Effects of Δ 9-tetrahydrocannabinol on the levels of cyclic adenosine 3',5'-monophosphate in mouse brain
The effects of intraperitoneal injections of various doses of Δ 9-tetrahydrocannabinol ( Δ 9-THC) on brain levels of cyclic adenosine 3',5'-monophosphate (cyclic AMP) have been studied in mice. Doses of Δ 9-THC in the range of 0.1 to 1.0 mg/kg cause a 50–160 per cent elevation of cyclic AM...
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| Veröffentlicht in: | Biochemical pharmacology 1974-07, Vol.23 (13), p.1817-1825 |
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| container_title | Biochemical pharmacology |
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| creator | Dolby, Thomas W. Kleinsmith, Lewis J. |
| description | The effects of intraperitoneal injections of various doses of
Δ
9-tetrahydrocannabinol (
Δ
9-THC) on brain levels of cyclic adenosine 3',5'-monophosphate (cyclic AMP) have been studied in mice. Doses of
Δ
9-THC in the range of 0.1 to 1.0 mg/kg cause a 50–160 per cent elevation of cyclic AMP levels compared to controls (P < 0.0005), while doses of
Δ
9-THC in the range of 2.0 to 10.0 mg/kg cause a 30–60 per cent depression of cyclic AMP levels (P = 0.025
to 0.0005). This pattern was obtained in whole brain, as well as in dissected samples of cortex, cerebellum and medulla. This over-all biphasic effect of THC on cyclic AMP levels correlates with known changes in biogenic amines, temperature regulation, and behavior caused by this drug. |
| doi_str_mv | 10.1016/0006-2952(74)90190-7 |
| format | Article |
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Δ
9-tetrahydrocannabinol (
Δ
9-THC) on brain levels of cyclic adenosine 3',5'-monophosphate (cyclic AMP) have been studied in mice. Doses of
Δ
9-THC in the range of 0.1 to 1.0 mg/kg cause a 50–160 per cent elevation of cyclic AMP levels compared to controls (P < 0.0005), while doses of
Δ
9-THC in the range of 2.0 to 10.0 mg/kg cause a 30–60 per cent depression of cyclic AMP levels (P = 0.025
to 0.0005). This pattern was obtained in whole brain, as well as in dissected samples of cortex, cerebellum and medulla. This over-all biphasic effect of THC on cyclic AMP levels correlates with known changes in biogenic amines, temperature regulation, and behavior caused by this drug.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(74)90190-7</identifier><identifier>PMID: 4376400</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adenylyl Cyclases - metabolism ; Animals ; Brain - drug effects ; Brain - metabolism ; Cannabis - pharmacology ; Cattle ; Cerebellum - enzymology ; Cerebral Cortex - metabolism ; Cyclic AMP - metabolism ; Dose-Response Relationship, Drug ; Dronabinol - pharmacology ; Hypothalamus - enzymology ; Medulla Oblongata - enzymology ; Mice ; Microwaves ; Muscles - enzymology ; Organ Specificity ; Phosphoric Diester Hydrolases - metabolism ; Postmortem Changes ; Protein Kinases - metabolism</subject><ispartof>Biochemical pharmacology, 1974-07, Vol.23 (13), p.1817-1825</ispartof><rights>1974</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(74)90190-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4376400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dolby, Thomas W.</creatorcontrib><creatorcontrib>Kleinsmith, Lewis J.</creatorcontrib><title>Effects of Δ 9-tetrahydrocannabinol on the levels of cyclic adenosine 3',5'-monophosphate in mouse brain</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>The effects of intraperitoneal injections of various doses of
Δ
9-tetrahydrocannabinol (
Δ
9-THC) on brain levels of cyclic adenosine 3',5'-monophosphate (cyclic AMP) have been studied in mice. Doses of
Δ
9-THC in the range of 0.1 to 1.0 mg/kg cause a 50–160 per cent elevation of cyclic AMP levels compared to controls (P < 0.0005), while doses of
Δ
9-THC in the range of 2.0 to 10.0 mg/kg cause a 30–60 per cent depression of cyclic AMP levels (P = 0.025
to 0.0005). This pattern was obtained in whole brain, as well as in dissected samples of cortex, cerebellum and medulla. This over-all biphasic effect of THC on cyclic AMP levels correlates with known changes in biogenic amines, temperature regulation, and behavior caused by this drug.</description><subject>Adenylyl Cyclases - metabolism</subject><subject>Animals</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cannabis - pharmacology</subject><subject>Cattle</subject><subject>Cerebellum - enzymology</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cyclic AMP - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Dronabinol - pharmacology</subject><subject>Hypothalamus - enzymology</subject><subject>Medulla Oblongata - enzymology</subject><subject>Mice</subject><subject>Microwaves</subject><subject>Muscles - enzymology</subject><subject>Organ Specificity</subject><subject>Phosphoric Diester Hydrolases - metabolism</subject><subject>Postmortem Changes</subject><subject>Protein Kinases - metabolism</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kdtKxDAQhoMouq6-gUKuPIDVHNokvRFkWQ-w4I1ehzSdspE2WZvuwr6Hz-Uzmeri1TDzfwz__IPQGSW3lFBxRwgRGSsLdiXz65LQkmRyD02okjyNhdpHk3_kCB3H-DG2StBDdJhzKXJCJsjNmwbsEHFo8PcXLrMBht4st3UfrPHeVM6HFgePhyXgFjbQ_qJ2a1tnsanBh-g8YH55U1xmXfBhtQxxtTQDYOdxF9YRcNUb50_QQWPaCKe7OkXvj_O32XO2eH16mT0sMqBEkYxBIwUTtlIVlw0Qmdra1JQXokjeRUVUznLGgbKK5iIhZcEVBzBC1NAIPkUXf3tXffhcQxx056KFtjUekhutmOSUCZXA8x24rjqo9ap3nem3epdN0u__9HQzbBz0OloH3kLt-hSZroPTlOjxF3pMVo9Ba5nr319oyX8ArgR6YQ</recordid><startdate>19740701</startdate><enddate>19740701</enddate><creator>Dolby, Thomas W.</creator><creator>Kleinsmith, Lewis J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19740701</creationdate><title>Effects of Δ 9-tetrahydrocannabinol on the levels of cyclic adenosine 3',5'-monophosphate in mouse brain</title><author>Dolby, Thomas W. ; Kleinsmith, Lewis J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1080-2ef7626cb8b37fe07f76dad135658616b0842423e12b1467fe95383eea66def63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Adenylyl Cyclases - metabolism</topic><topic>Animals</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Cannabis - pharmacology</topic><topic>Cattle</topic><topic>Cerebellum - enzymology</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cyclic AMP - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Dronabinol - pharmacology</topic><topic>Hypothalamus - enzymology</topic><topic>Medulla Oblongata - enzymology</topic><topic>Mice</topic><topic>Microwaves</topic><topic>Muscles - enzymology</topic><topic>Organ Specificity</topic><topic>Phosphoric Diester Hydrolases - metabolism</topic><topic>Postmortem Changes</topic><topic>Protein Kinases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dolby, Thomas W.</creatorcontrib><creatorcontrib>Kleinsmith, Lewis J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dolby, Thomas W.</au><au>Kleinsmith, Lewis J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Δ 9-tetrahydrocannabinol on the levels of cyclic adenosine 3',5'-monophosphate in mouse brain</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1974-07-01</date><risdate>1974</risdate><volume>23</volume><issue>13</issue><spage>1817</spage><epage>1825</epage><pages>1817-1825</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>The effects of intraperitoneal injections of various doses of
Δ
9-tetrahydrocannabinol (
Δ
9-THC) on brain levels of cyclic adenosine 3',5'-monophosphate (cyclic AMP) have been studied in mice. Doses of
Δ
9-THC in the range of 0.1 to 1.0 mg/kg cause a 50–160 per cent elevation of cyclic AMP levels compared to controls (P < 0.0005), while doses of
Δ
9-THC in the range of 2.0 to 10.0 mg/kg cause a 30–60 per cent depression of cyclic AMP levels (P = 0.025
to 0.0005). This pattern was obtained in whole brain, as well as in dissected samples of cortex, cerebellum and medulla. This over-all biphasic effect of THC on cyclic AMP levels correlates with known changes in biogenic amines, temperature regulation, and behavior caused by this drug.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>4376400</pmid><doi>10.1016/0006-2952(74)90190-7</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2952 |
| ispartof | Biochemical pharmacology, 1974-07, Vol.23 (13), p.1817-1825 |
| issn | 0006-2952 1873-2968 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82731268 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenylyl Cyclases - metabolism Animals Brain - drug effects Brain - metabolism Cannabis - pharmacology Cattle Cerebellum - enzymology Cerebral Cortex - metabolism Cyclic AMP - metabolism Dose-Response Relationship, Drug Dronabinol - pharmacology Hypothalamus - enzymology Medulla Oblongata - enzymology Mice Microwaves Muscles - enzymology Organ Specificity Phosphoric Diester Hydrolases - metabolism Postmortem Changes Protein Kinases - metabolism |
| title | Effects of Δ 9-tetrahydrocannabinol on the levels of cyclic adenosine 3',5'-monophosphate in mouse brain |
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