Supravital Blood Studies, Using Acridine Orange Fluorescence
A simple method for supravital fluorochroming of blood with acridine orange has been described. The supravital method is of value in distinguishing nucleated cellular elements, reticulocytes and erythrocytic inclusions. Preliminary studies of peripheral blood in leukemia indicate that it may be help...
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| Veröffentlicht in: | Blood 1961-05, Vol.17 (5), p.643-649 |
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| container_title | Blood |
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| creator | Jackson, John F. |
| description | A simple method for supravital fluorochroming of blood with acridine orange has been described. The supravital method is of value in distinguishing nucleated cellular elements, reticulocytes and erythrocytic inclusions. Preliminary studies of peripheral blood in leukemia indicate that it may be helpful in differentiating certain abnormal cellular elements. The chemistry of acridine orange with respect to metachromatic color differentiation of DNA and RNA has been discussed. Based on supravital observations of the L. E. cell phenomenon, speculation has been offered as to the site of interaction of the L.E. factor with DNA. |
| doi_str_mv | 10.1182/blood.V17.5.643.643 |
| format | Article |
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The supravital method is of value in distinguishing nucleated cellular elements, reticulocytes and erythrocytic inclusions. Preliminary studies of peripheral blood in leukemia indicate that it may be helpful in differentiating certain abnormal cellular elements. The chemistry of acridine orange with respect to metachromatic color differentiation of DNA and RNA has been discussed. Based on supravital observations of the L. E. cell phenomenon, speculation has been offered as to the site of interaction of the L.E. factor with DNA.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V17.5.643.643</identifier><identifier>PMID: 13718493</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acridine Orange ; Acridines ; Blood ; Fluorescence ; Humans ; Old Medline</subject><ispartof>Blood, 1961-05, Vol.17 (5), p.643-649</ispartof><rights>1961 American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-27c735625150eb3a932a2b4fb514ad3e997425870ef38eadd60a5bd371b722603</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13718493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jackson, John F.</creatorcontrib><title>Supravital Blood Studies, Using Acridine Orange Fluorescence</title><title>Blood</title><addtitle>Blood</addtitle><description>A simple method for supravital fluorochroming of blood with acridine orange has been described. 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E. cell phenomenon, speculation has been offered as to the site of interaction of the L.E. factor with DNA.</description><subject>Acridine Orange</subject><subject>Acridines</subject><subject>Blood</subject><subject>Fluorescence</subject><subject>Humans</subject><subject>Old Medline</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1961</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9Lw0AQxRdRbK1-AkFy8mTi_s0moIdarAqFHmq9LpvspKykSd1NCn57N7bgzcMwl_fevPkhdE1wQkhG74u6bU3yQWQikpSzYU7QmAiaxRhTfIrGGOM05rkkI3Th_SfGhDMqztGIMEkynrMxelj1O6f3ttN19DQERquuNxb8XbT2ttlE09JZYxuIlk43G4jmdd868CU0JVyis0rXHq6Oe4LW8-f32Wu8WL68zaaLuORp2sVUlpKJlAoiMBRM54xqWvCqEIRrwyDPJacikxgqloE2JsVaFCZ0LCSlKWYTdHvI3bn2qwffqa0NDepaN9D2XmVUCsokD0J2EJau9d5BpXbObrX7VgSrAZr6haYCNCVUADZMcN0c4_tiC-bPc6QUBI8HAYQn9xac8qUdABjroOyUae2_B34AfFN9Ew</recordid><startdate>196105</startdate><enddate>196105</enddate><creator>Jackson, John F.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196105</creationdate><title>Supravital Blood Studies, Using Acridine Orange Fluorescence</title><author>Jackson, John F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-27c735625150eb3a932a2b4fb514ad3e997425870ef38eadd60a5bd371b722603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1961</creationdate><topic>Acridine Orange</topic><topic>Acridines</topic><topic>Blood</topic><topic>Fluorescence</topic><topic>Humans</topic><topic>Old Medline</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, John F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, John F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supravital Blood Studies, Using Acridine Orange Fluorescence</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1961-05</date><risdate>1961</risdate><volume>17</volume><issue>5</issue><spage>643</spage><epage>649</epage><pages>643-649</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>A simple method for supravital fluorochroming of blood with acridine orange has been described. 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| ispartof | Blood, 1961-05, Vol.17 (5), p.643-649 |
| issn | 0006-4971 1528-0020 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acridine Orange Acridines Blood Fluorescence Humans Old Medline |
| title | Supravital Blood Studies, Using Acridine Orange Fluorescence |
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