The pulmonary vascular bed in children with Down syndrome
Sixty-nine children with Down syndrome (mongolism, trisomy 21), with atrial septal defect, patent ductus arteriosus, ventricular septal defect, or endocardial cushion defects, and 315 children with similar cardiac anomalies without this syndrome underwent cardiac catheterization during an 8-year per...
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| Veröffentlicht in: | The Journal of pediatrics 1975-04, Vol.86 (4), p.533-538 |
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| container_title | The Journal of pediatrics |
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| creator | Chi, TzehPing L. Krovetz, L. Jerome |
| description | Sixty-nine children with Down syndrome (mongolism, trisomy 21), with atrial septal defect, patent ductus arteriosus, ventricular septal defect, or endocardial cushion defects, and 315 children with similar cardiac anomalies without this syndrome underwent cardiac catheterization during an 8-year period from 1964 to 1973. Only patients under 17 years of age were included in the study. Nine tenths of the children with Down syndrome but only one fourth of the control group had abnormally high pulmonary arterial pressures. For example, 9 of 11 children with defects of the atrial septum and Down syndrome had pulmonary hypertension; in contrast, only 5 of 55 control subjects with similar defects had pulmonary hypertension. The data suggest that children with congenital heart disease and Down syndrome have an unusually high pulmonary vascular resistance and a propensity for early development of severe damage to the pulmonary vascular bed. |
| doi_str_mv | 10.1016/S0022-3476(75)80142-9 |
| format | Article |
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The data suggest that children with congenital heart disease and Down syndrome have an unusually high pulmonary vascular resistance and a propensity for early development of severe damage to the pulmonary vascular bed.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(75)80142-9</identifier><identifier>PMID: 123955</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adolescent ; Blood Pressure ; Cardiac Catheterization ; Child ; Child, Preschool ; Down Syndrome - complications ; Down Syndrome - physiopathology ; Ductus Arteriosus, Patent - complications ; Ductus Arteriosus, Patent - physiopathology ; Heart Defects, Congenital - complications ; Heart Defects, Congenital - physiopathology ; Heart Septal Defects, Atrial - complications ; Heart Septal Defects, Atrial - physiopathology ; Heart Septal Defects, Ventricular - complications ; Heart Septal Defects, Ventricular - physiopathology ; Humans ; Hypertension, Pulmonary - etiology ; Hypertension, Pulmonary - physiopathology ; Infant ; Infant, Newborn ; Pulmonary Artery - physiopathology ; Pulmonary Circulation ; Vascular Resistance</subject><ispartof>The Journal of pediatrics, 1975-04, Vol.86 (4), p.533-538</ispartof><rights>1975 The C. V. Mosby Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-4347efb106a0f58dda71cb8378d55351f5b7a5bd1ec363c59e14de57a0ef8173</citedby><cites>FETCH-LOGICAL-c359t-4347efb106a0f58dda71cb8378d55351f5b7a5bd1ec363c59e14de57a0ef8173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347675801429$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/123955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chi, TzehPing L.</creatorcontrib><creatorcontrib>Krovetz, L. Jerome</creatorcontrib><title>The pulmonary vascular bed in children with Down syndrome</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Sixty-nine children with Down syndrome (mongolism, trisomy 21), with atrial septal defect, patent ductus arteriosus, ventricular septal defect, or endocardial cushion defects, and 315 children with similar cardiac anomalies without this syndrome underwent cardiac catheterization during an 8-year period from 1964 to 1973. Only patients under 17 years of age were included in the study. Nine tenths of the children with Down syndrome but only one fourth of the control group had abnormally high pulmonary arterial pressures. For example, 9 of 11 children with defects of the atrial septum and Down syndrome had pulmonary hypertension; in contrast, only 5 of 55 control subjects with similar defects had pulmonary hypertension. The data suggest that children with congenital heart disease and Down syndrome have an unusually high pulmonary vascular resistance and a propensity for early development of severe damage to the pulmonary vascular bed.</description><subject>Adolescent</subject><subject>Blood Pressure</subject><subject>Cardiac Catheterization</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Down Syndrome - complications</subject><subject>Down Syndrome - physiopathology</subject><subject>Ductus Arteriosus, Patent - complications</subject><subject>Ductus Arteriosus, Patent - physiopathology</subject><subject>Heart Defects, Congenital - complications</subject><subject>Heart Defects, Congenital - physiopathology</subject><subject>Heart Septal Defects, Atrial - complications</subject><subject>Heart Septal Defects, Atrial - physiopathology</subject><subject>Heart Septal Defects, Ventricular - complications</subject><subject>Heart Septal Defects, Ventricular - physiopathology</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Pulmonary Artery - physiopathology</subject><subject>Pulmonary Circulation</subject><subject>Vascular Resistance</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElPwzAUhC3EVgr_ACSfEBwCdhzH9gmhskqVONC75dgvqlGWYiet-u9JF8GR0zvMzBvNh9AVJXeU0Pz-k5A0TVgm8hvBbyWhWZqoAzSiRIkkl4wdotGv5RSdxfhFCFEZISfomKZMcT5CajYHvOirum1MWOOlibavTMAFOOwbbOe-cgEavPLdHD-1qwbHdeNCW8M5OipNFeFif8do9vI8m7wl04_X98njNLGMqy7JhnYoC0pyQ0ounTOC2kIyIR3njNOSF8LwwlGwLGeWK6CZAy4MgVJSwcboevd2EdrvHmKnax8tVJVpoO2jlqnMhGBkMPKd0YY2xgClXgRfD6M0JXoDTG-B6Q0NLbjeAtNqyF3uC_qiBveX2hIa5IedDMPGpYego_XQWHA-gO20a_0_BT8HFXn2</recordid><startdate>197504</startdate><enddate>197504</enddate><creator>Chi, TzehPing L.</creator><creator>Krovetz, L. Jerome</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197504</creationdate><title>The pulmonary vascular bed in children with Down syndrome</title><author>Chi, TzehPing L. ; Krovetz, L. Jerome</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-4347efb106a0f58dda71cb8378d55351f5b7a5bd1ec363c59e14de57a0ef8173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adolescent</topic><topic>Blood Pressure</topic><topic>Cardiac Catheterization</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Down Syndrome - complications</topic><topic>Down Syndrome - physiopathology</topic><topic>Ductus Arteriosus, Patent - complications</topic><topic>Ductus Arteriosus, Patent - physiopathology</topic><topic>Heart Defects, Congenital - complications</topic><topic>Heart Defects, Congenital - physiopathology</topic><topic>Heart Septal Defects, Atrial - complications</topic><topic>Heart Septal Defects, Atrial - physiopathology</topic><topic>Heart Septal Defects, Ventricular - complications</topic><topic>Heart Septal Defects, Ventricular - physiopathology</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - etiology</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Pulmonary Artery - physiopathology</topic><topic>Pulmonary Circulation</topic><topic>Vascular Resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chi, TzehPing L.</creatorcontrib><creatorcontrib>Krovetz, L. Jerome</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chi, TzehPing L.</au><au>Krovetz, L. Jerome</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pulmonary vascular bed in children with Down syndrome</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1975-04</date><risdate>1975</risdate><volume>86</volume><issue>4</issue><spage>533</spage><epage>538</epage><pages>533-538</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Sixty-nine children with Down syndrome (mongolism, trisomy 21), with atrial septal defect, patent ductus arteriosus, ventricular septal defect, or endocardial cushion defects, and 315 children with similar cardiac anomalies without this syndrome underwent cardiac catheterization during an 8-year period from 1964 to 1973. Only patients under 17 years of age were included in the study. Nine tenths of the children with Down syndrome but only one fourth of the control group had abnormally high pulmonary arterial pressures. For example, 9 of 11 children with defects of the atrial septum and Down syndrome had pulmonary hypertension; in contrast, only 5 of 55 control subjects with similar defects had pulmonary hypertension. The data suggest that children with congenital heart disease and Down syndrome have an unusually high pulmonary vascular resistance and a propensity for early development of severe damage to the pulmonary vascular bed.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>123955</pmid><doi>10.1016/S0022-3476(75)80142-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 1975-04, Vol.86 (4), p.533-538 |
| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Blood Pressure Cardiac Catheterization Child Child, Preschool Down Syndrome - complications Down Syndrome - physiopathology Ductus Arteriosus, Patent - complications Ductus Arteriosus, Patent - physiopathology Heart Defects, Congenital - complications Heart Defects, Congenital - physiopathology Heart Septal Defects, Atrial - complications Heart Septal Defects, Atrial - physiopathology Heart Septal Defects, Ventricular - complications Heart Septal Defects, Ventricular - physiopathology Humans Hypertension, Pulmonary - etiology Hypertension, Pulmonary - physiopathology Infant Infant, Newborn Pulmonary Artery - physiopathology Pulmonary Circulation Vascular Resistance |
| title | The pulmonary vascular bed in children with Down syndrome |
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