Histamine and microcirculation
Recent research of histamine metabolism suggests that microvascular smooth muscle and endothelial cells are under the continuous dilator influence of minute quantities of intrinsically formed histamine, produced by action of an inducible form of histidine decarboxylase. Various autonomous dilator ac...
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| Veröffentlicht in: | Life Sciences 1974-08, Vol.15 (3), p.391-401 |
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| container_title | Life Sciences |
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| creator | Schayer, Richard W. |
| description | Recent research of histamine metabolism suggests that microvascular smooth muscle and endothelial cells are under the continuous dilator influence of minute quantities of intrinsically formed histamine, produced by action of an inducible form of histidine decarboxylase. Various autonomous dilator activities of the microcirculation, e.g., vasomotion, reactive and post- exercise hyperemia and autoregulation, may all involve interplay of this intrinsic dilator with an intrinsic constictor mechanism. Drastic stimuli which cause a marked increase in histamine output locally or systemically, may lead to the early, slowly-developing microvascular changes in inflammation and shock, respectively. |
| doi_str_mv | 10.1016/0024-3205(74)90338-5 |
| format | Article |
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Various autonomous dilator activities of the microcirculation, e.g., vasomotion, reactive and post- exercise hyperemia and autoregulation, may all involve interplay of this intrinsic dilator with an intrinsic constictor mechanism. Drastic stimuli which cause a marked increase in histamine output locally or systemically, may lead to the early, slowly-developing microvascular changes in inflammation and shock, respectively.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(74)90338-5</identifier><identifier>PMID: 4620963</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Catecholamines - physiology ; Exercise ; Histamine - physiology ; Histidine Decarboxylase - metabolism ; Homeostasis ; Humans ; Hyperemia - physiopathology ; Microcirculation ; Protein Biosynthesis ; Vasodilation</subject><ispartof>Life Sciences, 1974-08, Vol.15 (3), p.391-401</ispartof><rights>1974</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-c42697b18a16306ae3b4606bb38bdc7852e61bbcf375b6778ed3460fe73ed18f3</citedby><cites>FETCH-LOGICAL-c357t-c42697b18a16306ae3b4606bb38bdc7852e61bbcf375b6778ed3460fe73ed18f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0024320574903385$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,776,780,788,3536,27901,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4620963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schayer, Richard W.</creatorcontrib><title>Histamine and microcirculation</title><title>Life Sciences</title><addtitle>Life Sci</addtitle><description>Recent research of histamine metabolism suggests that microvascular smooth muscle and endothelial cells are under the continuous dilator influence of minute quantities of intrinsically formed histamine, produced by action of an inducible form of histidine decarboxylase. Various autonomous dilator activities of the microcirculation, e.g., vasomotion, reactive and post- exercise hyperemia and autoregulation, may all involve interplay of this intrinsic dilator with an intrinsic constictor mechanism. Drastic stimuli which cause a marked increase in histamine output locally or systemically, may lead to the early, slowly-developing microvascular changes in inflammation and shock, respectively.</description><subject>Animals</subject><subject>Catecholamines - physiology</subject><subject>Exercise</subject><subject>Histamine - physiology</subject><subject>Histidine Decarboxylase - metabolism</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hyperemia - physiopathology</subject><subject>Microcirculation</subject><subject>Protein Biosynthesis</subject><subject>Vasodilation</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LAzEQxYMotVb_A5WeRA-rk83nXgpS1AoFL3oOSXYWIvtRk13B_96tLT16msP83pt5j5BLCvcUqHwAyHnGchC3it8VwJjOxBGZUq2KDCSjx2R6QE7JWUqfACCEYhMy4TKHQrIpuV6F1NsmtDi3bTlvgo-dD9EPte1D156Tk8rWCS_2c0Y-np_el6ts_fbyunxcZ54J1Wee57JQjmpLJQNpkTkuQTrHtCu90iJHSZ3zFVPCSaU0lmwEKlQMS6orNiM3O99N7L4GTL1pQvJY17bFbkhG50pqUHwE-Q4c_0wpYmU2MTQ2_hgKZluL2WY228xGcfNXixGj7GrvP7gGy4No38O4X-z2OIb8DhhN8gFbj2WI6HtTduH_A7_q32-Z</recordid><startdate>19740801</startdate><enddate>19740801</enddate><creator>Schayer, Richard W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19740801</creationdate><title>Histamine and microcirculation</title><author>Schayer, Richard W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-c42697b18a16306ae3b4606bb38bdc7852e61bbcf375b6778ed3460fe73ed18f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Animals</topic><topic>Catecholamines - physiology</topic><topic>Exercise</topic><topic>Histamine - physiology</topic><topic>Histidine Decarboxylase - metabolism</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hyperemia - physiopathology</topic><topic>Microcirculation</topic><topic>Protein Biosynthesis</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schayer, Richard W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schayer, Richard W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histamine and microcirculation</atitle><jtitle>Life Sciences</jtitle><addtitle>Life Sci</addtitle><date>1974-08-01</date><risdate>1974</risdate><volume>15</volume><issue>3</issue><spage>391</spage><epage>401</epage><pages>391-401</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Recent research of histamine metabolism suggests that microvascular smooth muscle and endothelial cells are under the continuous dilator influence of minute quantities of intrinsically formed histamine, produced by action of an inducible form of histidine decarboxylase. 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| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life Sciences, 1974-08, Vol.15 (3), p.391-401 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Catecholamines - physiology Exercise Histamine - physiology Histidine Decarboxylase - metabolism Homeostasis Humans Hyperemia - physiopathology Microcirculation Protein Biosynthesis Vasodilation |
| title | Histamine and microcirculation |
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