Glomerular immune complex deposits associated with mouse mammary tumor

Adult Paris R-III mice with localized mamary tumors were found to have subendothelial glomerular immune complex deposits by electron microscopy and immunofluorescence. In addition to IgG adn B-1-C, the glomeruli contained antigenic material that reacted with an antiserum to mouse mamary tumor virus....

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1975-02, Vol.35 (2), p.302-304
Hauptverfasser:	Pascal, R R, Rollwagen, F M, Harding, T A, Schiavone, W A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Antibody Complex - analysis Antigen-Antibody Reactions Antigens, Neoplasm - analysis Antigens, Viral - analysis Female Fluorescent Antibody Technique Goats - immunology Immunoglobulin G - analysis Kidney Glomerulus - immunology Mammary Neoplasms, Experimental - immunology Mammary Tumor Virus, Mouse - immunology Mice Microscopy, Electron Rabbits - immunology
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Zusammenfassung:	Adult Paris R-III mice with localized mamary tumors were found to have subendothelial glomerular immune complex deposits by electron microscopy and immunofluorescence. In addition to IgG adn B-1-C, the glomeruli contained antigenic material that reacted with an antiserum to mouse mamary tumor virus. These findings support the hypothesis that many animals with congenitally or neonatally induced virus-related tumors are not immunologically tolerant to the oncogenic virus.
ISSN:	0008-5472