A new cocktail for liquid scintillation counting of aqueous radioimmunoassay-samples
The aim of this investigation was to find a scintillation mixture for counting up to 1 ml of plasma. We succeeded in obtaining a mixture of xylene/Triton X-100/mono- and di-butylphosphate, and called it Plasmasol. The properties were ideal for radioimmunoassays of steroids. Good dissolving propertie...
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| Veröffentlicht in: | Clin. Chim. Acta, v. 59, no. 3, pp. 347-356 v. 59, no. 3, pp. 347-356, 1975-03, Vol.59 (3), p.347-356 |
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| container_title | Clin. Chim. Acta, v. 59, no. 3, pp. 347-356 |
| container_volume | 59 |
| creator | Wiegman, T. Woldring, M.G. Pratt, J.J. |
| description | The aim of this investigation was to find a scintillation mixture for counting up to 1 ml of plasma. We succeeded in obtaining a mixture of xylene/Triton X-100/mono- and di-butylphosphate, and called it Plasmasol. The properties were ideal for radioimmunoassays of steroids. Good dissolving properties, high counting efficiency, absence of chemiluminescence and a good stability and reproducibility with respect to the disintegrations per minute were achieved. The cost was only 25% of the commercially available ready-to-use liquid scintillation mixtures, with which a comparison was made. |
| doi_str_mv | 10.1016/0009-8981(75)90010-8 |
| format | Article |
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Chim. Acta, v. 59, no. 3, pp. 347-356</title><addtitle>Clin Chim Acta</addtitle><description>The aim of this investigation was to find a scintillation mixture for counting up to 1 ml of plasma. We succeeded in obtaining a mixture of xylene/Triton X-100/mono- and di-butylphosphate, and called it Plasmasol. The properties were ideal for radioimmunoassays of steroids. Good dissolving properties, high counting efficiency, absence of chemiluminescence and a good stability and reproducibility with respect to the disintegrations per minute were achieved. The cost was only 25% of the commercially available ready-to-use liquid scintillation mixtures, with which a comparison was made.</description><subject>Blood</subject><subject>BLOOD PLASMA</subject><subject>Carbon Radioisotopes - analysis</subject><subject>Drug Stability</subject><subject>Evaluation Studies as Topic</subject><subject>Indicators and Reagents</subject><subject>LIQUID SCINTILLATION DETECTORS-- PERFORMANCE</subject><subject>MIXTURES</subject><subject>N46110 --Instrumentation--Radiation Detection Instruments-- General Detectors & Monitors</subject><subject>Organophosphorus Compounds</subject><subject>Polyethylene Glycols</subject><subject>RADIOIMMUNOASSAY</subject><subject>Solubility</subject><subject>Steroids - analysis</subject><subject>Testosterone - analysis</subject><subject>Tritium - analysis</subject><subject>Xylenes</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-A4XiQfRQnaRpm1yEZfELBC96DmmaarRNdpNW8d-b2kVvnsIwz0zeeRA6wnCBAReXAMBTxhk-K_NzDoAhZVtohlmZpRnlZBvNfpE9tB_CWywpFHgX7WJMCiB4hp4WidWfiXLqvZemTRrnk9asB1MnQRnbm7aVvXE2EkOs7EvimkSuB-2GkHhZG2e6brBOhiC_0iC7VavDAdppZBv04eado-eb66flXfrweHu_XDykKmO0T7mssOJ1owinjFNeVFBBIUtVySJjBGijs5oWKtO8aBqW04rSnJV5XoICyWg2RyfTXhd6I2LeXqtX5azVqhcUl5wQHqHTCVp5F3OHXnQmKB3vsuMRghEGhGIcQTqByrsQvG7EyptO-i-BQYzGxahTjDpFmYsf44LFsePN_qHqdP03NCmO_aupr6OJD6P9GFRbpWvjx5y1M_9_8A22LY_C</recordid><startdate>19750324</startdate><enddate>19750324</enddate><creator>Wiegman, T.</creator><creator>Woldring, M.G.</creator><creator>Pratt, J.J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19750324</creationdate><title>A new cocktail for liquid scintillation counting of aqueous radioimmunoassay-samples</title><author>Wiegman, T. ; Woldring, M.G. ; Pratt, J.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-9ab1c9dfc29489496b0b06a7cba638204fe3d46c3e96ff854b445875570c0a843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Blood</topic><topic>BLOOD PLASMA</topic><topic>Carbon Radioisotopes - analysis</topic><topic>Drug Stability</topic><topic>Evaluation Studies as Topic</topic><topic>Indicators and Reagents</topic><topic>LIQUID SCINTILLATION DETECTORS-- PERFORMANCE</topic><topic>MIXTURES</topic><topic>N46110 --Instrumentation--Radiation Detection Instruments-- General Detectors & Monitors</topic><topic>Organophosphorus Compounds</topic><topic>Polyethylene Glycols</topic><topic>RADIOIMMUNOASSAY</topic><topic>Solubility</topic><topic>Steroids - analysis</topic><topic>Testosterone - analysis</topic><topic>Tritium - analysis</topic><topic>Xylenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiegman, T.</creatorcontrib><creatorcontrib>Woldring, M.G.</creatorcontrib><creatorcontrib>Pratt, J.J.</creatorcontrib><creatorcontrib>Rijksuniversiteit, Groningen, Netherlands</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Clin. 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The properties were ideal for radioimmunoassays of steroids. Good dissolving properties, high counting efficiency, absence of chemiluminescence and a good stability and reproducibility with respect to the disintegrations per minute were achieved. The cost was only 25% of the commercially available ready-to-use liquid scintillation mixtures, with which a comparison was made.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>1126021</pmid><doi>10.1016/0009-8981(75)90010-8</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-8981 |
| ispartof | Clin. Chim. Acta, v. 59, no. 3, pp. 347-356, 1975-03, Vol.59 (3), p.347-356 |
| issn | 0009-8981 1873-3492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82802411 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Blood BLOOD PLASMA Carbon Radioisotopes - analysis Drug Stability Evaluation Studies as Topic Indicators and Reagents LIQUID SCINTILLATION DETECTORS-- PERFORMANCE MIXTURES N46110 --Instrumentation--Radiation Detection Instruments-- General Detectors & Monitors Organophosphorus Compounds Polyethylene Glycols RADIOIMMUNOASSAY Solubility Steroids - analysis Testosterone - analysis Tritium - analysis Xylenes |
| title | A new cocktail for liquid scintillation counting of aqueous radioimmunoassay-samples |
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