Stability Study of Nitroglycerin Sublingual Tablets
Nitroglycerin sublingual tablets were studied over a 1‐year period to determine tablet stability in terms of loss of strength, uniformity of tablets, and degradation of the drug itself. Tablets from six different firms were analyzed by a semiautomated procedure. The samples included two molded table...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1975-01, Vol.64 (1), p.140-147 |
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| container_end_page | 147 |
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| container_issue | 1 |
| container_start_page | 140 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 64 |
| creator | Page, Donald P. Carson, N. Aubrey Buhr, Clarence A. Flinn, Paul E. Wells, Clyde E. Randall, Margaret T. |
| description | Nitroglycerin sublingual tablets were studied over a 1‐year period to determine tablet stability in terms of loss of strength, uniformity of tablets, and degradation of the drug itself. Tablets from six different firms were analyzed by a semiautomated procedure. The samples included two molded tablets and four compressed tablets, ranging in age at the time of initial assay from 40 days to over 1 year. The results indicated that there is a loss of strength of nitroglycerin tablets and that refrigeration slows down this loss. The study also indicated that these tablets were stable during the year of testing in terms of tablet uniformity and degradation of nitroglycerin. |
| doi_str_mv | 10.1002/jps.2600640133 |
| format | Article |
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Aubrey ; Buhr, Clarence A. ; Flinn, Paul E. ; Wells, Clyde E. ; Randall, Margaret T.</creator><creatorcontrib>Page, Donald P. ; Carson, N. Aubrey ; Buhr, Clarence A. ; Flinn, Paul E. ; Wells, Clyde E. ; Randall, Margaret T.</creatorcontrib><description>Nitroglycerin sublingual tablets were studied over a 1‐year period to determine tablet stability in terms of loss of strength, uniformity of tablets, and degradation of the drug itself. Tablets from six different firms were analyzed by a semiautomated procedure. The samples included two molded tablets and four compressed tablets, ranging in age at the time of initial assay from 40 days to over 1 year. The results indicated that there is a loss of strength of nitroglycerin tablets and that refrigeration slows down this loss. The study also indicated that these tablets were stable during the year of testing in terms of tablet uniformity and degradation of nitroglycerin.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600640133</identifier><identifier>PMID: 805832</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Analysis of Variance ; and degradation of drug ; Aniline Compounds - analysis ; Autoanalysis - instrumentation ; Chromatography, Thin Layer ; Colorimetry - instrumentation ; Content uniformity-nitroglycerin sublingual tablets ; Drug Packaging ; Drug Stability ; Indicators and Reagents ; Kinetics ; loss of strength ; Methods ; Nitroglycerin ; Nitroglycerin sublingual tablets-stability study ; Nitroglycerin sublingual tablets—stability study, loss of strength, uniformity of tablets, and degradation of drug ; Stability-nitroglycerin sublingual tablets ; Stability—nitroglycerin sublingual tablets, loss of strength, uniformity of tablets, and degradation of drug ; sublingual nitroglycerin-stability ; Tablets ; Tablets, sublingual nitroglycerin—stability ; uniformity of tablets</subject><ispartof>Journal of pharmaceutical sciences, 1975-01, Vol.64 (1), p.140-147</ispartof><rights>1975 Wiley‐Liss, Inc., A Wiley Company</rights><rights>Copyright © 1975 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4263-79400dafe1f29cdf9d7ae0bb48d4c66c2ead53657899025b6c563a6e100fa0753</citedby><cites>FETCH-LOGICAL-c4263-79400dafe1f29cdf9d7ae0bb48d4c66c2ead53657899025b6c563a6e100fa0753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600640133$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600640133$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/805832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Page, Donald P.</creatorcontrib><creatorcontrib>Carson, N. Aubrey</creatorcontrib><creatorcontrib>Buhr, Clarence A.</creatorcontrib><creatorcontrib>Flinn, Paul E.</creatorcontrib><creatorcontrib>Wells, Clyde E.</creatorcontrib><creatorcontrib>Randall, Margaret T.</creatorcontrib><title>Stability Study of Nitroglycerin Sublingual Tablets</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Nitroglycerin sublingual tablets were studied over a 1‐year period to determine tablet stability in terms of loss of strength, uniformity of tablets, and degradation of the drug itself. Tablets from six different firms were analyzed by a semiautomated procedure. The samples included two molded tablets and four compressed tablets, ranging in age at the time of initial assay from 40 days to over 1 year. The results indicated that there is a loss of strength of nitroglycerin tablets and that refrigeration slows down this loss. The study also indicated that these tablets were stable during the year of testing in terms of tablet uniformity and degradation of nitroglycerin.</description><subject>Analysis of Variance</subject><subject>and degradation of drug</subject><subject>Aniline Compounds - analysis</subject><subject>Autoanalysis - instrumentation</subject><subject>Chromatography, Thin Layer</subject><subject>Colorimetry - instrumentation</subject><subject>Content uniformity-nitroglycerin sublingual tablets</subject><subject>Drug Packaging</subject><subject>Drug Stability</subject><subject>Indicators and Reagents</subject><subject>Kinetics</subject><subject>loss of strength</subject><subject>Methods</subject><subject>Nitroglycerin</subject><subject>Nitroglycerin sublingual tablets-stability study</subject><subject>Nitroglycerin sublingual tablets—stability study, loss of strength, uniformity of tablets, and degradation of drug</subject><subject>Stability-nitroglycerin sublingual tablets</subject><subject>Stability—nitroglycerin sublingual tablets, loss of strength, uniformity of tablets, and degradation of drug</subject><subject>sublingual nitroglycerin-stability</subject><subject>Tablets</subject><subject>Tablets, sublingual nitroglycerin—stability</subject><subject>uniformity of tablets</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFP3DAQhS1UShfKlVMPOXHLMrFjOz5WK6BQBEi7iKPl2BNk6t1s7aRt_j1BWVH1UHGaw_vek-Yj5KSAeQFAz563aU4FgCihYGyPzApOIRdQyA9kNgI0Z7xUn8hhSs8wYsD5AflYAa8YnRG27Eztg--GbNn1bsjaJrv1XWyfwmAx-k227OvgN0-9CdnK1AG79JnsNyYkPN7dI_Jwcb5afMtv7i6vFl9vcltSwXKpSgBnGiwaqqxrlJMGoa7LypVWCEvROM4El5VSQHktLBfMCBy_agxIzo7I6bS7je3PHlOn1z5ZDMFssO2TrqiUitFXcD6BNrYpRWz0Nvq1iYMuQL9K0qMk_VfSWPiyW-7rNbo3fLIyxmqKf_uAwztj-vp--c90PnV96vDPW9fEH1pIJrl-vL3UC0aL74o96ouRryYeR5O_PEadrMeNRecj2k671v_vixfSgZPT</recordid><startdate>197501</startdate><enddate>197501</enddate><creator>Page, Donald P.</creator><creator>Carson, N. Aubrey</creator><creator>Buhr, Clarence A.</creator><creator>Flinn, Paul E.</creator><creator>Wells, Clyde E.</creator><creator>Randall, Margaret T.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197501</creationdate><title>Stability Study of Nitroglycerin Sublingual Tablets</title><author>Page, Donald P. ; Carson, N. Aubrey ; Buhr, Clarence A. ; Flinn, Paul E. ; Wells, Clyde E. ; Randall, Margaret T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4263-79400dafe1f29cdf9d7ae0bb48d4c66c2ead53657899025b6c563a6e100fa0753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Analysis of Variance</topic><topic>and degradation of drug</topic><topic>Aniline Compounds - analysis</topic><topic>Autoanalysis - instrumentation</topic><topic>Chromatography, Thin Layer</topic><topic>Colorimetry - instrumentation</topic><topic>Content uniformity-nitroglycerin sublingual tablets</topic><topic>Drug Packaging</topic><topic>Drug Stability</topic><topic>Indicators and Reagents</topic><topic>Kinetics</topic><topic>loss of strength</topic><topic>Methods</topic><topic>Nitroglycerin</topic><topic>Nitroglycerin sublingual tablets-stability study</topic><topic>Nitroglycerin sublingual tablets—stability study, loss of strength, uniformity of tablets, and degradation of drug</topic><topic>Stability-nitroglycerin sublingual tablets</topic><topic>Stability—nitroglycerin sublingual tablets, loss of strength, uniformity of tablets, and degradation of drug</topic><topic>sublingual nitroglycerin-stability</topic><topic>Tablets</topic><topic>Tablets, sublingual nitroglycerin—stability</topic><topic>uniformity of tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Page, Donald P.</creatorcontrib><creatorcontrib>Carson, N. Aubrey</creatorcontrib><creatorcontrib>Buhr, Clarence A.</creatorcontrib><creatorcontrib>Flinn, Paul E.</creatorcontrib><creatorcontrib>Wells, Clyde E.</creatorcontrib><creatorcontrib>Randall, Margaret T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Page, Donald P.</au><au>Carson, N. Aubrey</au><au>Buhr, Clarence A.</au><au>Flinn, Paul E.</au><au>Wells, Clyde E.</au><au>Randall, Margaret T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stability Study of Nitroglycerin Sublingual Tablets</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1975-01</date><risdate>1975</risdate><volume>64</volume><issue>1</issue><spage>140</spage><epage>147</epage><pages>140-147</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Nitroglycerin sublingual tablets were studied over a 1‐year period to determine tablet stability in terms of loss of strength, uniformity of tablets, and degradation of the drug itself. Tablets from six different firms were analyzed by a semiautomated procedure. The samples included two molded tablets and four compressed tablets, ranging in age at the time of initial assay from 40 days to over 1 year. The results indicated that there is a loss of strength of nitroglycerin tablets and that refrigeration slows down this loss. The study also indicated that these tablets were stable during the year of testing in terms of tablet uniformity and degradation of nitroglycerin.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>805832</pmid><doi>10.1002/jps.2600640133</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1975-01, Vol.64 (1), p.140-147 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Analysis of Variance and degradation of drug Aniline Compounds - analysis Autoanalysis - instrumentation Chromatography, Thin Layer Colorimetry - instrumentation Content uniformity-nitroglycerin sublingual tablets Drug Packaging Drug Stability Indicators and Reagents Kinetics loss of strength Methods Nitroglycerin Nitroglycerin sublingual tablets-stability study Nitroglycerin sublingual tablets—stability study, loss of strength, uniformity of tablets, and degradation of drug Stability-nitroglycerin sublingual tablets Stability—nitroglycerin sublingual tablets, loss of strength, uniformity of tablets, and degradation of drug sublingual nitroglycerin-stability Tablets Tablets, sublingual nitroglycerin—stability uniformity of tablets |
| title | Stability Study of Nitroglycerin Sublingual Tablets |
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