A Peanut Factor for Hæmostasis in Hæmophilia
IT is known that there are unpredictable apparent remissions of clinical symptoms enjoyed by hæmophiliacs; but these remissions have not been correlated with any influences such as time of year, food eaten, weather conditions, other diseases, or physical condition of the patient. The lack of ‘antihæ...
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| Veröffentlicht in: | Nature (London) 1960-02, Vol.185 (4711), p.469-470 |
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| creator | BOUDREAUX, H. BRUCE FRAMPTON, VERNON L |
| description | IT is known that there are unpredictable apparent remissions of clinical symptoms enjoyed by hæmophiliacs; but these remissions have not been correlated with any influences such as time of year, food eaten, weather conditions, other diseases, or physical condition of the patient. The lack of ‘antihæmophilic factor’ associated with classic hæmophilia has been attributed
1
to a hypothetical block during the metabolic synthesis of the factor resulting from the action of the mutant gene of hæmophilia, such as occurs in the nutritional mutants of
Neurospora
and in eye pigment development in certain mutants of
Drosophila
2
. In the cases of
Neurospora
, and
Drosophila
, and other organisms studied, the addition of the substances the synthesis of which is blocked genetically results in normal metabolism. If this is the case in hæmophilia, it may be possible to supply, by mouth or injection, the unavailable material necessary for normal production of the hæmostatic substance lacking in hæmophiliacs. However, the few instances of success of various supplements, such as vitamins E and B
12
, X-rays, and œstrogen, have not been confirmed
3–7
. |
| doi_str_mv | 10.1038/185469a0 |
| format | Article |
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1
to a hypothetical block during the metabolic synthesis of the factor resulting from the action of the mutant gene of hæmophilia, such as occurs in the nutritional mutants of
Neurospora
and in eye pigment development in certain mutants of
Drosophila
2
. In the cases of
Neurospora
, and
Drosophila
, and other organisms studied, the addition of the substances the synthesis of which is blocked genetically results in normal metabolism. If this is the case in hæmophilia, it may be possible to supply, by mouth or injection, the unavailable material necessary for normal production of the hæmostatic substance lacking in hæmophiliacs. However, the few instances of success of various supplements, such as vitamins E and B
12
, X-rays, and œstrogen, have not been confirmed
3–7
.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/185469a0</identifier><identifier>PMID: 18990814</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adolescent ; Alcohols - chemistry ; Arachis - chemistry ; Arachis - metabolism ; Coagulants - chemistry ; Coagulants - therapeutic use ; Hemophilia A - diet therapy ; Hemophilia A - therapy ; Hemostasis - physiology ; Humanities and Social Sciences ; Humans ; letter ; Middle Aged ; multidisciplinary ; Old Medline ; Plant Extracts - chemistry ; Plant Extracts - therapeutic use ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1960-02, Vol.185 (4711), p.469-470</ispartof><rights>Springer Nature Limited 1960</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-e13c1319031d0adc24b0183b0a1993676aecf8bb34d498e9b81a65af7cae01813</citedby><cites>FETCH-LOGICAL-c336t-e13c1319031d0adc24b0183b0a1993676aecf8bb34d498e9b81a65af7cae01813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/185469a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/185469a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18990814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOUDREAUX, H. BRUCE</creatorcontrib><creatorcontrib>FRAMPTON, VERNON L</creatorcontrib><title>A Peanut Factor for Hæmostasis in Hæmophilia</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>IT is known that there are unpredictable apparent remissions of clinical symptoms enjoyed by hæmophiliacs; but these remissions have not been correlated with any influences such as time of year, food eaten, weather conditions, other diseases, or physical condition of the patient. The lack of ‘antihæmophilic factor’ associated with classic hæmophilia has been attributed
1
to a hypothetical block during the metabolic synthesis of the factor resulting from the action of the mutant gene of hæmophilia, such as occurs in the nutritional mutants of
Neurospora
and in eye pigment development in certain mutants of
Drosophila
2
. In the cases of
Neurospora
, and
Drosophila
, and other organisms studied, the addition of the substances the synthesis of which is blocked genetically results in normal metabolism. If this is the case in hæmophilia, it may be possible to supply, by mouth or injection, the unavailable material necessary for normal production of the hæmostatic substance lacking in hæmophiliacs. However, the few instances of success of various supplements, such as vitamins E and B
12
, X-rays, and œstrogen, have not been confirmed
3–7
.</description><subject>Adolescent</subject><subject>Alcohols - chemistry</subject><subject>Arachis - chemistry</subject><subject>Arachis - metabolism</subject><subject>Coagulants - chemistry</subject><subject>Coagulants - therapeutic use</subject><subject>Hemophilia A - diet therapy</subject><subject>Hemophilia A - therapy</subject><subject>Hemostasis - physiology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - therapeutic use</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1960</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M9KxDAQBvAgiruugk8gPYkeus402TQ5LovrCgt60HOZpql26Z81aQ--kC_ii1lpRU8ewhDmxwfzMXaOMEfg6gbVQkhNcMCmKGIZCqniQzYFiFQIissJO_F-BwALjMUxm6DSGhSKKZsvg0dLddcGazJt44K8f5vPj6rxLfnCB0U9fPevRVnQKTvKqfT2bJwz9ry-fVptwu3D3f1quQ0N57INLXKDHDVwzIAyE4kUUPEUCLXmMpZkTa7SlItMaGV1qpDkgvLYkO0h8hm7HHL3rnnrrG-TqvDGliXVtul8oqJYKBGLHl4N0LjGe2fzZO-Kitx7gpB8d5P8dNPTizGzSyub_cKxjB5cD8D3q_rFumTXdK7u7_wnrKa2c_ZP2Ai-AH6bdP8</recordid><startdate>19600213</startdate><enddate>19600213</enddate><creator>BOUDREAUX, H. BRUCE</creator><creator>FRAMPTON, VERNON L</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19600213</creationdate><title>A Peanut Factor for Hæmostasis in Hæmophilia</title><author>BOUDREAUX, H. BRUCE ; FRAMPTON, VERNON L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-e13c1319031d0adc24b0183b0a1993676aecf8bb34d498e9b81a65af7cae01813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1960</creationdate><topic>Adolescent</topic><topic>Alcohols - chemistry</topic><topic>Arachis - chemistry</topic><topic>Arachis - metabolism</topic><topic>Coagulants - chemistry</topic><topic>Coagulants - therapeutic use</topic><topic>Hemophilia A - diet therapy</topic><topic>Hemophilia A - therapy</topic><topic>Hemostasis - physiology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - therapeutic use</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOUDREAUX, H. BRUCE</creatorcontrib><creatorcontrib>FRAMPTON, VERNON L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOUDREAUX, H. BRUCE</au><au>FRAMPTON, VERNON L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Peanut Factor for Hæmostasis in Hæmophilia</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1960-02-13</date><risdate>1960</risdate><volume>185</volume><issue>4711</issue><spage>469</spage><epage>470</epage><pages>469-470</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>IT is known that there are unpredictable apparent remissions of clinical symptoms enjoyed by hæmophiliacs; but these remissions have not been correlated with any influences such as time of year, food eaten, weather conditions, other diseases, or physical condition of the patient. The lack of ‘antihæmophilic factor’ associated with classic hæmophilia has been attributed
1
to a hypothetical block during the metabolic synthesis of the factor resulting from the action of the mutant gene of hæmophilia, such as occurs in the nutritional mutants of
Neurospora
and in eye pigment development in certain mutants of
Drosophila
2
. In the cases of
Neurospora
, and
Drosophila
, and other organisms studied, the addition of the substances the synthesis of which is blocked genetically results in normal metabolism. If this is the case in hæmophilia, it may be possible to supply, by mouth or injection, the unavailable material necessary for normal production of the hæmostatic substance lacking in hæmophiliacs. However, the few instances of success of various supplements, such as vitamins E and B
12
, X-rays, and œstrogen, have not been confirmed
3–7
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18990814</pmid><doi>10.1038/185469a0</doi><tpages>2</tpages></addata></record> |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Alcohols - chemistry Arachis - chemistry Arachis - metabolism Coagulants - chemistry Coagulants - therapeutic use Hemophilia A - diet therapy Hemophilia A - therapy Hemostasis - physiology Humanities and Social Sciences Humans letter Middle Aged multidisciplinary Old Medline Plant Extracts - chemistry Plant Extracts - therapeutic use Science Science (multidisciplinary) |
| title | A Peanut Factor for Hæmostasis in Hæmophilia |
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