RENIN STIMULATION CAUSED BY BLOOD COLLECTION TECHNIQUES IN THE RAT
SUMMARY 1. Experiments were conducted in rats to determine the effects of various methods of blood collection upon plasma renin concentration (PRC). 2. Either restraint or anaesthesia during blood sampling resulted in PRC levels up to five times higher than in samples collected after decapitation. 3...
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| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 1974-12, Vol.1 (6), p.495-501 |
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| container_title | Clinical and experimental pharmacology & physiology |
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| creator | Oates, Helen F. Stokes, Gordon S. |
| description | SUMMARY 1. Experiments were conducted in rats to determine the effects of various methods of blood collection upon plasma renin concentration (PRC).
2. Either restraint or anaesthesia during blood sampling resulted in PRC levels up to five times higher than in samples collected after decapitation.
3. A similar difference was observed in adrenalectomized rats, indicating that the PRC increase did not depend upon liberation of adrenal catecholamines.
4. In contrast, administration of propranolol abolished the difference in PRC between decapitated rats, and those sampled during ether anaesthesia, suggesting involvement of a β‐adrenoreceptor mechanism in the stimulation of renin release by anaesthesia.
5. Despite high starting levels of PRC in ether‐anaesthetized rats, the PRC response to water deprivation was proportionally the same (a 7‐fold increase), whether sampling was carried out during ether anaesthesia or after decapitation. |
| doi_str_mv | 10.1111/j.1440-1681.1974.tb00570.x |
| format | Article |
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2. Either restraint or anaesthesia during blood sampling resulted in PRC levels up to five times higher than in samples collected after decapitation.
3. A similar difference was observed in adrenalectomized rats, indicating that the PRC increase did not depend upon liberation of adrenal catecholamines.
4. In contrast, administration of propranolol abolished the difference in PRC between decapitated rats, and those sampled during ether anaesthesia, suggesting involvement of a β‐adrenoreceptor mechanism in the stimulation of renin release by anaesthesia.
5. Despite high starting levels of PRC in ether‐anaesthetized rats, the PRC response to water deprivation was proportionally the same (a 7‐fold increase), whether sampling was carried out during ether anaesthesia or after decapitation.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/j.1440-1681.1974.tb00570.x</identifier><identifier>PMID: 4461179</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adrenal Glands - physiology ; anaesthetized rat ; Animals ; Blood Specimen Collection ; conscious rat ; decapitated rat ; Hypertension, Renal - blood ; plasma renin concentration ; Propranolol - pharmacology ; Rats ; Renin - blood ; Water Deprivation ; β-adrenoreceptor blockade</subject><ispartof>Clinical and experimental pharmacology & physiology, 1974-12, Vol.1 (6), p.495-501</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4075-93cae9642ed060a97ec5c0693948bf822d77336f73dde4fe5b7b3a19048d45283</citedby><cites>FETCH-LOGICAL-c4075-93cae9642ed060a97ec5c0693948bf822d77336f73dde4fe5b7b3a19048d45283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1681.1974.tb00570.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1681.1974.tb00570.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4461179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oates, Helen F.</creatorcontrib><creatorcontrib>Stokes, Gordon S.</creatorcontrib><title>RENIN STIMULATION CAUSED BY BLOOD COLLECTION TECHNIQUES IN THE RAT</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY 1. Experiments were conducted in rats to determine the effects of various methods of blood collection upon plasma renin concentration (PRC).
2. Either restraint or anaesthesia during blood sampling resulted in PRC levels up to five times higher than in samples collected after decapitation.
3. A similar difference was observed in adrenalectomized rats, indicating that the PRC increase did not depend upon liberation of adrenal catecholamines.
4. In contrast, administration of propranolol abolished the difference in PRC between decapitated rats, and those sampled during ether anaesthesia, suggesting involvement of a β‐adrenoreceptor mechanism in the stimulation of renin release by anaesthesia.
5. Despite high starting levels of PRC in ether‐anaesthetized rats, the PRC response to water deprivation was proportionally the same (a 7‐fold increase), whether sampling was carried out during ether anaesthesia or after decapitation.</description><subject>Adrenal Glands - physiology</subject><subject>anaesthetized rat</subject><subject>Animals</subject><subject>Blood Specimen Collection</subject><subject>conscious rat</subject><subject>decapitated rat</subject><subject>Hypertension, Renal - blood</subject><subject>plasma renin concentration</subject><subject>Propranolol - pharmacology</subject><subject>Rats</subject><subject>Renin - blood</subject><subject>Water Deprivation</subject><subject>β-adrenoreceptor blockade</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtPwkAYRSdGo_j4CSaNC3et33ReHRcmUIo0qa1CiXE16WOagCDYgQj_3mIJe2czi3vvmcxB6A6Dg5vzMHMwpWBj7mEHS0GddQ7ABDjbE9Q5RqeoAwSYjT0BF-jSmBk0LeDkHJ1TyjEWsoN6oyAOY2uchi-TqJuGSWz53ck46Fu9D6sXJUnf8pMoCvy_KA38YRy-TYKx1YzSYWCNuuk1OquyudE3h_sKTQZB6g_tKHkO_W5kFxQEsyUpMi05dXUJHDIpdMEK4JJI6uWV57qlEITwSpCy1LTSLBc5ybAE6pWUuR65Qvctd1UvvzfarNViago9n2dferkxynMFZ83HmuJjWyzqpTG1rtSqni6yeqcwqL1ANVN7S2pvSe0FqoNAtW3Gt4dXNvlCl8fpwViTP7X5z3Sud_8gKz94pZI1ALsFTM1ab4-ArP5UXBDB1Hv8rMiADN56L6BG5Bf7yYe-</recordid><startdate>197412</startdate><enddate>197412</enddate><creator>Oates, Helen F.</creator><creator>Stokes, Gordon S.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197412</creationdate><title>RENIN STIMULATION CAUSED BY BLOOD COLLECTION TECHNIQUES IN THE RAT</title><author>Oates, Helen F. ; Stokes, Gordon S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4075-93cae9642ed060a97ec5c0693948bf822d77336f73dde4fe5b7b3a19048d45283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Adrenal Glands - physiology</topic><topic>anaesthetized rat</topic><topic>Animals</topic><topic>Blood Specimen Collection</topic><topic>conscious rat</topic><topic>decapitated rat</topic><topic>Hypertension, Renal - blood</topic><topic>plasma renin concentration</topic><topic>Propranolol - pharmacology</topic><topic>Rats</topic><topic>Renin - blood</topic><topic>Water Deprivation</topic><topic>β-adrenoreceptor blockade</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oates, Helen F.</creatorcontrib><creatorcontrib>Stokes, Gordon S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oates, Helen F.</au><au>Stokes, Gordon S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RENIN STIMULATION CAUSED BY BLOOD COLLECTION TECHNIQUES IN THE RAT</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>1974-12</date><risdate>1974</risdate><volume>1</volume><issue>6</issue><spage>495</spage><epage>501</epage><pages>495-501</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY 1. Experiments were conducted in rats to determine the effects of various methods of blood collection upon plasma renin concentration (PRC).
2. Either restraint or anaesthesia during blood sampling resulted in PRC levels up to five times higher than in samples collected after decapitation.
3. A similar difference was observed in adrenalectomized rats, indicating that the PRC increase did not depend upon liberation of adrenal catecholamines.
4. In contrast, administration of propranolol abolished the difference in PRC between decapitated rats, and those sampled during ether anaesthesia, suggesting involvement of a β‐adrenoreceptor mechanism in the stimulation of renin release by anaesthesia.
5. Despite high starting levels of PRC in ether‐anaesthetized rats, the PRC response to water deprivation was proportionally the same (a 7‐fold increase), whether sampling was carried out during ether anaesthesia or after decapitation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>4461179</pmid><doi>10.1111/j.1440-1681.1974.tb00570.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical and experimental pharmacology & physiology, 1974-12, Vol.1 (6), p.495-501 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adrenal Glands - physiology anaesthetized rat Animals Blood Specimen Collection conscious rat decapitated rat Hypertension, Renal - blood plasma renin concentration Propranolol - pharmacology Rats Renin - blood Water Deprivation β-adrenoreceptor blockade |
| title | RENIN STIMULATION CAUSED BY BLOOD COLLECTION TECHNIQUES IN THE RAT |
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