Arginine Vasotocin: Effects on Development of Reproductive Organs
Immature 25-day-old mice were injected daily with 1 microgram of arginine vasotocin for 3 or 4 days and killed 24 hours after the last injection. The ovaries were 30 percent smaller in treated females than in controls. The ventral prostates and accessory organs (seminal vesicles and coagulating glan...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1974-12, Vol.186 (4167), p.938-939 |
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| container_issue | 4167 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Vaughan, Mary K. Vaughan, George M. Klein, David C. |
| description | Immature 25-day-old mice were injected daily with 1 microgram of arginine vasotocin for 3 or 4 days and killed 24 hours after the last injection. The ovaries were 30 percent smaller in treated females than in controls. The ventral prostates and accessory organs (seminal vesicles and coagulating glands) were less than half the size of these structures in control males. Similar results were observed when 15-day-old mice were given similar injections and killed 2 weeks after the last injection; furthermore, testis weights were 28 percent smaller than those of controls. It is speculated that arginine vasotocin, which has been found in mammalian pineal glands, might mediate effects of the pineal gland on normal sexual development. |
| doi_str_mv | 10.1126/science.186.4167.938 |
| format | Article |
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The ovaries were 30 percent smaller in treated females than in controls. The ventral prostates and accessory organs (seminal vesicles and coagulating glands) were less than half the size of these structures in control males. Similar results were observed when 15-day-old mice were given similar injections and killed 2 weeks after the last injection; furthermore, testis weights were 28 percent smaller than those of controls. It is speculated that arginine vasotocin, which has been found in mammalian pineal glands, might mediate effects of the pineal gland on normal sexual development.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.186.4167.938</identifier><identifier>PMID: 4469691</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Age Factors ; Animals ; Body Weight - drug effects ; Cholecalciferols ; Female ; Female animals ; Genitalia - drug effects ; Genitalia - growth & development ; Human organs ; Immatures ; Male ; Male animals ; Mathematical rings ; Mice ; Organ Size - drug effects ; Ovaries ; Ovary - drug effects ; Pediatrics ; Pineal gland ; Prostate - drug effects ; Sexual development ; Testis - drug effects ; Uterus - drug effects ; Vasotocin - pharmacology</subject><ispartof>Science (American Association for the Advancement of Science), 1974-12, Vol.186 (4167), p.938-939</ispartof><rights>Copyright 1974 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-819509f5debc21113d32a87f53965952d50ad893b87c6705c97960bfb22a08043</citedby><cites>FETCH-LOGICAL-c353t-819509f5debc21113d32a87f53965952d50ad893b87c6705c97960bfb22a08043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1739539$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1739539$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4469691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaughan, Mary K.</creatorcontrib><creatorcontrib>Vaughan, George M.</creatorcontrib><creatorcontrib>Klein, David C.</creatorcontrib><title>Arginine Vasotocin: Effects on Development of Reproductive Organs</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Immature 25-day-old mice were injected daily with 1 microgram of arginine vasotocin for 3 or 4 days and killed 24 hours after the last injection. The ovaries were 30 percent smaller in treated females than in controls. The ventral prostates and accessory organs (seminal vesicles and coagulating glands) were less than half the size of these structures in control males. Similar results were observed when 15-day-old mice were given similar injections and killed 2 weeks after the last injection; furthermore, testis weights were 28 percent smaller than those of controls. It is speculated that arginine vasotocin, which has been found in mammalian pineal glands, might mediate effects of the pineal gland on normal sexual development.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Cholecalciferols</subject><subject>Female</subject><subject>Female animals</subject><subject>Genitalia - drug effects</subject><subject>Genitalia - growth & development</subject><subject>Human organs</subject><subject>Immatures</subject><subject>Male</subject><subject>Male animals</subject><subject>Mathematical rings</subject><subject>Mice</subject><subject>Organ Size - drug effects</subject><subject>Ovaries</subject><subject>Ovary - drug effects</subject><subject>Pediatrics</subject><subject>Pineal gland</subject><subject>Prostate - drug effects</subject><subject>Sexual development</subject><subject>Testis - drug effects</subject><subject>Uterus - drug effects</subject><subject>Vasotocin - pharmacology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwzAQhC0EKqXwD4qUE7cUP-IXtwrKQ6pUCQFXy3HsKlUSFzupxL_HVSM47WF2Znc-AOYILhDC7D6a2nbGLpBgiwIxvpBEnIEpgpLmEkNyDqYQEpYLyOkluIpxB2HSJJmASVEwySSaguUybOuu7mz2paPvvam7h2zlnDV9zHyXPdmDbfy-tV2feZe9233w1WD6-mCzTdjqLl6DC6ebaG_GOQOfz6uPx9d8vXl5e1yuc0Mo6XOBJIXS0cqWBiOESEWwFtxRIhmVFFcU6kpIUgpuGIfUSC4ZLF2JsYYCFmQG7k656YPvwcZetXU0tml0Z_0QlcCcSpZuzUBxWjTBxxisU_tQtzr8KATVkZwayalETh3JqUQu2W7H_KFsbfVnGlElfX7Sd7H34T-TE5k6kF8mt3Pe</recordid><startdate>19741206</startdate><enddate>19741206</enddate><creator>Vaughan, Mary K.</creator><creator>Vaughan, George M.</creator><creator>Klein, David C.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19741206</creationdate><title>Arginine Vasotocin: Effects on Development of Reproductive Organs</title><author>Vaughan, Mary K. ; Vaughan, George M. ; Klein, David C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-819509f5debc21113d32a87f53965952d50ad893b87c6705c97960bfb22a08043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Cholecalciferols</topic><topic>Female</topic><topic>Female animals</topic><topic>Genitalia - drug effects</topic><topic>Genitalia - growth & development</topic><topic>Human organs</topic><topic>Immatures</topic><topic>Male</topic><topic>Male animals</topic><topic>Mathematical rings</topic><topic>Mice</topic><topic>Organ Size - drug effects</topic><topic>Ovaries</topic><topic>Ovary - drug effects</topic><topic>Pediatrics</topic><topic>Pineal gland</topic><topic>Prostate - drug effects</topic><topic>Sexual development</topic><topic>Testis - drug effects</topic><topic>Uterus - drug effects</topic><topic>Vasotocin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaughan, Mary K.</creatorcontrib><creatorcontrib>Vaughan, George M.</creatorcontrib><creatorcontrib>Klein, David C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaughan, Mary K.</au><au>Vaughan, George M.</au><au>Klein, David C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arginine Vasotocin: Effects on Development of Reproductive Organs</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1974-12-06</date><risdate>1974</risdate><volume>186</volume><issue>4167</issue><spage>938</spage><epage>939</epage><pages>938-939</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Immature 25-day-old mice were injected daily with 1 microgram of arginine vasotocin for 3 or 4 days and killed 24 hours after the last injection. The ovaries were 30 percent smaller in treated females than in controls. The ventral prostates and accessory organs (seminal vesicles and coagulating glands) were less than half the size of these structures in control males. Similar results were observed when 15-day-old mice were given similar injections and killed 2 weeks after the last injection; furthermore, testis weights were 28 percent smaller than those of controls. It is speculated that arginine vasotocin, which has been found in mammalian pineal glands, might mediate effects of the pineal gland on normal sexual development.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>4469691</pmid><doi>10.1126/science.186.4167.938</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1974-12, Vol.186 (4167), p.938-939 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82759635 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Age Factors Animals Body Weight - drug effects Cholecalciferols Female Female animals Genitalia - drug effects Genitalia - growth & development Human organs Immatures Male Male animals Mathematical rings Mice Organ Size - drug effects Ovaries Ovary - drug effects Pediatrics Pineal gland Prostate - drug effects Sexual development Testis - drug effects Uterus - drug effects Vasotocin - pharmacology |
| title | Arginine Vasotocin: Effects on Development of Reproductive Organs |
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