Induction and suppression of hepatic and extrahepatic microsomal foreign-compound-metabolizing enzyme systems by 2,3,7,8-tetrachlorodibenzo- p-dioxin

The effects of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) on a number of hepatic and extrahepatic foreign-compound-metabolizing enzyme systems in microsomes from rats, rabbits and guinea pigs were investigated. Following TCDD treatment, the N-demethylation of benzphetamine, aminopyrine and ethylmor...

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Veröffentlicht in:	Chemico-biological interactions 1975-03, Vol.10 (3), p.199-214
Hauptverfasser:	Hook, C.E.R., Haseman, J.K., Lucier, G.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzopyrenes Benzyl Compounds - pharmacology Brain - drug effects Brain - enzymology Cytochrome P-450 Enzyme System - metabolism Cytochromes - metabolism Dioxins - pharmacology Female Glucuronosyltransferase - metabolism Guinea Pigs Male Microsomes - drug effects Microsomes - enzymology Microsomes, Liver - drug effects Microsomes, Liver - enzymology Mixed Function Oxygenases - metabolism Oxidoreductases, N-Demethylating - metabolism Rabbits Rats Sex Factors Species Specificity
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