Prostaglandins, antipyretic analgesics and adrenergic stimuli on the isolated artery
In untreated, and cocaine- and DOCA-treated rabbit ear arteries, PGE 2 and arachidonic acid depressed the responses to intramural sympathetic nerve stimulation. Constrictor responses to extraluminal NA in the treated arteries were also depressed. A comparison of its inhibitory potency on the two typ...
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| Veröffentlicht in: | European journal of pharmacology 1975-02, Vol.30 (2), p.319-327 |
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| container_title | European journal of pharmacology |
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| creator | De la Lande, Ivan S. Hall, Rodney C. Kennedy, Jennifer A. Higgins, Geoffrey D. |
| description | In untreated, and cocaine- and DOCA-treated rabbit ear arteries, PGE
2 and arachidonic acid depressed the responses to intramural sympathetic nerve stimulation. Constrictor responses to extraluminal NA in the treated arteries were also depressed. A comparison of its inhibitory potency on the two types of responses suggest that the effects of PGE
2 on responses to adrenergic nerve stimuli are due, in part, to depression of sensitivity to NA. The effects of arachidonic acid, but not PGE
2 on adrenergic nerve stimuli, were selectively blocked by aspirin 200 μg/ml and by indomethacin 3 μg/ml. In these concentrations, aspirin, but not indomethacin, enhanced the magnitude of the responses to the stimuli. Aspirin also selectively reduced the inhibition by arachidonic acid of the response to extraluminal NA (tested in cocaine- and DOCA-treated arteries). |
| doi_str_mv | 10.1016/0014-2999(75)90116-8 |
| format | Article |
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2 and arachidonic acid depressed the responses to intramural sympathetic nerve stimulation. Constrictor responses to extraluminal NA in the treated arteries were also depressed. A comparison of its inhibitory potency on the two types of responses suggest that the effects of PGE
2 on responses to adrenergic nerve stimuli are due, in part, to depression of sensitivity to NA. The effects of arachidonic acid, but not PGE
2 on adrenergic nerve stimuli, were selectively blocked by aspirin 200 μg/ml and by indomethacin 3 μg/ml. In these concentrations, aspirin, but not indomethacin, enhanced the magnitude of the responses to the stimuli. Aspirin also selectively reduced the inhibition by arachidonic acid of the response to extraluminal NA (tested in cocaine- and DOCA-treated arteries).</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(75)90116-8</identifier><identifier>PMID: 1126367</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>8,11,14-Eicosatrienoic Acid - pharmacology ; Analgesics - pharmacology ; Animals ; Arachid acid ; Arachidonic Acids - pharmacology ; Arteries - drug effects ; Artery ; Aspirin ; Aspirin - pharmacology ; Cocaine - pharmacology ; Electric Stimulation ; In Vitro Techniques ; Indomethacin ; Indomethacin - pharmacology ; Noradrenaline ; Norepinephrine - pharmacology ; PGE 2 ; Prostaglandins - pharmacology ; Rabbits ; Sympathetic Nervous System - physiology</subject><ispartof>European journal of pharmacology, 1975-02, Vol.30 (2), p.319-327</ispartof><rights>1975</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-403597c71c3743ec8b3d48433e2cf77f60bccf0fd8abf5c1e27478ec5831e35e3</citedby><cites>FETCH-LOGICAL-c357t-403597c71c3743ec8b3d48433e2cf77f60bccf0fd8abf5c1e27478ec5831e35e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299975901168$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1126367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De la Lande, Ivan S.</creatorcontrib><creatorcontrib>Hall, Rodney C.</creatorcontrib><creatorcontrib>Kennedy, Jennifer A.</creatorcontrib><creatorcontrib>Higgins, Geoffrey D.</creatorcontrib><title>Prostaglandins, antipyretic analgesics and adrenergic stimuli on the isolated artery</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>In untreated, and cocaine- and DOCA-treated rabbit ear arteries, PGE
2 and arachidonic acid depressed the responses to intramural sympathetic nerve stimulation. Constrictor responses to extraluminal NA in the treated arteries were also depressed. A comparison of its inhibitory potency on the two types of responses suggest that the effects of PGE
2 on responses to adrenergic nerve stimuli are due, in part, to depression of sensitivity to NA. The effects of arachidonic acid, but not PGE
2 on adrenergic nerve stimuli, were selectively blocked by aspirin 200 μg/ml and by indomethacin 3 μg/ml. In these concentrations, aspirin, but not indomethacin, enhanced the magnitude of the responses to the stimuli. Aspirin also selectively reduced the inhibition by arachidonic acid of the response to extraluminal NA (tested in cocaine- and DOCA-treated arteries).</description><subject>8,11,14-Eicosatrienoic Acid - pharmacology</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Arachid acid</subject><subject>Arachidonic Acids - pharmacology</subject><subject>Arteries - drug effects</subject><subject>Artery</subject><subject>Aspirin</subject><subject>Aspirin - pharmacology</subject><subject>Cocaine - pharmacology</subject><subject>Electric Stimulation</subject><subject>In Vitro Techniques</subject><subject>Indomethacin</subject><subject>Indomethacin - pharmacology</subject><subject>Noradrenaline</subject><subject>Norepinephrine - pharmacology</subject><subject>PGE 2</subject><subject>Prostaglandins - pharmacology</subject><subject>Rabbits</subject><subject>Sympathetic Nervous System - physiology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4zj6DxS6EgWrSdM06UaQwRcM6GJchzS5HSN9jEkqzL83YwfduboXzjn3cj6ETgm-JpgUNxiTPM3Ksrzg7LLEhBSp2ENTIniZYk6yfTT9tRyiI-8_MMaszNgETQjJClrwKVq-ut4HtWpUZ2znrxLVBbveOAhWx101K_BW-7iaRBkHHbhVVHyw7dDYpO-S8A6J9X2jAkSLC-A2x-igVo2Hk92cobeH--X8KV28PD7P7xappoyHNMeUlVxzoinPKWhRUZOLnFLIdM15XeBK6xrXRqiqZppAxnMuQDNBCVAGdIbOx7tr138O4INsrdfQxDLQD16KTBCCOY3GfDTq2NY7qOXa2Va5jSRYbmHKLSm5JSU5kz8wpYixs939oWrB_IVGelG_HXWIJb8sOOm1hU6DsQ50kKa3_z_4BtQrhJo</recordid><startdate>197502</startdate><enddate>197502</enddate><creator>De la Lande, Ivan S.</creator><creator>Hall, Rodney C.</creator><creator>Kennedy, Jennifer A.</creator><creator>Higgins, Geoffrey D.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197502</creationdate><title>Prostaglandins, antipyretic analgesics and adrenergic stimuli on the isolated artery</title><author>De la Lande, Ivan S. ; Hall, Rodney C. ; Kennedy, Jennifer A. ; Higgins, Geoffrey D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-403597c71c3743ec8b3d48433e2cf77f60bccf0fd8abf5c1e27478ec5831e35e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>8,11,14-Eicosatrienoic Acid - pharmacology</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Arachid acid</topic><topic>Arachidonic Acids - pharmacology</topic><topic>Arteries - drug effects</topic><topic>Artery</topic><topic>Aspirin</topic><topic>Aspirin - pharmacology</topic><topic>Cocaine - pharmacology</topic><topic>Electric Stimulation</topic><topic>In Vitro Techniques</topic><topic>Indomethacin</topic><topic>Indomethacin - pharmacology</topic><topic>Noradrenaline</topic><topic>Norepinephrine - pharmacology</topic><topic>PGE 2</topic><topic>Prostaglandins - pharmacology</topic><topic>Rabbits</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De la Lande, Ivan S.</creatorcontrib><creatorcontrib>Hall, Rodney C.</creatorcontrib><creatorcontrib>Kennedy, Jennifer A.</creatorcontrib><creatorcontrib>Higgins, Geoffrey D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De la Lande, Ivan S.</au><au>Hall, Rodney C.</au><au>Kennedy, Jennifer A.</au><au>Higgins, Geoffrey D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostaglandins, antipyretic analgesics and adrenergic stimuli on the isolated artery</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1975-02</date><risdate>1975</risdate><volume>30</volume><issue>2</issue><spage>319</spage><epage>327</epage><pages>319-327</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>In untreated, and cocaine- and DOCA-treated rabbit ear arteries, PGE
2 and arachidonic acid depressed the responses to intramural sympathetic nerve stimulation. Constrictor responses to extraluminal NA in the treated arteries were also depressed. A comparison of its inhibitory potency on the two types of responses suggest that the effects of PGE
2 on responses to adrenergic nerve stimuli are due, in part, to depression of sensitivity to NA. The effects of arachidonic acid, but not PGE
2 on adrenergic nerve stimuli, were selectively blocked by aspirin 200 μg/ml and by indomethacin 3 μg/ml. In these concentrations, aspirin, but not indomethacin, enhanced the magnitude of the responses to the stimuli. Aspirin also selectively reduced the inhibition by arachidonic acid of the response to extraluminal NA (tested in cocaine- and DOCA-treated arteries).</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>1126367</pmid><doi>10.1016/0014-2999(75)90116-8</doi><tpages>9</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1975-02, Vol.30 (2), p.319-327 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 8,11,14-Eicosatrienoic Acid - pharmacology Analgesics - pharmacology Animals Arachid acid Arachidonic Acids - pharmacology Arteries - drug effects Artery Aspirin Aspirin - pharmacology Cocaine - pharmacology Electric Stimulation In Vitro Techniques Indomethacin Indomethacin - pharmacology Noradrenaline Norepinephrine - pharmacology PGE 2 Prostaglandins - pharmacology Rabbits Sympathetic Nervous System - physiology |
| title | Prostaglandins, antipyretic analgesics and adrenergic stimuli on the isolated artery |
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