An electron microscopic study of liver in hepatomegaly presumably caused by amebiasis
Liver biopsis from six patients with hepatomegaly presumably due to amebiasis, and one healthy subject were studied by light and electron microscopy. Electron microscopic observations suggested parenchymal damage. Mitochondria and the endoplasmic reticulum were the principal targets of injury. Parac...
Gespeichert in:
| Veröffentlicht in: | Experimental and molecular pathology 1975-02, Vol.22 (1), p.118-132 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 132 |
|---|---|
| container_issue | 1 |
| container_start_page | 118 |
| container_title | Experimental and molecular pathology |
| container_volume | 22 |
| creator | Tandon, B.N. Tandon, H.D. Puri, B.K. |
| description | Liver biopsis from six patients with hepatomegaly presumably due to amebiasis, and one healthy subject were studied by light and electron microscopy. Electron microscopic observations suggested parenchymal damage. Mitochondria and the endoplasmic reticulum were the principal targets of injury. Paracrystalline, filamentous, and tubular inclusions were observed in the matrices of large and bizzarre shaped mitochondria in five of the six patients. The endoplasmic reticulum was dilated and hypertrophied in all cases. No amebae or virus associated with amebae were observed. Light microscopic changes were mild and nonspecific. These findings suggest that the hepatomegaly is likely to be due to active regeneration of the liver cells following parenchymal injury of a nonspecific nature. |
| doi_str_mv | 10.1016/0014-4800(75)90057-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_82732343</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>001448007590057X</els_id><sourcerecordid>82732343</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-82e3b6b52c6ae99472dfb62771c0bbdbe391aac24e967bff30d06359c93171573</originalsourceid><addsrcrecordid>eNp9kMtKxDAUhoN4G0ffwEVWoovqSdMkk40g4g0G3Ci4C0l6qpHeTFph3t6OI7pzdQ78F_g_Qo4ZnDNg8gKAFVmxADhV4kwDCJW9bJEZAy0z0IXYJrNfyz45SOkdADSwfI_sMsmVUDPyfNVSrNEPsWtpE3zsku_64GkaxnJFu4rW4RMjDS19w94OXYOvtl7RPmIaG-um19sxYUnditoGXbAppEOyU9k64dHPnZPn25un6_ts-Xj3cH21zDwXcsgWOXInnci9tKh1ofKycjJXinlwrnTINbPW5wVqqVxVcShBcqG95kwxoficnGx6-9h9jJgG04Tksa5ti92YzCJXPOcFn4zFxrgemCJWpo-hsXFlGJg1TLMmZdakjBLmG6Z5mWLHP_2ja7D8C33Tm-TLjYzTxs-A0SQfsPVYhjghNWUX_u__AiHXhEE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>82732343</pqid></control><display><type>article</type><title>An electron microscopic study of liver in hepatomegaly presumably caused by amebiasis</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Tandon, B.N. ; Tandon, H.D. ; Puri, B.K.</creator><creatorcontrib>Tandon, B.N. ; Tandon, H.D. ; Puri, B.K.</creatorcontrib><description>Liver biopsis from six patients with hepatomegaly presumably due to amebiasis, and one healthy subject were studied by light and electron microscopy. Electron microscopic observations suggested parenchymal damage. Mitochondria and the endoplasmic reticulum were the principal targets of injury. Paracrystalline, filamentous, and tubular inclusions were observed in the matrices of large and bizzarre shaped mitochondria in five of the six patients. The endoplasmic reticulum was dilated and hypertrophied in all cases. No amebae or virus associated with amebae were observed. Light microscopic changes were mild and nonspecific. These findings suggest that the hepatomegaly is likely to be due to active regeneration of the liver cells following parenchymal injury of a nonspecific nature.</description><identifier>ISSN: 0014-4800</identifier><identifier>EISSN: 1096-0945</identifier><identifier>DOI: 10.1016/0014-4800(75)90057-X</identifier><identifier>PMID: 163757</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Biopsy ; Crystallography ; Endoplasmic Reticulum - ultrastructure ; Feces - analysis ; Female ; Hemagglutination Tests ; Humans ; Inclusion Bodies - ultrastructure ; Kupffer Cells - ultrastructure ; Liver - ultrastructure ; Liver Abscess, Amebic - pathology ; Liver Function Tests ; Liver Glycogen ; Male ; Microscopy, Electron ; Middle Aged ; Mitochondria, Liver - ultrastructure</subject><ispartof>Experimental and molecular pathology, 1975-02, Vol.22 (1), p.118-132</ispartof><rights>1975</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-82e3b6b52c6ae99472dfb62771c0bbdbe391aac24e967bff30d06359c93171573</citedby><cites>FETCH-LOGICAL-c356t-82e3b6b52c6ae99472dfb62771c0bbdbe391aac24e967bff30d06359c93171573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-4800(75)90057-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/163757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tandon, B.N.</creatorcontrib><creatorcontrib>Tandon, H.D.</creatorcontrib><creatorcontrib>Puri, B.K.</creatorcontrib><title>An electron microscopic study of liver in hepatomegaly presumably caused by amebiasis</title><title>Experimental and molecular pathology</title><addtitle>Exp Mol Pathol</addtitle><description>Liver biopsis from six patients with hepatomegaly presumably due to amebiasis, and one healthy subject were studied by light and electron microscopy. Electron microscopic observations suggested parenchymal damage. Mitochondria and the endoplasmic reticulum were the principal targets of injury. Paracrystalline, filamentous, and tubular inclusions were observed in the matrices of large and bizzarre shaped mitochondria in five of the six patients. The endoplasmic reticulum was dilated and hypertrophied in all cases. No amebae or virus associated with amebae were observed. Light microscopic changes were mild and nonspecific. These findings suggest that the hepatomegaly is likely to be due to active regeneration of the liver cells following parenchymal injury of a nonspecific nature.</description><subject>Adult</subject><subject>Biopsy</subject><subject>Crystallography</subject><subject>Endoplasmic Reticulum - ultrastructure</subject><subject>Feces - analysis</subject><subject>Female</subject><subject>Hemagglutination Tests</subject><subject>Humans</subject><subject>Inclusion Bodies - ultrastructure</subject><subject>Kupffer Cells - ultrastructure</subject><subject>Liver - ultrastructure</subject><subject>Liver Abscess, Amebic - pathology</subject><subject>Liver Function Tests</subject><subject>Liver Glycogen</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Mitochondria, Liver - ultrastructure</subject><issn>0014-4800</issn><issn>1096-0945</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoN4G0ffwEVWoovqSdMkk40g4g0G3Ci4C0l6qpHeTFph3t6OI7pzdQ78F_g_Qo4ZnDNg8gKAFVmxADhV4kwDCJW9bJEZAy0z0IXYJrNfyz45SOkdADSwfI_sMsmVUDPyfNVSrNEPsWtpE3zsku_64GkaxnJFu4rW4RMjDS19w94OXYOvtl7RPmIaG-um19sxYUnditoGXbAppEOyU9k64dHPnZPn25un6_ts-Xj3cH21zDwXcsgWOXInnci9tKh1ofKycjJXinlwrnTINbPW5wVqqVxVcShBcqG95kwxoficnGx6-9h9jJgG04Tksa5ti92YzCJXPOcFn4zFxrgemCJWpo-hsXFlGJg1TLMmZdakjBLmG6Z5mWLHP_2ja7D8C33Tm-TLjYzTxs-A0SQfsPVYhjghNWUX_u__AiHXhEE</recordid><startdate>197502</startdate><enddate>197502</enddate><creator>Tandon, B.N.</creator><creator>Tandon, H.D.</creator><creator>Puri, B.K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197502</creationdate><title>An electron microscopic study of liver in hepatomegaly presumably caused by amebiasis</title><author>Tandon, B.N. ; Tandon, H.D. ; Puri, B.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-82e3b6b52c6ae99472dfb62771c0bbdbe391aac24e967bff30d06359c93171573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adult</topic><topic>Biopsy</topic><topic>Crystallography</topic><topic>Endoplasmic Reticulum - ultrastructure</topic><topic>Feces - analysis</topic><topic>Female</topic><topic>Hemagglutination Tests</topic><topic>Humans</topic><topic>Inclusion Bodies - ultrastructure</topic><topic>Kupffer Cells - ultrastructure</topic><topic>Liver - ultrastructure</topic><topic>Liver Abscess, Amebic - pathology</topic><topic>Liver Function Tests</topic><topic>Liver Glycogen</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Mitochondria, Liver - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tandon, B.N.</creatorcontrib><creatorcontrib>Tandon, H.D.</creatorcontrib><creatorcontrib>Puri, B.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and molecular pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tandon, B.N.</au><au>Tandon, H.D.</au><au>Puri, B.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An electron microscopic study of liver in hepatomegaly presumably caused by amebiasis</atitle><jtitle>Experimental and molecular pathology</jtitle><addtitle>Exp Mol Pathol</addtitle><date>1975-02</date><risdate>1975</risdate><volume>22</volume><issue>1</issue><spage>118</spage><epage>132</epage><pages>118-132</pages><issn>0014-4800</issn><eissn>1096-0945</eissn><abstract>Liver biopsis from six patients with hepatomegaly presumably due to amebiasis, and one healthy subject were studied by light and electron microscopy. Electron microscopic observations suggested parenchymal damage. Mitochondria and the endoplasmic reticulum were the principal targets of injury. Paracrystalline, filamentous, and tubular inclusions were observed in the matrices of large and bizzarre shaped mitochondria in five of the six patients. The endoplasmic reticulum was dilated and hypertrophied in all cases. No amebae or virus associated with amebae were observed. Light microscopic changes were mild and nonspecific. These findings suggest that the hepatomegaly is likely to be due to active regeneration of the liver cells following parenchymal injury of a nonspecific nature.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>163757</pmid><doi>10.1016/0014-4800(75)90057-X</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4800 |
| ispartof | Experimental and molecular pathology, 1975-02, Vol.22 (1), p.118-132 |
| issn | 0014-4800 1096-0945 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82732343 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Biopsy Crystallography Endoplasmic Reticulum - ultrastructure Feces - analysis Female Hemagglutination Tests Humans Inclusion Bodies - ultrastructure Kupffer Cells - ultrastructure Liver - ultrastructure Liver Abscess, Amebic - pathology Liver Function Tests Liver Glycogen Male Microscopy, Electron Middle Aged Mitochondria, Liver - ultrastructure |
| title | An electron microscopic study of liver in hepatomegaly presumably caused by amebiasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T20%3A37%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20electron%20microscopic%20study%20of%20liver%20in%20hepatomegaly%20presumably%20caused%20by%20amebiasis&rft.jtitle=Experimental%20and%20molecular%20pathology&rft.au=Tandon,%20B.N.&rft.date=1975-02&rft.volume=22&rft.issue=1&rft.spage=118&rft.epage=132&rft.pages=118-132&rft.issn=0014-4800&rft.eissn=1096-0945&rft_id=info:doi/10.1016/0014-4800(75)90057-X&rft_dat=%3Cproquest_cross%3E82732343%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=82732343&rft_id=info:pmid/163757&rft_els_id=001448007590057X&rfr_iscdi=true |