Experimental Cerebral Vasospasm and Cyclic Adenosine Monophosphate (c-AMP)
Blood induced acute and chronic cerebral vasospasm were studied in Rhesus monkeys by serial angiography. Two vasoactive agents were evaluated. In acute spasm, phosphodiesterase inhibition by Aminophylline consistently reversed the vasospasm. This agent alone was ineffective in chronic spasm and requ...
Gespeichert in:
| Veröffentlicht in: | Investigative radiology 1975-05, Vol.10 (3), p.239-243 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 243 |
|---|---|
| container_issue | 3 |
| container_start_page | 239 |
| container_title | Investigative radiology |
| container_volume | 10 |
| creator | Kim, Jhinho Flamm, Eugene S Lin, Joseph |
| description | Blood induced acute and chronic cerebral vasospasm were studied in Rhesus monkeys by serial angiography. Two vasoactive agents were evaluated. In acute spasm, phosphodiesterase inhibition by Aminophylline consistently reversed the vasospasm. This agent alone was ineffective in chronic spasm and required the addition of Isoproterenol to produce reversal of vasospasm. It is proposed that cerebral vasospasm may be associated with a decrease of intracellular c-AMP in vascular smooth muscle which can be reversed by manipulation of the enzyme pathway involved. It is further proposed that c-AMP is a basic common pathway through which adrenergic vascular reactivities are mediated. |
| doi_str_mv | 10.1097/00004424-197505000-00008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_82846785</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>82846785</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3548-5a63c1da817df650800a31e85feb39d8f04f1ef39564af9cef298aa3b3d14eaf3</originalsourceid><addsrcrecordid>eNp1UclOwzAQtRBbKfwBh5wQHAJ2bCf2sYrKplZwAK6Wk4yVQJoEO1Hp3-MuwIm5zPbejOYNQgHB1wTL5AZ7YyxiIZEJx9xn4bok9tCIcBqHOCJ4H40wjnAopYyP0Ylz7x4RJZgeoUMSx5hHI_Q4_erAVgtoel0HKVjIrA_etGtdp90i0E0RpKu8rvJgUkDTuqqBYN42bVd6RKl7CC7zcDJ_vjpFB0bXDs52foxeb6cv6X04e7p7SCezMKeciZDrmOak0IIkhYk5FhhrSkBwAxmVhTCYGQKGSh4zbWQOJpJCa5rRgjDQho7RxXZuZ9vPAVyvFpXLoa51A-3glIgEixPBPVBsgbltnbNgVOcv1XalCFZrFdWPiupXxU1JeOr5bseQLaD4I25k8222bS_bugfrPuphCVaVoOu-VP_9hn4DA_d8BQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>82846785</pqid></control><display><type>article</type><title>Experimental Cerebral Vasospasm and Cyclic Adenosine Monophosphate (c-AMP)</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Kim, Jhinho ; Flamm, Eugene S ; Lin, Joseph</creator><creatorcontrib>Kim, Jhinho ; Flamm, Eugene S ; Lin, Joseph</creatorcontrib><description>Blood induced acute and chronic cerebral vasospasm were studied in Rhesus monkeys by serial angiography. Two vasoactive agents were evaluated. In acute spasm, phosphodiesterase inhibition by Aminophylline consistently reversed the vasospasm. This agent alone was ineffective in chronic spasm and required the addition of Isoproterenol to produce reversal of vasospasm. It is proposed that cerebral vasospasm may be associated with a decrease of intracellular c-AMP in vascular smooth muscle which can be reversed by manipulation of the enzyme pathway involved. It is further proposed that c-AMP is a basic common pathway through which adrenergic vascular reactivities are mediated.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-197505000-00008</identifier><identifier>PMID: 166052</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Aminophylline - therapeutic use ; Animals ; Cerebral Angiography ; Cyclic AMP - physiology ; Ischemic Attack, Transient - drug therapy ; Ischemic Attack, Transient - etiology ; Isoproterenol - therapeutic use ; Macaca mulatta ; Phosphodiesterase Inhibitors ; Time Factors ; Vasodilator Agents - therapeutic use</subject><ispartof>Investigative radiology, 1975-05, Vol.10 (3), p.239-243</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3548-5a63c1da817df650800a31e85feb39d8f04f1ef39564af9cef298aa3b3d14eaf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/166052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jhinho</creatorcontrib><creatorcontrib>Flamm, Eugene S</creatorcontrib><creatorcontrib>Lin, Joseph</creatorcontrib><title>Experimental Cerebral Vasospasm and Cyclic Adenosine Monophosphate (c-AMP)</title><title>Investigative radiology</title><addtitle>Invest Radiol</addtitle><description>Blood induced acute and chronic cerebral vasospasm were studied in Rhesus monkeys by serial angiography. Two vasoactive agents were evaluated. In acute spasm, phosphodiesterase inhibition by Aminophylline consistently reversed the vasospasm. This agent alone was ineffective in chronic spasm and required the addition of Isoproterenol to produce reversal of vasospasm. It is proposed that cerebral vasospasm may be associated with a decrease of intracellular c-AMP in vascular smooth muscle which can be reversed by manipulation of the enzyme pathway involved. It is further proposed that c-AMP is a basic common pathway through which adrenergic vascular reactivities are mediated.</description><subject>Aminophylline - therapeutic use</subject><subject>Animals</subject><subject>Cerebral Angiography</subject><subject>Cyclic AMP - physiology</subject><subject>Ischemic Attack, Transient - drug therapy</subject><subject>Ischemic Attack, Transient - etiology</subject><subject>Isoproterenol - therapeutic use</subject><subject>Macaca mulatta</subject><subject>Phosphodiesterase Inhibitors</subject><subject>Time Factors</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UclOwzAQtRBbKfwBh5wQHAJ2bCf2sYrKplZwAK6Wk4yVQJoEO1Hp3-MuwIm5zPbejOYNQgHB1wTL5AZ7YyxiIZEJx9xn4bok9tCIcBqHOCJ4H40wjnAopYyP0Ylz7x4RJZgeoUMSx5hHI_Q4_erAVgtoel0HKVjIrA_etGtdp90i0E0RpKu8rvJgUkDTuqqBYN42bVd6RKl7CC7zcDJ_vjpFB0bXDs52foxeb6cv6X04e7p7SCezMKeciZDrmOak0IIkhYk5FhhrSkBwAxmVhTCYGQKGSh4zbWQOJpJCa5rRgjDQho7RxXZuZ9vPAVyvFpXLoa51A-3glIgEixPBPVBsgbltnbNgVOcv1XalCFZrFdWPiupXxU1JeOr5bseQLaD4I25k8222bS_bugfrPuphCVaVoOu-VP_9hn4DA_d8BQ</recordid><startdate>197505</startdate><enddate>197505</enddate><creator>Kim, Jhinho</creator><creator>Flamm, Eugene S</creator><creator>Lin, Joseph</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197505</creationdate><title>Experimental Cerebral Vasospasm and Cyclic Adenosine Monophosphate (c-AMP)</title><author>Kim, Jhinho ; Flamm, Eugene S ; Lin, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3548-5a63c1da817df650800a31e85feb39d8f04f1ef39564af9cef298aa3b3d14eaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Aminophylline - therapeutic use</topic><topic>Animals</topic><topic>Cerebral Angiography</topic><topic>Cyclic AMP - physiology</topic><topic>Ischemic Attack, Transient - drug therapy</topic><topic>Ischemic Attack, Transient - etiology</topic><topic>Isoproterenol - therapeutic use</topic><topic>Macaca mulatta</topic><topic>Phosphodiesterase Inhibitors</topic><topic>Time Factors</topic><topic>Vasodilator Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jhinho</creatorcontrib><creatorcontrib>Flamm, Eugene S</creatorcontrib><creatorcontrib>Lin, Joseph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jhinho</au><au>Flamm, Eugene S</au><au>Lin, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Cerebral Vasospasm and Cyclic Adenosine Monophosphate (c-AMP)</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>1975-05</date><risdate>1975</risdate><volume>10</volume><issue>3</issue><spage>239</spage><epage>243</epage><pages>239-243</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>Blood induced acute and chronic cerebral vasospasm were studied in Rhesus monkeys by serial angiography. Two vasoactive agents were evaluated. In acute spasm, phosphodiesterase inhibition by Aminophylline consistently reversed the vasospasm. This agent alone was ineffective in chronic spasm and required the addition of Isoproterenol to produce reversal of vasospasm. It is proposed that cerebral vasospasm may be associated with a decrease of intracellular c-AMP in vascular smooth muscle which can be reversed by manipulation of the enzyme pathway involved. It is further proposed that c-AMP is a basic common pathway through which adrenergic vascular reactivities are mediated.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>166052</pmid><doi>10.1097/00004424-197505000-00008</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-9996 |
| ispartof | Investigative radiology, 1975-05, Vol.10 (3), p.239-243 |
| issn | 0020-9996 1536-0210 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82846785 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aminophylline - therapeutic use Animals Cerebral Angiography Cyclic AMP - physiology Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - etiology Isoproterenol - therapeutic use Macaca mulatta Phosphodiesterase Inhibitors Time Factors Vasodilator Agents - therapeutic use |
| title | Experimental Cerebral Vasospasm and Cyclic Adenosine Monophosphate (c-AMP) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T03%3A12%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Experimental%20Cerebral%20Vasospasm%20and%20Cyclic%20Adenosine%20Monophosphate%20(c-AMP)&rft.jtitle=Investigative%20radiology&rft.au=Kim,%20Jhinho&rft.date=1975-05&rft.volume=10&rft.issue=3&rft.spage=239&rft.epage=243&rft.pages=239-243&rft.issn=0020-9996&rft.eissn=1536-0210&rft_id=info:doi/10.1097/00004424-197505000-00008&rft_dat=%3Cproquest_cross%3E82846785%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=82846785&rft_id=info:pmid/166052&rfr_iscdi=true |