Effects of Lipoid A Component of Escherichia coli Endotoxin on Dermal Reactivity of Rabbits to Epinephrine.

Effects of Lipoid A Component of Escherichia coli Endotoxin on Dermal Reactivity of Rabbits to Epinephrine.

Summary The purified and polysaccharide-free lipoid A component of E. coli 0111: B4 endotoxin, upon intravenous injection into rabbits, strikingly alters dermal reactivity to epinephrine. Grossly, the lesions thus produced are red or brownish in appearance or show marked hemorrhages. Lipoid A is act...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1960-04, Vol.103 (4), p.783-786
Hauptverfasser: Neter, Erwin, Anzai, Hiroshi, Gorzynski, Eugene A., Nowotny, Alois, Westphal, Otto
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antitoxins
Endotoxins
Epinephrine
Escherichia coli
Lagomorpha
Lipopolysaccharides - pharmacology
Old Medline
Rabbits
Toxins, Biological
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Zusammenfassung:Summary The purified and polysaccharide-free lipoid A component of E. coli 0111: B4 endotoxin, upon intravenous injection into rabbits, strikingly alters dermal reactivity to epinephrine. Grossly, the lesions thus produced are red or brownish in appearance or show marked hemorrhages. Lipoid A is active in amounts as small as 2 μg kg. The original lipopolysaccharide is approximately 10 times more potent than the lipoid A fraction obtained therefrom. Phenoxybenzamine hydrochloride inhibits the epinephrine reaction in rabbits injected with lipoid A.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-103-25669