A selective inhibitor of the elicitation of immune-mediated reactions
6-Chloro-17a-hydroxypregna-1,4,6-triene-3,20-dione (CHP), a steroid having a progestin-type structure yet not having progestational activity, was found to exhibit moderate anti-inflammatory activity in a number of conventional tests for corticoid potency (e.g., thymolytic, granuloma, carrageenin ede...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 1975, Vol.55 (1), p.25-34 |
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| container_end_page | 34 |
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| container_title | Journal of allergy and clinical immunology |
| container_volume | 55 |
| creator | Ferraresi, Rodolfo W. Rooks, Wendell H. Nakano, Gayle M. Ringold, Howard J. Kidson, Chev |
| description | 6-Chloro-17a-hydroxypregna-1,4,6-triene-3,20-dione (CHP), a steroid having a progestin-type structure yet not having progestational activity, was found to exhibit moderate anti-inflammatory activity in a number of conventional tests for corticoid potency (e.g., thymolytic, granuloma, carrageenin edema). CHP was essentially equipotent, however, with cortisol in models of inflammation mediated via delayed hypersensitivity such as experimental allergic encephalomyelitis, adjuvant-induced arthritis, mouse skin graft, and mouse skin delayed hypersensitivity. In contrast to cortisol, which inhibits both 19-S and 7-S antibody formation, CHP does not diminish the number of cells producing either antibody. |
| doi_str_mv | 10.1016/S0091-6749(75)80005-4 |
| format | Article |
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CHP was essentially equipotent, however, with cortisol in models of inflammation mediated via delayed hypersensitivity such as experimental allergic encephalomyelitis, adjuvant-induced arthritis, mouse skin graft, and mouse skin delayed hypersensitivity. In contrast to cortisol, which inhibits both 19-S and 7-S antibody formation, CHP does not diminish the number of cells producing either antibody.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/S0091-6749(75)80005-4</identifier><identifier>PMID: 45926</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adrenal Glands - immunology ; Adrenalectomy ; Animals ; Anti-Inflammatory Agents - pharmacology ; Antibody-Producing Cells - drug effects ; Arthritis - drug therapy ; Arthritis - prevention & control ; Chlormadinone Acetate - analogs & derivatives ; Chlormadinone Acetate - pharmacology ; Edema - prevention & control ; Encephalomyelitis, Autoimmune, Experimental - prevention & control ; Female ; Humans ; Hydrocortisone - pharmacology ; Hypersensitivity, Delayed - immunology ; Hypersensitivity, Delayed - prevention & control ; Mice ; Mice, Inbred BALB C ; Mice, Inbred DBA ; Mycobacterium - immunology ; Organ Size ; Passive Cutaneous Anaphylaxis ; Pregnatrienes - pharmacology ; Rats ; Rats, Inbred Lew ; Serum Albumin ; Skin Transplantation ; Spleen - immunology ; Thymus Gland - immunology ; Transplantation, Homologous</subject><ispartof>Journal of allergy and clinical immunology, 1975, Vol.55 (1), p.25-34</ispartof><rights>1975 The C. 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Mosby Company</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-d0121534f619f723c9f00c72e1e95166013d0e22225ff4367853c47165d69f4f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-6749(75)80005-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/45926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferraresi, Rodolfo W.</creatorcontrib><creatorcontrib>Rooks, Wendell H.</creatorcontrib><creatorcontrib>Nakano, Gayle M.</creatorcontrib><creatorcontrib>Ringold, Howard J.</creatorcontrib><creatorcontrib>Kidson, Chev</creatorcontrib><title>A selective inhibitor of the elicitation of immune-mediated reactions</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>6-Chloro-17a-hydroxypregna-1,4,6-triene-3,20-dione (CHP), a steroid having a progestin-type structure yet not having progestational activity, was found to exhibit moderate anti-inflammatory activity in a number of conventional tests for corticoid potency (e.g., thymolytic, granuloma, carrageenin edema). CHP was essentially equipotent, however, with cortisol in models of inflammation mediated via delayed hypersensitivity such as experimental allergic encephalomyelitis, adjuvant-induced arthritis, mouse skin graft, and mouse skin delayed hypersensitivity. In contrast to cortisol, which inhibits both 19-S and 7-S antibody formation, CHP does not diminish the number of cells producing either antibody.</description><subject>Adrenal Glands - immunology</subject><subject>Adrenalectomy</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antibody-Producing Cells - drug effects</subject><subject>Arthritis - drug therapy</subject><subject>Arthritis - prevention & control</subject><subject>Chlormadinone Acetate - analogs & derivatives</subject><subject>Chlormadinone Acetate - pharmacology</subject><subject>Edema - prevention & control</subject><subject>Encephalomyelitis, Autoimmune, Experimental - prevention & control</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - pharmacology</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Hypersensitivity, Delayed - prevention & control</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred DBA</subject><subject>Mycobacterium - immunology</subject><subject>Organ Size</subject><subject>Passive Cutaneous Anaphylaxis</subject><subject>Pregnatrienes - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Serum Albumin</subject><subject>Skin Transplantation</subject><subject>Spleen - immunology</subject><subject>Thymus Gland - immunology</subject><subject>Transplantation, Homologous</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoNYtFZ_gQh7Ej2sTnbzsTlJKfUDCh7Uc9hmJzSyHzXZFvz3ZtvSq3MZmPedGd6HkBsKDxSoePwAUDQVkqk7ye8LAOApOyFjCkqmosj4KRkfLefkIoTv6FF5oc7IiHGViTGZT5OANZrebTFx7cotXd_5pLNJv8IEa2dcX_aua4eRa5pNi2mDlSt7rBKPpRm0cElGtqwDXh36hHw9zz9nr-ni_eVtNl2khgHv0wpoRnnOrKDKyiw3ygIYmSFFxakQQPMKMIvFrWW5kAXPDZNU8Eooy2w-Ibf7u2vf_Www9LpxwWBdly12m6CLTCquQEYj3xuN70LwaPXau6b0v5qCHuDpHTw9kNGS6x08zeLe9eHBZhljHrd2tKL6tFcxZtw69DoYh62JPHxEqKvO_XP_D3VifOU</recordid><startdate>1975</startdate><enddate>1975</enddate><creator>Ferraresi, Rodolfo W.</creator><creator>Rooks, Wendell H.</creator><creator>Nakano, Gayle M.</creator><creator>Ringold, Howard J.</creator><creator>Kidson, Chev</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1975</creationdate><title>A selective inhibitor of the elicitation of immune-mediated reactions</title><author>Ferraresi, Rodolfo W. ; Rooks, Wendell H. ; Nakano, Gayle M. ; Ringold, Howard J. ; Kidson, Chev</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-d0121534f619f723c9f00c72e1e95166013d0e22225ff4367853c47165d69f4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adrenal Glands - immunology</topic><topic>Adrenalectomy</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antibody-Producing Cells - drug effects</topic><topic>Arthritis - drug therapy</topic><topic>Arthritis - prevention & control</topic><topic>Chlormadinone Acetate - analogs & derivatives</topic><topic>Chlormadinone Acetate - pharmacology</topic><topic>Edema - prevention & control</topic><topic>Encephalomyelitis, Autoimmune, Experimental - prevention & control</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - pharmacology</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Hypersensitivity, Delayed - prevention & control</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred DBA</topic><topic>Mycobacterium - immunology</topic><topic>Organ Size</topic><topic>Passive Cutaneous Anaphylaxis</topic><topic>Pregnatrienes - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Serum Albumin</topic><topic>Skin Transplantation</topic><topic>Spleen - immunology</topic><topic>Thymus Gland - immunology</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferraresi, Rodolfo W.</creatorcontrib><creatorcontrib>Rooks, Wendell H.</creatorcontrib><creatorcontrib>Nakano, Gayle M.</creatorcontrib><creatorcontrib>Ringold, Howard J.</creatorcontrib><creatorcontrib>Kidson, Chev</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferraresi, Rodolfo W.</au><au>Rooks, Wendell H.</au><au>Nakano, Gayle M.</au><au>Ringold, Howard J.</au><au>Kidson, Chev</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A selective inhibitor of the elicitation of immune-mediated reactions</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1975</date><risdate>1975</risdate><volume>55</volume><issue>1</issue><spage>25</spage><epage>34</epage><pages>25-34</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>6-Chloro-17a-hydroxypregna-1,4,6-triene-3,20-dione (CHP), a steroid having a progestin-type structure yet not having progestational activity, was found to exhibit moderate anti-inflammatory activity in a number of conventional tests for corticoid potency (e.g., thymolytic, granuloma, carrageenin edema). CHP was essentially equipotent, however, with cortisol in models of inflammation mediated via delayed hypersensitivity such as experimental allergic encephalomyelitis, adjuvant-induced arthritis, mouse skin graft, and mouse skin delayed hypersensitivity. In contrast to cortisol, which inhibits both 19-S and 7-S antibody formation, CHP does not diminish the number of cells producing either antibody.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>45926</pmid><doi>10.1016/S0091-6749(75)80005-4</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 1975, Vol.55 (1), p.25-34 |
| issn | 0091-6749 1097-6825 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82795907 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenal Glands - immunology Adrenalectomy Animals Anti-Inflammatory Agents - pharmacology Antibody-Producing Cells - drug effects Arthritis - drug therapy Arthritis - prevention & control Chlormadinone Acetate - analogs & derivatives Chlormadinone Acetate - pharmacology Edema - prevention & control Encephalomyelitis, Autoimmune, Experimental - prevention & control Female Humans Hydrocortisone - pharmacology Hypersensitivity, Delayed - immunology Hypersensitivity, Delayed - prevention & control Mice Mice, Inbred BALB C Mice, Inbred DBA Mycobacterium - immunology Organ Size Passive Cutaneous Anaphylaxis Pregnatrienes - pharmacology Rats Rats, Inbred Lew Serum Albumin Skin Transplantation Spleen - immunology Thymus Gland - immunology Transplantation, Homologous |
| title | A selective inhibitor of the elicitation of immune-mediated reactions |
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