Some Structural Requirements for Inhibition of Type A and B Forms of Rabbit Monoamine Oxidase by Tricyclic Psychoactive Drugs

We have determined the ability of several structurally related tricyclic antidepressant and tranquilizing drugs to inhibit both the type A form of monoamine oxidase (measured by 5-hydroxytryptamine deamination) and the type B form of the enzyme [measured by β-phenylethylamine (PEA) deamination] of r...

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Veröffentlicht in:	Molecular pharmacology 1975-01, Vol.11 (1), p.28-35
Hauptverfasser:	ROTH, JEROME A., GILLIS, C.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Brain - ultrastructure Deamination In Vitro Techniques Kinetics Male Mitochondria - enzymology Monoamine Oxidase Inhibitors - pharmacology Phenethylamines - metabolism Rabbits Serotonin - metabolism Structure-Activity Relationship Tranquilizing Agents - pharmacology Tyramine - metabolism
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