tpages>2</tpages></addata></record> |
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| ispartof | Nature (London), 1961-11, Vol.192 (4802), p.555-556 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Arginine - analogs & derivatives Argininosuccinic Acid Chromatography, Ion Exchange Humanities and Social Sciences letter multidisciplinary Old Medline Science Science (multidisciplinary) Succinates - chemistry |
| title | Determination of Argininosuccinic Acid by Ion-Exchange Chromatography |
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